Endocrine-metabolic relations in rats with inherited stress-induced arterial hypertension

Shorin, Yu. P.; Al, Markel'; Selyatitskaya, V. G.; Palchikova, N. A.; Grinberg, Patrícia; Amstislavskii, S. Ya.

doi:10.1007/bf00841441

Cited by 8 publications

(6 citation statements)

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“…)) show that elevated plasma concentrations of BCAA amino acids positively correlate with the risk of developing cardiovascular diseases (stroke, myocardial infarction, coronary disease). In ISIAH rats, a decrease in the level of immunoreactive insulin in the blood and glucose tolerance has been previously found, probably due to a genetically determined increased activity of the sympathoadrenal and thyroid systems (Shorin et al, 1990;Buzueva et al, 2006). Activation of the pancreas sympathetic innervation reduces insulin production by β-cells, acting through α 2 -adrenergic receptors (van Duk et al, 1995), and thyroid hormones af-Metabolic profile of blood serum in experimental arterial hypertension fect insulin production through the regulation of insulin-like growth factor 1 secretion (Cavaliere et al, 1987).…”

Section: всаа Branched-chain Amino Acidsmentioning

confidence: 82%

Metabolic profile of blood serum in experimental arterial hypertension

Seryapina,

Malyavko,

Polityko

et al. 2023

Vestn. VOGiS

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The etiology of essential hypertension is intricate, since it employs simultaneously various body systems related to the regulation of blood pressure in one way or another: the sympathetic nervous system, renin-angiotensin-aldosterone and hypothalamic-pituitary-adrenal systems, renal and endothelial mechanisms. The pathogenesis of hypertension is influenced by a variety of both genetic and environmental factors, which determines the heterogeneity of the disease in human population. Hence, there is a need to perform research on experimental models – inbred animal strains, one of them being ISIAH rat strain, which is designed to simulate inherited stress-induced arterial hypertension as close as possible to primary (or essential) hypertension in humans. To determine specific markers of diseases, various omics technologies are applied, including metabolomics, which makes it possible to evaluate the content of low-molecular compounds – amino acids, lipids, carbohydrates, nucleic acids fragments – in biological samples available for clinical analysis (blood and urine). We analyzed the metabolic profile of the blood serum of male ISIAH rats with a genetic stress-dependent form of arterial hypertension in comparison with the normotensive WAG rats. Using the method of nuclear magnetic resonance spectroscopy (NMR spectroscopy), 56 metabolites in blood serum samples were identified, 18 of which were shown to have significant interstrain differences in serum concentrations. Statistical analysis of the data obtained showed that the hypertensive status of ISIAH rats is characterized by increased concentrations of leucine, isoleucine, valine, myo-inositol, isobutyrate, glutamate, glutamine, ornithine and creatine phosphate, and reduced concentrations of 2-hydroxyisobutyrate, betaine, tyrosine and tryptophan. Such a ratio of the metabolite concentrations is associated with changes in the regulation of glucose metabolism (metabolic markers – leucine, isoleucine, valine, myoinositol), of nitric oxide synthesis (ornithine) and catecholamine pathway (tyrosine), and with inflammatory processes (metabolic markers – betaine, tryptophan), all of these changes being typical for hypertensive status. Thus, metabolic profiling of the stress-dependent form of arterial hypertension seems to be an important result for a personalized approach to the prevention and treatment of hypertensive disease.

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Section: всаа Branched-chain Amino Acidsmentioning

confidence: 82%

Metabolic profile of blood serum in experimental arterial hypertension

Seryapina,

Malyavko,

Polityko

et al. 2023

Vestn. VOGiS

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“…Previously, we detected a lowered glucose tolerance in hypertensive rats [5]. In NISAG rats, depressed insulin levels may be linked with the elevated sympathetic tone, which may in turn be responsible for inhibition of insulin secretion via the a-adrenoceptors.…”

Section: Resultsmentioning

confidence: 84%

Endocrine functions in hypertensive rats of the NISAG strain exposed to epinephrine

et al. 1996

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Endocrine functions were investigated in normotensive (Wistar) and hypertensive (NIS-AG) rats before and on days 3, 7, and 21 after subcutaneous epinephrine administration. Rats of the NISAG strain are characterized by elevated plasma levels of aldosterone and thyroxine and lowered plasma levels of immunoreactive insulin, and their endocrine system develops a much stronger response to a single epinephrine injection than does that of Wistar rats. This is manifested in a still higher aldosterone level, elevated corticosterone and insulin concentrations, and reduced thyroxine content in the plasma.

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“…Moreover, expression of tyrosine hydroxylase gene (key enzyme of catecholamine biosynthesis) increases in the adrenal gland of NISAG rats [4]. These animals are also characterized by high activity of phenylethanolamine N-methyltransferase [5].…”

Section: Resultsmentioning

confidence: 99%

“…Signs of hyperplasia of the adrenal medulla were most pronounced in adult hypertensive animals with persistent arterial hypertension, as well as during the period of late ontogeny.The development of arterial hypertension in NISAG rats with hereditary stress-induced arterial hypertension [3] is related to hyperactivity of the sympathoadrenal and pituitary-adrenocortical systems playing a role in the stress response [4,5]. Previous studies showed that these animals are characterized by adrenocortical hyperplasia [1,2].…”

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confidence: 99%