Endocrine functions in hypertensive rats of the NISAG strain exposed to epinephrine

Abstract

Endocrine functions were investigated in normotensive (Wistar) and hypertensive (NIS-AG) rats before and on days 3, 7, and 21 after subcutaneous epinephrine administration. Rats of the NISAG strain are characterized by elevated plasma levels of aldosterone and thyroxine and lowered plasma levels of immunoreactive insulin, and their endocrine system develops a much stronger response to a single epinephrine injection than does that of Wistar rats. This is manifested in a still higher aldosterone level, elevated corticosterone and insulin concentrations, and reduced thyroxine content in the plasma.

Functional activity of the sympathoadrenal system in hypertensive NISAG rats

“…This specific feature can be associated with increased sensitivity of effector systems to vasoconstrictor influences, which was previously demonstrated in in vitro experiments [1]. Other neurohormonal mechanisms cannot be excluded (e.g., increase in thyroid activity [6], adrenocortical hyperfunction, and potentiation of vasoconstriction by glucocorticoid hormones). The increase in basal blood pressure can result from morphological changes in the target organs of NISAG rats [2,4,5].…”

Neuroendocrine profiling in inherited stress-induced arterial hypertension rat strain with stress-sensitive arterial hypertension

“…When comparisons were based on measurements of plasma corticosterone content, the response of the ISIAH rats to such stressors as restraint, heat stress, epinephrine injection was enhanced relative to normotensive rats (Jacobson et al 1996, Petrova et al 1997, Antonov et al 2000. The ISIAH hypertensives were found to differ from the Wistar albino Glaxo (WAG) normotensives in the response of corticosterone to the injection of the neuromediators serotonin, noradrenaline, and agonists of the adrenergic receptors into the brain ventricle (Markel et al 1999).…”