Endocrine and behavioral effects of neuromedin S

Jászberényi, Miklós; Bagosi, Zsolt; Thurzó, Balázs; Földesi, Imre; Telegdy, Gyula

doi:10.1016/j.yhbeh.2007.08.002

Cited by 34 publications

(21 citation statements)

References 49 publications

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“…In addition, an increase in self-grooming frequency, suggested to be an indicator of anxiety-related behavior (Jaszberenyi et al, 2007;Kalueff and Tuohimaa 2005) was observed in CSC mice only. Interestingly, it was recently shown that grooming co-occurs with increased anxiety in humans (Grant and Christenson 2007).…”

Section: Basalmentioning

confidence: 91%

“…The number of entries performed into the distal part of the OA, shown to represent anxiety-related behavior (Salome et al 2004), the number and the time of head dips performed on the distal part of the OA, and the number of head dips on the entire OA, which are indicative of risk assessment/exploratory behavior (Ohl et al 2001;Salome et al 2006), and the total distance travelled on the OA, for assessment of locomotory behavior (Salome et al 2006), were scored by a trained observer blind to the animals' treatment. Additionally, the number of grooming episodes (cleaning any parts of the body surface with the tongue, teeth, and/or forepaws) (da Cunha et al 2007), which also appears to serve as an important indicator of anxiety and stress-related behavioral paradigm (Jaszberenyi et al 2007), was monitored. Immediately after behavioral testing, the mice were singly housed until perfusion (2 h after OA exposure), to avoid disturbances of their CSC cagemates.…”

Section: Chronic Subordinate Colony (Csc) Housingmentioning

confidence: 99%

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Effect of chronic psychosocial stress-induced by subordinate colony (CSC) housing on brain neuronal activity patterns in mice

Singewald

Nguyen

Neumann

et al. 2009

Stress

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Chronic subordinate colony (CSC) housing has been recently validated as a murine model of chronic psychosocial stress which induces alterations of stress-related parameters including decreased body-weight gain and an increased level of anxiety in comparison with single housed control (SHC) mice. By using immunohistochemical immediate early gene (IEG) mapping we investigated whether CSC housing causes alterations in neuronal activation patterns in limbic areas including the amygdala, hippocampus, septum and the periaqueductal gray (PAG) and hypothalamic paraventricular nucleus (PVN). While CSC housing increased basal Zif-268 expression in the nucleus accumbens shell compared to SHC, IEG responses to subsequent open arm (OA) exposure were attenuated in the ventral and intermediate sub-regions of the lateral septum, parvocellular PVN and the dorsal CA3 region of the hippocampus of CSC compared with SHC mice. In contrast, a potentiated c-Fos response in CSC mice was observed in the dorsomedial PAG after OA exposure. Confirming previous findings obtained on the elevated plus-maze, an enhanced anxiety-related behavior in CSC compared with SHC mice was also observed during OA exposure. In order to investigate the appropriate control conditions for CSC housing, group housed control (GHC) mice were additionally included in the behavioral testing. Interestingly, GHC as well as CSC mice showed significantly less risk assessment/exploratory behavior during OA exposure compared with SHC mice indicating that group housing itself is stressful for mice and not an adequate control for the CSC paradigm. Overall, CSC housing is an ethologically relevant chronic psychosocial stressor which results in an elevated sensitivity to a subsequent novel, aversive challenge. However, the CSC-induced increase in anxiety-related behavior was accompanied by differences in neuronal activation, compared with SHC, in defined sub-regions of brain areas known to be involved in the processing of emotionality and stress responses.

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Section: Basalmentioning

confidence: 91%

Section: Chronic Subordinate Colony (Csc) Housingmentioning

confidence: 99%

Effect of chronic psychosocial stress-induced by subordinate colony (CSC) housing on brain neuronal activity patterns in mice

Singewald

Nguyen

Neumann

et al. 2009

Stress

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“…A high dose of NMS tended to shorten the duration of lying and increased the amount of head shaking, suggesting that it may induce restlessness in this species. In rats, NMS activated grooming 16 and NMU activated grooming and increased overall locomotor activity 11,49 , which are reported to be CRH-mediated 11,16 . In our previous study in cattle, however, intracerebroventricularly administered CRH did not induce either stereotypical grooming or behavioral activation; rather intracerebroventricularly administered AVP induced restlessness including head shaking 54 .…”

Section: Neuromedin U and Neuromedin Smentioning

confidence: 92%

“…Since NMU type-2 receptors are highly expressed in the central nervous system, the physiological roles of these neuropeptides in the central nervous system have been investigated, mainly in rodents. Both neuropeptides activated the HPA axis and induced grooming through the CRH system 11,16 , but only NMU increased locomotor activity 11,49 . Although we showed that CRH was a more potent stimulator of the HPA axis than AVP, as in rodents, behavioral data suggest species differences between cattle and rodents in the central roles of CRH and AVP in regulating behavioral responses under stressful conditions 54 .…”

Section: Neuromedin U and Neuromedin Smentioning

confidence: 99%

Central Regulation of Stress Response in Cattle

Yayou

2012

JARQ

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Useful and biologically meaningful determinants of stress of farm animals at the field level do not exist at present, though quantitative measurement of stress is essential for the farm animals' well-being. At laboratory level using rodents, physiological and behavioral changes induced by stressors and its regulation by the central nervous system have been elucidated in considerable detail. However, it remains unclear whether we could apply that knowledge to species other than rodents. Therefore, we studied several neurotransmitters involved in the regulation of stress response in cattle. Examination of the effects of intracerebroventricularly administered neurotransmitter candidates revealed which component of stress response was induced or reduced. Thus, we identified several stress-inducing neurotransmitters and one stress-reducing neurotransmitter in cattle, and suggested that the regulatory roles of the neurotransmitters on stress response differ from those of other species, as well exemplified by rodents. Furthermore, for the stress-reducing neurotransmitter, oxytocin, we showed for the first time the association between individual differences in behavioral and hypothalamic-pituitary-adrenal (HPA) axis reactivity to acute stressors and basal levels of plasma oxytocin concentration and its reactivity to the stressors. This suggests that oxytocin may be a neurobiological candidate involved in individual differences for stress susceptibility in cattle. Currently, we are examining the association between polymorphism of oxytocin-related genes and individual differences in stress susceptibility. This knowledge will help improve animal welfare by allowing genetic selection for adaptability to the environment.

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“…45 Further studies have demonstrated that NMS plays important roles in 46 modulating circadian rhythm (Mori et al, 2005), body temperature 47 (Peier et al, 2009;Yayou et al, 2009), milk release (Sakamoto et al,48 2008), drinking behavior (Sakamoto et al, 2007;Tachibana et al, 49 2010), stress responses (Jaszberenyi et al, 2007), and reproductive 50 behavior (Vigo et al, 2007;Yayou et al, 2009;Yang et al, 2010) in 51 mammals.…”

mentioning

confidence: 99%