Endocrine Function in Nineteen Patients with Empty Sella Syndrome

Brisman, Ronald; Hughes, James E. O.; Holub, Donald A.

doi:10.1210/jcem-34-3-570

Cited by 79 publications

(18 citation statements)

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“…PES has been reported to be associated with obesity and hypertension (23), particularly in females (8). In various series of PES, the percentage of obese hypertensive females achieved 70-80% (24).…”

Section: Upper Sellar Factorsmentioning

confidence: 99%

DIAGNOSIS OF ENDOCRINE DISEASE: Primary empty sella: a comprehensive review

Chiloiro¹,

Giampietro²,

Bianchi³

et al. 2017

European Journal of Endocrinology

113

149

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Primary empty sella (PES) is characterized by the herniation of the subarachnoid space within the sella, which is often associated with variable degrees of flattening of the pituitary gland in patients without previous pituitary pathologies. PES pathogenetic mechanisms are not well known but seem to be due to a sellar diaphragm incompetence, associated to the occurrence of upper sellar or pituitary factors, as intracranial hypertension and change of pituitary volume. As PES represents in a majority of cases, a neuroradiological findings without any clinical implication, the occurrence of endocrine, neurological and opthalmological symptoms, due to the above describes anatomical alteration, which delineates from the so called PES syndrome. Headache, irregular menses, overweight/obesity and visual disturbances compose the typical picture of PES syndrome and can be the manifestation of an intracranial hypertension, often associated with PES. Although hyperprolactinemia and growth hormone deficit represent the most common endocrine abnormalities, PES syndrome is characterized by heterogeneity both in clinical manifestation and hormonal alterations and can sometime reach severe extremes, as occurrence of papilledema, cerebrospinal fluid rhinorrhea and worsening of visual acuity. Consequently, a multidisciplinary approach, with the integration of endocrine, neurologic and ophthalmologic expertise, is strongly advocated and recommended for a properly diagnosis, management, treatment and follow-up of PES syndrome and all of the related abnormalities.

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Section: Upper Sellar Factorsmentioning

confidence: 99%

DIAGNOSIS OF ENDOCRINE DISEASE: Primary empty sella: a comprehensive review

Chiloiro¹,

Giampietro²,

Bianchi³

et al. 2017

European Journal of Endocrinology

113

149

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“…On the other hand, pregnancy could promote the onset of PES (21,22). In fact, the pituitary volume could double during pregnancy, particularly in the case of multiple pregnancies (23).…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Primary Empty Sella

Marinis¹,

Bonadonna

Bianchi³

et al. 2005

The Journal of Clinical Endocrinology & Metabolism

213

209

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“…The few reported studies of pituitary function with the 'empty' sella have varied from complete normality to frank anterior hypopituitarism (Caplan & Dobben, 1969) though the deficiency is usually mild (Brisman, Hughes & Holub, 1972). To our knowledge, there have been no reports of the co-existence of posterior pituitary dysfunction and for this reason the following case is reported.…”

Section: Introductionmentioning

confidence: 87%

Diabetes insipidus associated with an empty sella turcica

Matisonn

Pimstone

1973

Postgraduate Medical Journal

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Summary A patient with severe diabetes insipidus for 14 years was found to have an enlarged and eroded sella turcica with greatly reduced pituitary tissue on pneumo-encephalography. It is suggested that the permanent diabetes insipidus may have resulted from growth of an intrasellar tumour, which subsequently infarcted spontaneously. Thyroid and pituitary-adrenal function nevertheless remained good, which accounts for persistence of the diabetes insipidus.

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Endocrine Function in Nineteen Patients with Empty Sella Syndrome

Cited by 79 publications

References 0 publications

DIAGNOSIS OF ENDOCRINE DISEASE: Primary empty sella: a comprehensive review

DIAGNOSIS OF ENDOCRINE DISEASE: Primary empty sella: a comprehensive review

Primary Empty Sella

Diabetes insipidus associated with an empty sella turcica

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