Endobronchial Valve Therapy in Patients with Homogeneous Emphysema. Results from the IMPACT Study

Abstract

EBV in patients with homogeneous emphysema without collateral ventilation results in clinically meaningful benefits of improved lung function, exercise tolerance, and quality of life.

New bacterial growth in bronchial secretions after bronchoscopic valve implantation

“…However, only 1 out of 5 randomized controlled trials (RCTs) that compared complete occlusion of the lung lobe by valves to standard therapy reported a statistically significant increased rate of COPD exacerbation with hospitalization within 90 days following valve placement. [25][26][27][28][29] However, it is questionable, if the increased exacerbation frequency is primarily due to the valves and the bacterial colonization or due to the bronchoscopic procedure itself. In the remaining 4 RCTs, no statistically significant difference of the COPD exacerbation rate was found between the treatment and the control groups.…”

Reducción de volumen pulmonar endoscópica en enfisema pulmonar avanzado: Casos clínicos

“…Como complicaciones, se reportaron 23 eventos en el grupo de válvulas y 5 en el grupo control (p = 0,001); siendo la presencia de neumotórax la más frecuente (6 en grupo válvulas contra 0 en manejo médico) 12 . Recientemente se publicaron los resultados del estudio IMPACT, en el que se aplicaron válvulas en pacientes con enfisema homogéneo y ausencia de ventilación colateral demostrando que el grupo sometido a VE presentó una diferencia del VEF 1 de 17% a los tres meses, así como mejoría en calidad de vida y tolerancia al ejercicio 13 .…”

Exploration de la fonction pulmonaire par spirométrie

“…297 In a prospective RCT, targeted thermal vapour ablation of more diseased segments resulted in clinically meaningful and statistically significant improvements in lung function and health status at 6 months. COPD exacerbation was the most common serious adverse event.…”