Endocrine disorders following treatment of childhood brain tumours

Livesey, Emily; Hindmarsh, Peter C.; Brook, C. G. D.; Whitton, Anthony; Bloom, H. J. G.; Tobias, Jeffrey; Godlee, J. N.; Britton, J. Robert

doi:10.1038/bjc.1990.138

Cited by 130 publications

(100 citation statements)

References 21 publications

(23 reference statements)

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“…Livesey et al (117) reported evidence of GHD in 140 of 144 childhood brain tumor survivors treated with cranial radiation. The prevalence of severe growth retardation, defined as standing height below the fifth percentile, is reported in up to 35% of childhood brain tumor survivors and 15% of childhood leukemia survivors (158,185).…”

Section: Endocrine Abnormalitiesmentioning

confidence: 99%

Adverse Late Effects of Childhood Cancer and Its Treatment on Health and Performance

Ness

Gurney

2007

Annu. Rev. Public Health

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More than 12,000 newly diagnosed cases of cancer occur each year in the United States among children ages 20 years or younger, and the current 5-year survival rate is near 80%. An estimated 228,000 among adults 47 years or younger and currently living in the United States had a diagnosis of cancer during childhood or adolescence. Here, we review long-term adverse effects of childhood cancer and its treatment with an emphasis on physical performance and health. We also briefly review existing guidelines that may be used to develop appropriate exercise and diet interventions for childhood cancer survivors. We suggest that there is a need for development of evidencebased, risk-based guidelines and interventions for health promotion among long-term childhood cancer survivors, particularly for those whose physical activity limitations interfere with chances for optimizing their bodies' potential in today's society.

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Section: Endocrine Abnormalitiesmentioning

confidence: 99%

Adverse Late Effects of Childhood Cancer and Its Treatment on Health and Performance

Ness

Gurney

2007

Annu. Rev. Public Health

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“…In a study of 56 patients irradiated for non-pituitary brain tumours in adulthood, Agha et al (Agha et al, 2005) reported variable degrees of hypopituitarism in 41% of patients. In this study (Agha et al, 2005), GH deficiency (32%) was less frequent that that reported in irradiated children (Clayton & Shalet, 1991;Livesey et al, 1990;Samaan et al, 1987), but ACTH (21%), TSH (9%) and gonadotropin (27%) deficiencies were relatively more common than or similar to that reported in cancer survivors irradiated during childhood (Constine et al, 1993;Livesey et al, 1990;Samaan et al, 1987). The differential influence of age is less clearly defined with intensive irradiation, but it appears to follow the same pattern.…”

Section: Introductionmentioning

confidence: 44%

“…Clinically apparent ACTH deficiency occurs in only about 3% of patients receiving a total radiation dose to the h-p axis of 40-50 Gy (Constine et al, 1993;Livesey et al, 1990). In contrast, the frequency of ACTH deficiency in patients treated with intensive irradiation for NPC is significantly higher.…”

Section: Acth Deficiencymentioning

confidence: 83%

“…With radiation doses of less than 50 Gy, the frequency of TSH deficiency remains as low as 3-6%, such as that found in survivors of non-pituitary brain tumours (Livesey et al, 1990;Oberfield et al, 1992). Patients irradiated during adulthood for non-pituitary brain tumours were reported to have 9% rate of secondary hypothyroidism (Agha et al, 2005).…”

Section: Tsh Deficiencymentioning

confidence: 99%

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Endocrine Complications Following Radiotherapy and Chemotherapy for Nasopharyngeal Carcinoma

Darzy¹

2012

Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma

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“…These adverse effects are more severe in younger children, those under 7 years of age being most susceptible (Ellenberg et al, 1987;Anderson et al, 1994;Radcliffe et al, 1992). All these may have deleterious effects upon the young person's self-esteem, sense of well-being and overall health status (Duffner et al, 1985;Livesey et al, 1990). Additionally, the administration of chemotherapy may cause white matter damage with resultant morbidity (Ball et al, 1992).…”

mentioning

confidence: 99%

School behaviour and health status after central nervous system tumours in childhood

Glaser

Rashid²,

Walker³

1997

Br J Cancer

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Summary This study was designed to assess the overall morbidity burden of survival from central nervous system (CNS) tumours and its impact on return to a normal lifestyle. School behaviour and health status of 27 children after treatment for CNS tumours, of 25 of their schoolaged siblings, plus age-and sex-matched controls is reported. Spinetta school behaviour, Lansky play-performance and Health Utilities Index (mark 11 and ll) assessments have been made. Patients had reduced mobility and increased pain levels. They demonstrated a reluctance to participate in organized physical activities. Impaired cognition, emotion and self-esteem were reported. They worried more than controls but attended school willingly, interacted normally with their peers and viewed the future confidently. Their siblings were reluctant to express openly concern for others or feelings of joy. Teachers were reliable proxies for most attributes, notable exceptions being speech and emotion. This is the first study to have assessed the school behaviour of a cohort solely composed of survivors of childhood CNS tumours. The good social reintegration is reassuring and likely to reflect a high level of psychosocial support. However, the results presented identify these young people as a 'special educational needs' group as defined by the 1981 and 1993 Education Acts.

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Endocrine disorders following treatment of childhood brain tumours

Cited by 130 publications

References 21 publications

Adverse Late Effects of Childhood Cancer and Its Treatment on Health and Performance

Adverse Late Effects of Childhood Cancer and Its Treatment on Health and Performance

Endocrine Complications Following Radiotherapy and Chemotherapy for Nasopharyngeal Carcinoma

School behaviour and health status after central nervous system tumours in childhood

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