Endocarditis due to Strain of Cardiobacterium hominis Resistant to Erythromycin and Vancomycin

Prior, Richard B.; Spagna, Vincent A.; Perkins, Robert L.

doi:10.1378/chest.75.1.85

Cited by 17 publications

(6 citation statements)

References 4 publications

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“…It should be noted that vancomycin and erythromycin are recommended for prophylaxis of infective endocarditis in patients allergic to penicillins. Failure of prophylaxis with erythromycin for dental extractions may occur in the face of C. hominis resistant to erythromycin and vancomycin (12). A therapy regimen including vancomycin as did the previous successful treatment for ␤-lactamase-producing C. hominis was not suitable for our patient.…”

mentioning

confidence: 92%

Infective Endocarditis Complicated with Progressive Heart Failure due to β-Lactamase-Producing Cardiobacterium hominis

Lu¹,

Hsueh

Hung³

et al. 2000

J Clin Microbiol

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We describe a 66-year-old woman with infective endocarditis due toCardiobacterium hominis whose condition, complicated by severe aortic regurgitation and congestive heart failure, necessitated aortic valve replacement despite treatment with ceftriaxone followed by ciprofloxacin. The blood isolate of C. hominis produced β-lactamase and exhibited high-level resistance to penicillin (MIC, ≧256 μg/ml) and reduced susceptibility to vancomycin (MIC, 8 μg/ml).

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mentioning

confidence: 92%

Infective Endocarditis Complicated with Progressive Heart Failure due to β-Lactamase-Producing Cardiobacterium hominis

Lu¹,

Hsueh

Hung³

et al. 2000

J Clin Microbiol

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“…However, resistance to certain antibiotics, such as vancomyacin and erythromyacin, has been reported. 13 Complications include heart failure, involvement of subaortic and adjacent struc tures, root abscess (52%), cerebral embolization (30%), and mycotic aneurysm formation (10%). Furthermore, patients with a history of IE are at risk for future recurrence.…”

Section: Discussionmentioning

confidence: 99%

Bioprosthetic Aortic Valve Infective Endocarditis

Rodriguez¹

2009

Journal of Diagnostic Medical Sonography

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A woman in her late 50s was admitted to the hospital with a 4-week history of persistent mild cough, intermittent fever and chills, and generalized fatigue. Her past medical history includes hypertension, dyslipidemia, and rheumatic fever as a child with resultant mitral sclerosis and aortic stenosis. Past surgical history includes appendectomy, tonsillectomy, left mastectomy, and a Toronto stentless aortic valve replacement in 2002. Two weeks prior to admission, she had a hypotensive episode considered related to recurrent fever and dehydration.On physical examination, her temperature was 101°F and blood pressure was 107/52. Her weight was stable at 108 pounds. She appeared mildly ill but not in acute distress. Her heart rate was regular at 88, and respirations were 16. Auscultation of the heart revealed a 3/6 systolic ejection murmur heard best at the apex with radiation to the neck. Electrocardiogram demonstrated an old left bundle branch block. Chest X-ray was unremarkable.Infective endocarditis of the aortic valve usually presents with vegetations attached to the ventricular surface of the valve. Vegetations can be large, pedunculated, and freely mobile, making the risk of embolization high. The author reports a case of bioprosthetic aortic valve endocarditis caused by the rare organism Cardiobacterium hominis with an atypical presentation of the vegetation on the aortic surface.

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“…However, resistance to erythromycin and vancomycin has been reported8 and these agents should not be considered appropriate empirical treatment for patients who are allergic to penicillin unless there is good evidence of sensitivity in vitro 18. Definitive differentiation from other members of the HACEK group is also essential, particularly as Actinobacillus actinomycetemcomitans and Haemophilus aphrophilus may be penicillin resistant.…”

Section: Discussionmentioning

confidence: 99%

Late aortic homograft valve endocarditis caused by Cardiobacterium hominis: a case report and review of the literature

Currie

Codispoti

Mankad

et al. 2000

Heart

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An unusual case of Cardiobacterium hominis endocarditis involving an aortic homograft valve is presented. Although the patient was young (a 17 year old man) and showed few of the characteristic features of the disease, the report does illustrate a number of the problems associated with this illness and highlights the need for the careful assessment of apparent culture negative endocarditis. The organism itself is susceptible to most antibiotics but further treatment, including surgery, may be necessary. Patients must therefore be examined repeatedly and assessed for haemodynamic deterioration, valve destruction or embolic phenomena. Homograft valve replacement may oVer some benefits in the setting of aortic valve endocarditis and is therefore an attractive option in this situation. (Heart 2000;83:579-581)

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Endocarditis due to Strain of Cardiobacterium hominis Resistant to Erythromycin and Vancomycin

Cited by 17 publications

References 4 publications

Infective Endocarditis Complicated with Progressive Heart Failure due to β-Lactamase-Producing Cardiobacterium hominis

Infective Endocarditis Complicated with Progressive Heart Failure due to β-Lactamase-Producing Cardiobacterium hominis

Bioprosthetic Aortic Valve Infective Endocarditis

Late aortic homograft valve endocarditis caused by Cardiobacterium hominis: a case report and review of the literature

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