Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Séralini, Gilles‐Éric; Jungers, Gérald

doi:10.1016/j.toxrep.2021.07.014

Cited by 34 publications

(12 citation statements)

References 411 publications

(448 reference statements)

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“…According to literature, all the 177 EDC identified internationally by WHO also have an impact on the nervous system, thus may be collectively termed endocrine and nervous disruptors [9] , [10] , [11] , [12] , [13] , [14] .…”

Section: Introductionmentioning

confidence: 99%

Occurrence, ecological risk assessment and source apportionment of pharmaceuticals, steroid hormones and xenoestrogens in the Ghanaian aquatic environments

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Occurrence, ecological risk assessment and source apportionment of pharmaceuticals, steroid hormones and xenoestrogens in the Ghanaian aquatic environments

et al. 2022

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“…Each of these compounds has been associated with biomarkers of endocrine disruption in laboratory studies [ 56 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ]. Disruption of normal hormone synthesis and signaling can have widespread effects in whole animals, including defects or dysfunction of the cardiovascular, nervous, and immune systems [ 80 , 81 , 82 , 83 , 84 , 85 ]. It is evident that for many known and suspected endocrine-disrupting compounds, the zebrafish model is sensitive enough to detect bioactivity even in the absence of external reproductive organs.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Multi-System Approach to Characterizing Bioactivity of Commonly Occurring Chemicals

Rivera

Wilson

Kim

et al. 2022

IJERPH

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A 2019 retrospective study analyzed wristband personal samplers from fourteen different communities across three different continents for over 1530 organic chemicals. Investigators identified fourteen chemicals (G14) detected in over 50% of personal samplers. The G14 represent a group of chemicals that individuals are commonly exposed to, and are mainly associated with consumer products including plasticizers, fragrances, flame retardants, and pesticides. The high frequency of exposure to these chemicals raises questions of their potential adverse human health effects. Additionally, the possibility of exposure to mixtures of these chemicals is likely due to their co-occurrence; thus, the potential for mixtures to induce differential bioactivity warrants further investigation. This study describes a novel approach to broadly evaluate the hazards of personal chemical exposures by coupling data from personal sampling devices with high-throughput bioactivity screenings using in vitro and non-mammalian in vivo models. To account for species and sensitivity differences, screening was conducted using primary normal human bronchial epithelial (NHBE) cells and early life-stage zebrafish. Mixtures of the G14 and most potent G14 chemicals were created to assess potential mixture effects. Chemical bioactivity was dependent on the model system, with five and eleven chemicals deemed bioactive in NHBE and zebrafish, respectively, supporting the use of a multi-system approach for bioactivity testing and highlighting sensitivity differences between the models. In both NHBE and zebrafish, mixture effects were observed when screening mixtures of the most potent chemicals. Observations of BMC-based mixtures in NHBE (NHBE BMC Mix) and zebrafish (ZF BMC Mix) suggested antagonistic effects. In this study, consumer product-related chemicals were prioritized for bioactivity screening using personal exposure data. High-throughput high-content screening was utilized to assess the chemical bioactivity and mixture effects of the most potent chemicals.

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“…The relevance of this public consultation and the related legislation under both public law and public health perspectives is strong. The key goals in this update of the CLP legislation are: to adequately address a well-known hazard class (and mode of action) of chemical contaminants, endocrine disruptors [ [15] , [16] , [17] ]; to take into account the effects of mixtures of chemicals [ [18] , [19] , [20] , [21] ]; to account for reduced use of animals in laboratory toxicological testing; and to expand the criteria for toxicological risk assessment and legal control of chemicals, i.e. their environmental persistency, bioaccumulation, and toxicity.…”

Section: Revision Of Clp Regulationmentioning

confidence: 99%

Updating the European Union’s regulation on classification, labelling and packaging of substances and mixtures (CLP): A key opportunity for consumers, workers and stakeholders with interests in the legislation and toxicology of hazardous chemicals

et al. 2021

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Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

Abstract: Graphical abstract

Cited by 34 publications

References 411 publications

Occurrence, ecological risk assessment and source apportionment of pharmaceuticals, steroid hormones and xenoestrogens in the Ghanaian aquatic environments

Occurrence, ecological risk assessment and source apportionment of pharmaceuticals, steroid hormones and xenoestrogens in the Ghanaian aquatic environments

A Comparative Multi-System Approach to Characterizing Bioactivity of Commonly Occurring Chemicals

Updating the European Union’s regulation on classification, labelling and packaging of substances and mixtures (CLP): A key opportunity for consumers, workers and stakeholders with interests in the legislation and toxicology of hazardous chemicals

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