Endocrine-Disrupting Chemicals and Human Growth and Maturation

Fudvoye, Julie; Bourguignon, Jean-Pierre; Parent, Anne-Simone

doi:10.1016/b978-0-12-800095-3.00001-8

Cited by 53 publications

(27 citation statements)

References 116 publications

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“…Perinatal and prenatal exposures have also been shown to result in excessive weight gain and adipose tissue mass in offspring (30, 31, 38–47). Human studies have demonstrated a positive association between EDC exposures and obesity, increased weight circumference, or increased body mass index (28, 30, 40, 42, 48–65). …”

Section: Adipogenesismentioning

confidence: 99%

“…Several EDCs have been shown to upregulate MSC and preadipocyte differentiation into adipocytes at concentrations ranging from 100 pM to 100 μM: dichlorodiphenyltrichloroethane or 1,1,1-trichloro-2,2-bis ( p -chlorophenyl)-ethane (DDT), 4-nonylphenol (4-NP), octylphenol (OP), bisphenol A (BPA), polychlorinated biphenyl (PCB)-77, PCB-101, PCB-153, PCB-180, di-(2-ethyl hexyl)phthalate (DEHP), mono-(2-ethylhexyl)phthalate (MEHP), dibutyl phthalate (DBP), benzyl butyl phthalate (BBP), dicyclohexyl phthalate (DCHP), and mono-benzyl phthalate (MBzP) (30, 35, 37, 39, 40, 42, 43, 46, 63, 66–80). Many endocrine disruptors target PPARγ by binding to it directly to activate downstream cascades that lead to enhanced adipogenesis or by increasing PPARγ expression to allow for a lower threshold for activation.…”

Section: Adipogenesismentioning

confidence: 99%

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The Effects of Endocrine Disruptors on Adipogenesis and Osteogenesis in Mesenchymal Stem Cells: A Review

et al. 2017

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Endocrine-disrupting chemicals (EDCs) are prevalent in the environment, and epidemiologic studies have suggested that human exposure is linked to chronic diseases, such as obesity and diabetes. In vitro experiments have further demonstrated that EDCs promote changes in mesenchymal stem cells (MSCs), leading to increases in adipogenic differentiation, decreases in osteogenic differentiation, activation of pro-inflammatory cytokines, increases in oxidative stress, and epigenetic changes. Studies have also shown alteration in trophic factor production, differentiation ability, and immunomodulatory capacity of MSCs, which have significant implications to the current studies exploring MSCs for tissue engineering and regenerative medicine applications and the treatment of inflammatory conditions. Thus, the consideration of the effects of EDCs on MSCs is vital when determining potential therapeutic uses of MSCs, as increased exposure to EDCs may cause MSCs to be less effective therapeutically. This review focuses on the adipogenic and osteogenic differentiation effects of EDCs as these are most relevant to the therapeutic uses of MSCs in tissue engineering, regenerative medicine, and inflammatory conditions. This review will highlight the effects of EDCs, including organophosphates, plasticizers, industrial surfactants, coolants, and lubricants, on MSC biology.

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Section: Adipogenesismentioning

confidence: 99%

Section: Adipogenesismentioning

confidence: 99%

The Effects of Endocrine Disruptors on Adipogenesis and Osteogenesis in Mesenchymal Stem Cells: A Review

et al. 2017

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“…It has long been suspected that a number of endocrine disruptors hinder the reproduction and development of humans and wild life, disturbing the transfer of correct phenotypes to the next generations (Gore, 2008;Schug et al, 2011;Frye et al, 2012;Fudvoye et al, 2014). However, the detailed mechanism as well as the exact magnitude of their adverse effects on reproduction is not yet fully understood.…”

