Endocrine Effects of Coffee Consumption

Abstract

North Europeans. Boiled coffee is frequently consumed by the inhabitants of the Balkan area, Ireland, North Africa, and Turkey. Scientists have extracted numerous bioactive compounds, such as chlorogenic acids (CGA), polyphenols, diterpenes, caffeine, and caffeine metabolites (1,2) from this complex beverage.

Metabolomic Changes after Coffee Consumption: New Paths on the Block

“…The link between coffee and steroid metabolism is not new and has been largely studied mainly because of the possible association with female cancer risk [ 62–66 ] and adverse effects during pregnancy. [ 67,68 ] In particular, in the present study, an impact on steroid hormone biosynthesis and augmented levels of progesterone, estriol, (carboxymethyl)estrone, methoxy‐estradiol glucosiduronic acid, and estriol glucuronide (Table 1) were reported. While most are inactive metabolites usually excreted in the urine, progesterone and estriol are hormones that can affect human health, particularly in female subjects in delicate conditions, such as pregnancy, lactation, or menopause.…”

Metabolomic changes after coffee consumption: new paths on the block

“…The link between coffee and steroid metabolism is not new and has been largely studied mainly because of the possible association with female cancer risk (Ferrini & Barrett-Connor, 1996;Kotsopoulos et al, 2009;Larsson et al, 2009;Lucero et al, 2001;Sisti et al, 2015) and adverse effects during pregnancy (Dinçer et al, 2020;Doepker et al, 2018). In particular, in the present study, an impact on steroid hormone biosynthesis and augmented levels of progesterone, estriol, (carboxymethyl)estrone, methoxy-estradiol glucosiduronic acid and estriol glucuronide (Table 1) were reported.…”