Delayed treatment of endocrine mucin–producing sweat gland carcinoma initially diagnosed as a chalazion

Meltzer, Orr A.; Joseph, Jeffrey M.

doi:10.1016/j.jdcr.2019.06.031

Cited by 5 publications

(6 citation statements)

References 4 publications

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“…1,9,14 Since EMPSGC can mimic non-neoplastic or inflammatory lesions such as chalazion, it may be treated conservatively, resulting in delayed treatment. 60 Hasegawa et al suggested large red/blue globules in pink ovoid nests seen in their case could be a characteristic dermoscopic finding specific to EMPSGC. 23 Recently, Nakamura et al also noted this finding in one of their four unusual EMPSGC cases in Japanese males, all of which were located on the cheek.…”

Section: Demographics Clinical Presentation and Dermoscopic Findingsmentioning

confidence: 72%

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Endocrine mucin‐producing sweat gland carcinoma and associated primary cutaneous mucinous carcinoma: Review of the literature

Bundele

2021

J Cutan Pathol

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Background Endocrine mucin‐producing sweat gland carcinoma (EMPSGC) is a rare, low‐grade, cutaneous adnexal carcinoma with neuroendocrine differentiation. It is considered to be a precursor of invasive neuroendocrine type primary cutaneous mucinous carcinoma (PCMC). Objective To review clinicopathological literature summary of EMPSGC and associated neuroendocrine PCMC from all reported cases and compare its behavior vs non‐neuroendocrine PCMC data reported in the literature. Methods A review of English literature of all EMPSGC cases with and without associated PCMC was carried out. Results EMPSGC was associated with invasive neuroendocrine type PCMC in 35.7% of cases. We found the recurrence rate of PCMC associated with EMPSGC of about 12.3%, which is much less than the 30% recurrence rate reported for the non‐neuroendocrine subtype of PCMC. The non‐neuroendocrine subtype of PCMC shows a 4% and 11% rate of distant and lymph node metastasis, respectively, vs EMPSGC‐associated neuroendocrine type of PCMC, which is very indolent and only one recent case of locoregional metastasis out of 190 EMPSGC cases has been reported so far. Limitation Limitation of our study includes data derivation from case reports and case series in the literature. Conclusion The prognostic benefits for this cohort of patients may be considered in their overall management.

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Section: Demographics Clinical Presentation and Dermoscopic Findingsmentioning

confidence: 72%

“…Malignant neoplasms commonly considered include mucinous carcinoma, apocrine carcinoma, or basal cell carcinoma 1,9,14 . Since EMPSGC can mimic non‐neoplastic or inflammatory lesions such as chalazion, it may be treated conservatively, resulting in de‐layed treatment 60 …”

Section: Discussion With Review Of the Literaturementioning

confidence: 99%

Endocrine mucin‐producing sweat gland carcinoma and associated primary cutaneous mucinous carcinoma: Review of the literature

Bundele

2021

J Cutan Pathol

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“…The nuclei have fine granular or stippled chromatin imparting a “salt-and-pepper” appearance, and their cytoplasm is large and eosinophilic. In addition, it is important to emphasize the possibility of secreting mucins, both intracellularly and into the extracellular environment, a characteristic that, over time, has suggested a possible placement of EMPSGC in a spectrum of neoplasms that, at the extreme, would have primitive cutaneous mucinous carcinoma (PCMC) [ 1 , 3 , 4 , 5 , 6 , 8 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Endocrine Mucin-Producing Sweat Gland Carcinoma: Case Presentation with a Comprehensive Review of the Literature

Cazzato,

Bellitti,

Trilli

et al. 2023

Dermatopathology

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(1) Background: Endocrine Mucin-Producing Sweat Gland Carcinoma (EMPSGC) is a rare, low-grade, neuroendocrine-differentiated, cutaneous adnexal tumor, officially recognized by the World Health Organization (WHO) Skin Tumors Classification in 2018 as a separate entity and homologue of endocrine ductal carcinoma in situ (eDCIS)/solid papillary carcinoma of the breast. Although it is more frequent in the female sex, between 60 and 70 years old, in the peri-orbital region, EMPSGC has also been described in the male sex, in subjects under 60 and over 80, and in extra-eyelid localizations (cheek, temple, scalp), but also in extra-facial localizations (chest and scrotum). (2) Methods: We present the clinical case of a 71-year-old woman with an undated lesion of the scalp, which presented as a nodule, skin-colored, and 2.5 cm in maximum diameter. We also conduct a comprehensive literature review from 1997 to the end of 2022, consulting PubMed, Scopus, Web of Science (WoS), and Google Scholar using the following keywords: “Endocrine mucin-producing sweat gland carcinoma” and/or “EMPSGC” and/or “skin” and “cutaneous neoplasms”. In addition, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A total of 253 patients were recorded; 146 were females (57.7%) and 107 were males (42.2%). The vast majority of the lesions were in the eyelids (peri-ocular region), and only a minority of cases involved the cheeks, supra-auricular, retro-auricular, and occipital region, with very rare cases in the scalp, to which the present is also added. (4) Conclusions: The morphological and immunophenotypical features are essential both for the correct diagnosis and to be able to classify this lesion among the corresponding eDCIS/solid papillary carcinoma of the breast, with neuroendocrine differentiation. Recent papers have attempted to shed light on the molecular features of EMPSGC, and much remains to be conducted in the attempt to subtype the molecular profiles of these entities. Future studies with large case series, and especially with molecular biology techniques, will be needed to further add information about EMPSGC and its relationship in the PCMC spectrum.

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“…EMPSGC is a cutaneous adnexal tumor, often presenting as an asymptomatic, slow-growing nodule or papule with a predilection for the eyelids in females. 1 Two literature reviews published in February of 2013 and June 2021 documented a total of 20 cases and 190 cases, respectively, demonstrating an approximately 850% increase in the 8-year span. 2 , 3 Three metastatic cases have been reported, all occurring at least 7 years from initial diagnosis.…”

mentioning

confidence: 99%

“…To the Editor: We read with interest the successful experience of Meltzer et al 1 on the treatment of endocrine mucin-producing sweat gland carcinoma (EMPSGC) with Mohs micrographic surgery. The case emphasized the importance of timely diagnosis, as the rate of metastasis for EMPSGC is often higher compared to other non-melanoma skin cancers.…”

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confidence: 99%

Endocrine mucin-producing sweat gland carcinoma with regional metastases in an African American female

Mattia¹,

Thompson²,

Green³

et al. 2023

JAAD Case Reports

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Delayed treatment of endocrine mucin–producing sweat gland carcinoma initially diagnosed as a chalazion

Cited by 5 publications

References 4 publications

Endocrine mucin‐producing sweat gland carcinoma and associated primary cutaneous mucinous carcinoma: Review of the literature

Endocrine mucin‐producing sweat gland carcinoma and associated primary cutaneous mucinous carcinoma: Review of the literature

Endocrine Mucin-Producing Sweat Gland Carcinoma: Case Presentation with a Comprehensive Review of the Literature

Endocrine mucin-producing sweat gland carcinoma with regional metastases in an African American female

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