Endocrine-disrupting effects of bisphenols on urological cancers

Pellerin, Ève; Caneparo, Christophe; Chabaud, Stéphane; Bolduc, Stéphane; Pelletier, Martin

doi:10.1016/j.envres.2020.110485

Cited by 23 publications

(14 citation statements)

References 116 publications

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“…Various nanomaterials have been linked to endocrine disruptors or endocrine-disrupting chemicals (EDCs) which represent a large, heterogeneous, yet incompletely understood group of structures acting on normal and pathological body pathways such as hormonal production, secretion, transport, activation/inactivation, receptor binding and feedback regulation (1)(2)(3). This is an ongoing topic of discussion due to a high variety of nanotechnology-related molecules that mimic, block or antagonize the organs or tissues of humans and/or animals and thus an increase or a deficiency of physiological organism pathways of regulation is identified (1)(2)(3). EDCs are part of pollutants that dysregulate the functions of cells representing an emerging public health issue (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

“…This is an ongoing topic of discussion due to a high variety of nanotechnology-related molecules that mimic, block or antagonize the organs or tissues of humans and/or animals and thus an increase or a deficiency of physiological organism pathways of regulation is identified (1)(2)(3). EDCs are part of pollutants that dysregulate the functions of cells representing an emerging public health issue (1)(2)(3). However, a large amount of data remain a matter of debate or remain incompletely known while a close collaboration of biotechnology specialists with clinicians and researchers of different medical fields is essential on this particular topic (1)(2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

“…EDCs are part of pollutants that dysregulate the functions of cells representing an emerging public health issue (1)(2)(3). However, a large amount of data remain a matter of debate or remain incompletely known while a close collaboration of biotechnology specialists with clinicians and researchers of different medical fields is essential on this particular topic (1)(2)(3)(4). Other areas that actually have a lack of feasible information are the methods and protocols existing thus far to routinely assess the effect of EDCs on human and animal bodies (5).…”

Section: Introductionmentioning

confidence: 99%

“…Another largely described family of EDCs acting as carcinogenic promoters is represented by bisphenols which are identified in various products; they impair multiple biological functions such as hormonal secretion or cell growth, including steroid receptors (2). By contrast, enzymatic nanoreactors such as virus-like particles (VLP) identify the EDC-induced damage at the level of natural defense chains including activity of cytochrome P450 enzymes involved in oxidative stress and glucose metabolism (3). Exposure to industry-derived palladium nanoparticles (Pd-NPs) reveals EDC potential, particularly by impairing the gonadal axes (3).…”

Section: Introductionmentioning

confidence: 99%

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Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

et al. 2022

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Various plasticizers and nanomaterials have been linked to endocrine disruptors or endocrine-disrupting chemicals (EDCs) which represent a large, heterogeneous, yet incompletely understood group of structures acting on normal and pathological body pathways such as hormonal production, secretion, transport and receptor binding. By contrast, various applications of nanoparticles are currently under investigation since the delivery of useful drugs, particularly insulin in diabetes mellitus, is essential in case of insulin deficiency. The aim of the present review was to introduce and examine different plasticizers and nanomaterials with potential applications for diabetic patients (such as selenium or gold-based nanoparticles that help the oral delivery of insulin) or plasticizers/nanomaterials acting similarly to EDCs in relation to the human and animal body, particularly glucose metabolism impairment such as diabetes mellitus (DM). Bisphenol A is a chemical used worldwide; however, the effect of exposure varies with regard to the source, environment, time of exposure and the age of the organism. Daily exposure is mostly related to food and drinks stored in polycarbonate plastics. However, exposure may also be through the skin or through the maternal placenta or breast milk which are risk factors for the fetus and for the newborn. It exerts an estrogen-like profile, but it also induces insulin resistance by impairing peripheral insulin receptors or it decreases insulin secretion by acting at the level of insulin-secreting pancreatic β-cells. Phthalates, compounds of flexible plastics, act as EDCs via their human metabolites such as diethyl phthalate and derivative monoethyl phthalate. Their role in inducing gestational DM and weight gain/obesity during pregnancy has been showcased. The vast field of plasticizers and nanomolecules acting as endocrine disruptors is widely linked to clinical aspects of DM, a serious condition with a major population impact. The importance of understanding and using these agents and applications is reflected in saving numerous human lives. Contents 1. Introduction 2. Diabetes mellitus (DM): Past and future 3. Conclusions

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

et al. 2022

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“…Bladder tissue is not recognized as a hormone-dependent tissue, but studies have shown that ERs and the AR are involved in bladder cancer initiation and progression [8,9]. Considering the presence of BPA in urine and the presence of steroid receptors in the bladder urothelium, BPA could have a potential role in bladder cancer development [10].…”

Section: Introductionmentioning

confidence: 99%

Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression

Pellerin

Chabaud

Pouliot

et al. 2021

Cancers

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Bisphenol A (BPA) is an endocrine-disrupting molecule used in plastics. Through its release in food and the environment, BPA can be found in humans and is mostly excreted in urine. The bladder is therefore continuously exposed to this compound. BPA can bind to multiple cell receptors involved in proliferation, migration and invasion pathways, and exposure to BPA is associated with cancer progression. Considering the physiological concentrations of BPA in urine, we tested the effect of nanomolar concentrations of BPA on the metabolism of bladder fibroblasts and cancer-associated fibroblasts (CAFs). Our results show that BPA led to a decreased metabolism in fibroblasts, which could alter the extracellular matrix. Furthermore, CAF induction triggered a metabolic switch, similar to the Warburg effect described in cancer cells. Additionally, we demonstrated that nanomolar concentrations of BPA could exacerbate this metabolic switch observed in CAFs via an increased glycolytic metabolism, leading to greater acidification of the extracellular environment. These findings suggest that chronic exposure to BPA could promote cancer progression through an alteration of the metabolism of stromal cells.

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Bisphenol A regulates bladder cells responses via control of G2/M‐phase cell cycle, apoptotic signaling, MAPK pathway, and transcription factor‐associated MMP modulation

Song,

Hwang,

Park

et al. 2024

J Biochem & Molecular Tox

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Bisphenol A (BPA), an exogenous endocrine‐disrupting chemical, is widely used to produce polycarbonate plastics. The widely used BPA has been detected in human urine samples, raising public anxiety about the detrimental effects of BPA on the bladder. In this study, we explored regulatory mechanisms for the adverse effects of BPA in human bladder BdFC and T24 cells. BPA induced extrinsic and intrinsic apoptosis and G2/M cell cycle arrest caused by the ATM‐CHK1/CHK2‐CDC25c‐CDC2 signaling, which ultimately inhibited the growth of human bladder cells. We also found that BPA decreased the binding activity of AP‐1 and NF‐κB transcription factors in human bladder cells, which inhibited migration and invasion through matrix metallopeptidase‐2 and ‐9 inactivation. Phosphorylation of MAPKs was implicated with BPA‐mediated detrimental effects in human bladder cells. Collectively, our results provide a novel explanation for the underlying molecular mechanisms that BPA induces cytotoxicity in human bladder cells.

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Endocrine-disrupting effects of bisphenols on urological cancers

Cited by 23 publications

References 116 publications

Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

Diabetes mellitus: Plasticizers and nanomaterials acting as endocrine‑disrupting chemicals (Review)

Bisphenol A Alters the Energy Metabolism of Stromal Cells and Could Promote Bladder Cancer Progression

Bisphenol A regulates bladder cells responses via control of G2/M‐phase cell cycle, apoptotic signaling, MAPK pathway, and transcription factor‐associated MMP modulation

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