Endocrine effects of psychological stress associated with neurobehavioral performance testing

Mutti, Antonio; Ferroni, C.; Vescovi, Pier Paolo; Bottazzi, Ricardo; Selis, Luisella; Gerra, Gilberto; Franchini, I

doi:10.1016/0024-3205(89)90300-7

Cited by 37 publications

(16 citation statements)

References 10 publications

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“…The catecholamine response to stress in children with anxiety disorder might be responsible for PRL inhibition during the task [68,69]. A similar PRL response to psychological performance testing with a significant reduction of plasma levels was reported in detoxified heroin addicts in relationship with NE and EPI increases [70].…”

Section: Discussionmentioning

confidence: 56%

Neuroendocrine Responses to Psychological Stress in Adolescents with Anxiety Disorder

Gerra¹,

Zaimovic²,

Zambelli³

et al. 2000

Neuropsychobiology

140

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Neurotransmitter-neuroendocrine and cardiovascular responses to the administration of a psychologically stressful mixed-model test (Mental Arithmetic, Stroop Color Word Interference Task, Trier Social Stress Test) were examined in 20 male peripubertal subjects affected by anxiety disorder (group A: 14 with generalized anxiety disorder, 6 with generalized anxiety disorder and separation anxiety disorder) and 20 junior school adolescents, matched for age, without overt psychological disorders (group B). Plasma levels of norepinephrine (NE), epinephrine (EPI), adrenocorticotropic hormone (ACTH), β-endorphin (β-EP), cortisol (CORT), growth hormone (GH), prolactin (PRL) and testosterone (Te) were measured immediately before the beginning of the tests and 30 min later at their end. Mean prestress values of GH, PRL, β-EP and ACTH were significantly higher in anxious subjects than in controls. There was no difference in NE, EPI, CORT and Te prestress levels in the two groups. After the psychological stress session NE, GH and Te concentrations increased significantly in anxious subjects (A), but not in controls. In contrast, β-EP and PRL decreased significantly during the psychological stress session in anxious subjects, and were unaffected by stress in the subjects without anxiety. No significant changes were found in ACTH, CORT and EPI during the challenge either in anxious subjects or in controls, which may be attributed to the late time of poststress blood sampling. In contrast to controls, heart rate and systolic blood pressure increased significantly in anxious subjects after psychological stress testing. Our data support the hypothesis that the hyperactivity of the noradrenergic system in response to stress is associated with anxiety disorders in adolescents and might influence the responses of GH and Te. High prestress basal values of stress hormones seem to be induced in anxious subjects by the anticipation of the task or by a persistent hyperactivity of the noradrenergic system. Further studies are needed to investigate in more detail the involvement of the HPA axis in anxious adolescents by a more refined resolution of time points of blood sampling.

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Section: Discussionmentioning

confidence: 56%

Neuroendocrine Responses to Psychological Stress in Adolescents with Anxiety Disorder

Gerra¹,

Zaimovic²,

Zambelli³

et al. 2000

Neuropsychobiology

140

View full text Add to dashboard Cite

show abstract

“…Investigators have documented elevations in EPI and NE from the SA axis (Gerra et al 2001;Schoder et al 2000) and CORT from the HPA axis (Gerra et al 2001;Miller et al 1993;Mutti et al 1989) in response to mental stressors. Hormonal responses to the physical stress of exercise (acute physiological stress) include a curvilinear NE increase in response to increased workload, and increases in EPI at workloads over 60% VO 2 max (Frankenhaeuser 1991).…”

Section: Introductionmentioning

confidence: 98%

Psychological stress during exercise: cardiorespiratory and hormonal responses

et al. 2008

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The purpose of this study was to examine the cardiorespiratory (CR) and stress hormone responses to a combined physical and mental stress. Eight participants (VO2(max) = 41.24 +/- 6.20 ml kg(-1) min(-1)) completed two experimental conditions, a treatment condition including a 37 min ride at 60% of VO2(max) with participants responding to a computerized mental challenge dual stress condition (DSC) and a control condition of the same duration and intensity without the mental challenge exercise alone condition (EAC). Significant interactions across time were found for CR responses, with heart rate, ventilation, and respiration rate demonstrating higher increases in the DSC. Additionally, norepinephrine was significantly greater in the DSC at the end of the combined challenge. Furthermore, cortisol area-under-the-curve (AUC) was also significantly elevated during the DSC. These results demonstrate that a mental challenge during exercise can exacerbate the stress response, including the release of hormones that have been linked to negative health consequences (cardiovascular, metabolic, autoimmune illnesses).

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“…Consistent with this multidimensional theory of anxiety, Martens et al [34] developed a sport anxiety scale, the CSAI-2, to differentiate between the cognitive and somatic components of state anxiety and self-confidence, when investigating anxiety components during a competition. The functional relationships between psychological stress reactions, SN and SAM responses and HPA axis activation have been extensively investigated both during experimental laboratory sessions [16,[35][36][37]. Competitive parachute jumping is an acute, intensive stress situation, which has been employed by several investigators as a real-life stress situation [32,[38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Effects of Emotional Stress on Neuroendocrine and Autonomic Functions in Skydiving

AValenzano¹,

Moscatelli²,

Triggiani³

et al. 2015

J Psychiatry

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Endocrine effects of psychological stress associated with neurobehavioral performance testing

Cited by 37 publications

References 10 publications

Neuroendocrine Responses to Psychological Stress in Adolescents with Anxiety Disorder

Neuroendocrine Responses to Psychological Stress in Adolescents with Anxiety Disorder

Psychological stress during exercise: cardiorespiratory and hormonal responses

Effects of Emotional Stress on Neuroendocrine and Autonomic Functions in Skydiving

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