Section: Introductionmentioning

confidence: 99%

Effect of <i>in utero</i> exposure to endocrine disruptors on fetal steroidogenesis governed by the pituitary-gonad axis: a study in rats using different ways of administration

et al. 2015

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-The effects of endocrine disruptors on testicular steroidogenesis in fetal rats were investigated in a study involving in utero exposure. In the major part of this study, pregnant rats at gestational day (GD)15 were given a single oral administration of the test substance, and then the expression of the following mRNAs in GD20 fetuses was determined: testicular steroidogenic acute-regulatory protein (StAR), a cholesterol transporter mediating the rate-limiting step of steroidogenesis, a ß-subunit of pituitary luteinizing hormone (LH), and a regulator of gonadal steroidogenesis. Among the substances tested, only di(2-ethylhexyl)phthalate (DEHP) reduced the expression of fetal testicular StAR. The others listed below exhibited little effect on fetal StAR: 2,2',4,4'-tetrabromodiphenylether, tributyltin chloride, atrazine, permethrin, cadmium chloride (Cd), lead acetate (Pb) and methylmercury (CH 3 HgOH). None of them, including DEHP, lacked the ability to reduce the expression of pituitary LHß mRNA. The present study also examined the potential of metals as modifiers of fetal steroidogenesis by giving them to pregnant dams in drinking water during GD1 and GD20. Under these conditions, Cd and Pb at a low concentration (0.01 ppm) significantly attenuated the fetal testicular expression of StAR mRNA without a concomitant reduction in LHß. No such effect was detected with CH 3 HgOH even at 1 ppm. These results suggest that: 1) DEHP, Cd and Pb attenuate the fetal production of sex steroids by directly acting on the testis, and 2) chronic treatment during the entire gestational period is more useful than a single administration for determining the hazardous effect of a suspected endocrine disruptor on fetal steroidogenesis.

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“…In addition to the PCBs themselves, their metabolites can also cross the placenta and reach the developing fetus (Fängström et al, 2005;Soechitram et al, 2004;Berg et al, 2010;Grimm et al, 2015). Exposure to PCBs during intrauterine life has been associated, in humans and animals, with several health effects such as birth weight reduction, disruption of reproductive system development, immune dysfunction, and altered brain development (Schantz et al, 2003;Fowler et al, 2008;Fudvoye et al, 2014;Lignell et al, 2016;Kristensen et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Polychlorinated biphenyls (PCBs) alter DNA methylation and genomic integrity of sheep fetal cells in a simplified in vitro model of pregnancy exposure

Anzalone

Sampino

Czernik

et al. 2018

Toxicology in Vitro

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A B S T R A C TPolychlorinated biphenyls (PCBs) are persistent organic pollutants ubiquitously detectable in the environment and in the food chain. Prenatal exposure to PCBs negatively affects fetal development and produces long-term detrimental effects on child health. The present study sought to evaluate the cytotoxic and genotoxic effects of chronic PCB exposure on fetal cells during pregnancy. To this aim, sheep embryonic fibroblasts (SEF) and amniocytes (SA) were cultured in vitro in the presence of low doses of PCBs for a period of 120 days, comparable to the full term of ovine pregnancy. Cellular proliferation rates, global DNA methylation, chromosome integrity, and markers of DNA damage were evaluated at different time points. Moreover, SEF treated with PCBs for 60 days were left untreated for one further month and then examined in order to evaluate the reversibility of PCB-induced epigenetic defects. PCB-treated SEF were more sensitive than SA treated with PCBs, in terms of low cell proliferation, and increased DNA damage and global DNA methylation, which were still detectable after interruption of PCB treatment. These data indicate that chronic exposure of fetal cells to PCBs causes permanent genomic and epigenetic instability, which may influence both prenatal and post-natal growth up to adulthood. Our in vitro model offer a simple and controlled means of studying the effects of different contaminants on fetal cells -one that could set the stage for targeted in vivo studies.

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Endocrine-Disrupting Chemicals and Human Growth and Maturation

Cited by 53 publications

References 116 publications

The Effects of Endocrine Disruptors on Adipogenesis and Osteogenesis in Mesenchymal Stem Cells: A Review

The Effects of Endocrine Disruptors on Adipogenesis and Osteogenesis in Mesenchymal Stem Cells: A Review

Effect of <i>in utero</i> exposure to endocrine disruptors on fetal steroidogenesis governed by the pituitary-gonad axis: a study in rats using different ways of administration

Polychlorinated biphenyls (PCBs) alter DNA methylation and genomic integrity of sheep fetal cells in a simplified in vitro model of pregnancy exposure

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