Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus

Prestifilippo, Juan Pablo; Medina, Vanina Araceli; Mohn, Claudia; Rodríguez, Patricia; Elverdín, Juan C.; Fernández‐Solari, Javier

doi:10.1016/j.archoralbio.2013.04.003

Cited by 12 publications

(6 citation statements)

References 50 publications

(62 reference statements)

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“…A higher incidence of leukoedema and dry mouth was evident in cannabis users compared to the control groups. The other studies were conducted on animals: two papers on rat models [ 89 , 92 ] and one article on pigs [ 88 ]. Pirino et al evaluated the cannabinoid receptor expressions CB 1 and CB 2 after a dietary supplement administration on 32 pigs, reporting an influence of the expression of salivary ducts and secretion of the mandibular glands related to endocannabinoids activity ( Table 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…Dry mouth associated with cannabis abuse is reported to be similar to the one after cigarette smoking, and in most subjects dry mouths appear immediately after cannabis use [ 129 ]. Cannabis use has always been associated with dry mouth and hypo-salivation via a CB 1 /CB 2 receptor-mediated THC effect on the salivary glands cholinergic transmission [ 89 , 92 ]. THC has also been shown to importantly reduce submandibular salivary flow induced by electrical stimulation in dogs [ 150 ].…”

Section: Resultsmentioning

confidence: 99%

“…For instance, in the submandibular gland, basolateral membranes of ductal cells primarily express CB 1 which, however, is also found in the serous cells of mixed acini according to dietary status [ 88 ]. Several pieces of evidence from the Elverdin lab pointed out a negative action of both CB 1 and CB 2 receptor activation in the regulation of saliva secretion [ 89 , 90 , 91 , 92 , 93 ], which might explain the dry mouth sensation always experienced by heavy cannabis users [ 11 ]. These sets of findings were supported by another study showing that endogenous cannabinoid anandamide, by activating CB 1 receptors expressed in rat parotid glands, triggers cAMP accumulation.…”

Section: Introductionmentioning

confidence: 99%

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Cannabinoids Drugs and Oral Health—From Recreational Side-Effects to Medicinal Purposes: A Systematic Review

Bellocchio

Inchingolo

et al. 2021

IJMS

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Background: marijuana, the common name for cannabis sativa preparations, is one of the most consumed drug all over the world, both at therapeutical and recreational levels. With the legalization of medical uses of cannabis in many countries, and even its recreational use in most of these, the prevalence of marijuana use has markedly risen over the last decade. At the same time, there is also a higher prevalence in the health concerns related to cannabis use and abuse. Thus, it is mandatory for oral healthcare operators to know and deal with the consequences and effects of cannabis use on oral cavity health. This review will briefly summarize the components of cannabis and the endocannabinoid system, as well as the cellular and molecular mechanisms of biological cannabis action in human cells and biologic activities on tissues. We will also look into oropharyngeal tissue expression of cannabinoid receptors, together with a putative association of cannabis to several oral diseases. Therefore, this review will elaborate the basic biology and physiology of cannabinoids in human oral tissues with the aim of providing a better comprehension of the effects of its use and abuse on oral health, in order to include cannabinoid usage into dental patient health records as well as good medicinal practice. Methods: the paper selection was performed by PubMed/Medline and EMBASE electronic databases, and reported according to the PRISMA guidelines. The scientific products were included for qualitative analysis. Results: the paper search screened a total of 276 papers. After the initial screening and the eligibility assessment, a total of 32 articles were considered for the qualitative analysis. Conclusions: today, cannabis consumption has been correlated to a higher risk of gingival and periodontal disease, oral infection and cancer of the oral cavity, while the physico-chemical activity has not been completely clarified. Further investigations are necessary to evaluate a therapeutic efficacy of this class of drugs for the promising treatment of several different diseases of the salivary glands and oral diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cannabinoids Drugs and Oral Health—From Recreational Side-Effects to Medicinal Purposes: A Systematic Review

Bellocchio

Inchingolo

et al. 2021

IJMS

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“…Both CB1 and CB2 receptors are implicated in the regulation of saliva secretion (Prestifilippo et al, 2006), (Fernandez-Solari, Prestifilippo, Ossola, Rettori, & Elverdin, 2010;Fernandez-Solari et al, 2009;Prestifilippo, Fernandez-Solari, Medina, Rettori, & Elverdin, 2009;Prestifilippo et al, 2013). CB1 receptor expressed in rat parotid glands can be activated by the endogenous cannabinoid anandamide.…”

Section: Salivary Glandsmentioning

confidence: 99%

“…Most cannabis users have dry mouths immediately after cannabis use. Cannabis caused hyposalivation and dry mouth through the cholinergic effect of THC on the salivary glands mediated by CB1 and CB2 receptors (Prestifilippo et al, 2006(Prestifilippo et al, , 2013. THC can significantly decrease electrical stimulation-induced salivary flow from the submandibular gland in dogs (McConnell, Dewey, Harris, & Borzelleca, 1978).…”

Section: Dry Mouthmentioning

confidence: 99%

The effects of cannabis use on oral health

Liu

Yang

et al. 2019

Oral Diseases

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Cannabis, also known as marijuana, is one of the most commonly used substances for medical and recreational purposes globally. With the trend of global legalization of medical use of cannabis and even the recreational use, the prevalence of recreational use of cannabis has increased markedly over the past few years. Correspondingly, the potential health concerns related to cannabis consumption have also increased. Therefore, it is necessary for oral healthcare providers to understand the effects of cannabis use on oral health. This review briefly summarizes the components of cannabis, biologic activities on tissues, and mechanisms of action in human cells and tissues. Oral tissue expression of cannabinoid receptors and the potential association of cannabis to oral diseases are also examined. The goals of this review are to (1) elaborate the basic biology and physiology of cannabis in human oral tissues, and (2) provide a better understanding the effects of its use and abuse on oral health. Due to insufficient information, more well‐designed studies should be conducted. It is urgent to include cannabis usage into dental patient health records.

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Dietary fatty acids and the time elapsed from their intake are related to their composition in rat submandibular gland and salivary flow rates

et al. 2020

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Endocannabinoids mediate hyposalivation induced by inflammogens in the submandibular glands and hypothalamus

Cited by 12 publications

References 50 publications

Cannabinoids Drugs and Oral Health—From Recreational Side-Effects to Medicinal Purposes: A Systematic Review

Cannabinoids Drugs and Oral Health—From Recreational Side-Effects to Medicinal Purposes: A Systematic Review

The effects of cannabis use on oral health

Dietary fatty acids and the time elapsed from their intake are related to their composition in rat submandibular gland and salivary flow rates

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