Endocarditis due to Acinetobacter lwoffi on native mitral valve

Valero, Carmen; Fariñas, M C; Palomo, D. García; Mazarrasa, J.C; Macias, J.

doi:10.1016/s0167-5273(99)00006-6

Cited by 11 publications

(9 citation statements)

References 9 publications

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“…A small number of case reports of Acinetobacter endocarditis exist (361,407,461,520,567). Most, but not all, cases have involved prosthetic valves.…”

Section: Other Manifestationsmentioning

confidence: 99%

Acinetobacter baumannii : Emergence of a Successful Pathogen

2008

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SUMMARY Acinetobacter baumannii has emerged as a highly troublesome pathogen for many institutions globally. As a consequence of its immense ability to acquire or upregulate antibiotic drug resistance determinants, it has justifiably been propelled to the forefront of scientific attention. Apart from its predilection for the seriously ill within intensive care units, A. baumannii has more recently caused a range of infectious syndromes in military personnel injured in the Iraq and Afghanistan conflicts. This review details the significant advances that have been made in our understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.

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“…A small number of case reports of Acinetobacter endocarditis exist (361,407,461,520,567). Most, but not all, cases have involved prosthetic valves.…”

Section: Other Manifestationsmentioning

confidence: 99%

Acinetobacter baumannii : Emergence of a Successful Pathogen

2008

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“…Unlike in other bacteria where the formation of biofilms is facilitated by intrinsic factors such as the presence of type IV pili, flagella, curli and fimbriae, in Acinetobacter spp., putative chaperon secretion membrane systems (csms) and putative surface adherence protein regions (sapr) have been reported to be responsible (39,110). The process generally, involves reversible attachment, irreversible attachment, maturation and dispersion.…”

Section: Epidemiology and Ecologymentioning

confidence: 99%

The Ecology, Biology and Pathogenesis of Acinetobacter spp.: An Overview

et al. 2011

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Acinetobacter are a major concern because of their rapid development of resistance to a wide range of antimicrobials, and rapid profundity in transformation, surviving desiccation and persistinge in the environment for a very long time. The organisms are associated with bacteraemia, pulmonary infections, meningitis, diarrhea and notorious nosocomial infections with mortality rates of 20 to 60%. Transmission is via person-to-person contact, water and food contamination, and contaminated hospital equipment. The increasing virulence and rapid development of multidrug resistance by these organisms highlights the need to search for alternatives for chemotherapy. A poor understanding of the organisms and dearth of information about their occurrence especially in developing countries informed the need for this review paper.

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“…Of these, Acinetobacter spp., Pseudomonas spp. and Propionibacterium acnes have been previously documented as causal organisms of IE (22)(23)(24). Regarding P. acnes, this organism was detected conventionally in 2 sets of blood Analysis of patients' medical history with respect to culture and molecular ndings…”

Section: Comparison Of Blood Culture-negati×e Results and Molecular Nmentioning

confidence: 99%

“…(27), where routine diagnosis solely relies on serology and complex and expensive tissue culture techniques. In addition, PCR techniques have aided in the detection of Tropheryma whippelii (28,29) in cases of endocarditis, as there is presently no serodiagnostic test available (22).…”

Section: Discussionmentioning

confidence: 99%

Molecular Diagnosis of Infective Endocarditis?A New Duke's Criterion

Millar

Moore²,

Mallon³

et al. 2001

Scandinavian Journal of Infectious Diseases

167

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The molecular approach of PCR amplification of specific gene targets and universal loci for bacteria (16S rRNA) and fungi (18S, 28S and 5.8S rRNA) and subsequent sequencing was used to identify the possible causal microbial agent(s) in blood culture (47 patients) and heart valve material (30 patients) from patients with suspected infective endocarditis (IE). Culture and molecular results were analysed with respect to the patients' clinical background and the Duke Criteria. The findings demonstrated that: (i) all patients who were definite or possible cases were positive by PCR, even patients whose blood culture and valve material were culture-negative; and (ii) all patients who were rejected as having IE were also negative by PCR, with the exception of 1 patient who had bacteraemia from another source and 5 patients whose blood culture material was believed to contain an environmental contaminant. Direct molecular identification of the aetiological agents responsible for IE from blood culture material may enable specific treatment to commence at an earlier stage of the disease and hence reduce the need for valve replacement. Such a molecular approach may aid in the diagnosis of IE and should therefore be included as an additional major criterion in the Duke's classification scheme.

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Endocarditis due to Acinetobacter lwoffi on native mitral valve

Cited by 11 publications

References 9 publications

Acinetobacter baumannii : Emergence of a Successful Pathogen

Acinetobacter baumannii : Emergence of a Successful Pathogen

The Ecology, Biology and Pathogenesis of Acinetobacter spp.: An Overview

Molecular Diagnosis of Infective Endocarditis?A New Duke's Criterion

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