Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell–Cell Contact – Role of mGluR5 and TRPC3 Channels

Turunen, Päivi; Louhivuori, Lauri; Louhivuori, Verna; Kukkonen, Jyrki P.; Åkerman, Karl E.O.

doi:10.1016/j.neuroscience.2018.02.005

Cited by 7 publications

(4 citation statements)

References 57 publications

(101 reference statements)

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“…TRPC3 also enhanced melanoma cell migration and tumor formation both in vitro and in vivo [97]. Furthermore, TRPC3, together with mGluR5, has been shown to enhance motility in embryonic neuronal cells as a result of endocannabinoid stimulation [98]. It has also been shown that the invasion of bladder cancer cells is dependent on both TRPC3 and TRPC6.…”

Section: Trpc Channels Migration and Invasionmentioning

confidence: 94%

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Asghar

Törnquist

2020

IJMS

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Calcium (Ca2+) is perhaps the most versatile signaling molecule in cells. Ca2+ regulates a large number of key events in cells, ranging from gene transcription, motility, and contraction, to energy production and channel gating. To accomplish all these different functions, a multitude of channels, pumps, and transporters are necessary. A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These channels are divided into 29 subfamilies, and are differentially expressed in man, rodents, worms, and flies. One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family comprises of seven isoforms, labeled TRPC1–7. In man, six functional forms are expressed (TRPC1, TRPC3–7), whereas TRPC2 is a pseudogene; thus, not functionally expressed. In this review, we will describe the importance of the TRPC channels and their interacting molecular partners in the etiology of cancer, particularly in regard to regulating migration and invasion.

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Section: Trpc Channels Migration and Invasionmentioning

confidence: 94%

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Asghar

Törnquist

2020

IJMS

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“…The migration of neurons into the developing neocortex results in the formation of a six‐layered structure that is ordered by time of migration . Interestingly, Turunen et al found that the increased endogenous production of 2‐Ara‐Gl led to bursts in the mobility of neuroblasts regulated by the metabotropic glutamate receptor 5 (mGluR5) or its transducer canonical transient receptor potential channel 3 (TRPC3) in isolated mice neuronal progenitor stem (NPS) cells . Furthermore, Díaz‐Alonso et al evidenced the key role of the ECS in promoting a correct neuronal migration.…”

Section: The Endocannabinoid Systemmentioning

confidence: 99%

Synthetic cannabinoids and their impact on neurodevelopmental processes

et al. 2019

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Cannabinoids comprise a broad group of psychoactive substances that activate endogenous cannabinoid (EC) receptors (ie, CB 1 R and CB 2 R), altering neurotransmitter release in the brain. The importance of their regulatory role in different biological processes has prompted the development of synthetic cannabinoids (SCs), substantially more potent than tetrahydrocannabinol (THC, the main psychoactive substance of cannabis). Although SCs were primarily designed given their therapeutic applications, their recreational use has become a major public health concern due to several reports of severe intoxications and deaths. SCs have favored increased popularity over recent years due to their intensified psychoactive effects, compared with THC, turning regular cannabis users into SCs. Among cannabinoid users (mainly young people), pregnant women and women of child-bearing potential (WoCBP) comprise particular risk groups, due to the potential onset of neurodevelopment disorders in the offspring (eg, schizophrenia and autism spectrum disorders). Understanding the role played by cannabinoids, and the potential action of emerging SCs in the regulation of the neuronal function, especially during neuronal development, thus assumes critical relevance. Here, we review the mechanistic regulation of neuronal processes, namely during neuronal development, by the endocannabinoid system. Most important, we further develop on the potential of SCs to modulate such mechanisms and subsequently disrupt proper neurodevelopment. KEYWORDScannabinoid receptors, developmental neurotoxicity, endocannabinoid system, neuronal development, new psychoactive substances

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“…AEA is a high‐affinity partial agonist of CB1R and is mostly inactive when bound to CB2R, whereas 2‐AG is a full agonist of both CBRs (Zou and Kumar, 2018) whose structure is strictly recognized by CB2R. The change in 2‐AG affects the distance and rotation frequency among NP cells, which determines the number of contacts between neurons and neurons (Turunen et al, 2018). And by activating CB1R and phosphorylating ERK1/2, 2‐AG not only regulates synapse formation, axonal growth, but also controls the fate, migration, and proliferation of NP cells (Keimpema et al, 2013).…”

Section: Metabolic Pathways and Intracellular Regulation Of Ecbsmentioning

confidence: 99%

Role of the endocannabinoid system in neurological disorders

Zou

et al. 2019

Intl J of Devlp Neuroscience

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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that begins in infancy. Although the etiology and pathogenesis are poorly understood, many studies have shown that ASD is closely related to structural and functional defects in the nervous system, especially synaptic transmission. The endocannabinoid (eCB) system is an important regulatory system of the central nervous system that regulates neurotransmission and synaptic plasticity and plays an important role in emotional and social responses and cognitive function. The relationship between eCB system and ASD has attracted increasing attention from scholars. In this review, we discuss the complex lipid signaling network of the eCB system, intracellular transport pathways, abnormal expression and association with various neurological diseases, and direct and indirect evidence for the link between eCB and ASD. Collectively, the findings to date indicate that the eCB system plays a key role in the pathophysiology of ASD and can provide new insights into potential interventions and rehabilitation strategies for ASD.

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Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell–Cell Contact – Role of mGluR5 and TRPC3 Channels

Cited by 7 publications

References 57 publications

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Transient Receptor Potential Canonical (TRPC) Channels as Modulators of Migration and Invasion

Synthetic cannabinoids and their impact on neurodevelopmental processes

Role of the endocannabinoid system in neurological disorders

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