Endobronchial ultrasound-guided lymph node biopsy with transbronchial needle forceps: a pilot study

Herth, Felix J.F.; Schüler, Helena Garcia; Gompelmann, Daniela; Kahn, Nicolas; Gasparini, Stefano; Ernst, Armin; Schuhmann, Maren; Eberhardt, Ralf

doi:10.1183/09031936.00033311

Cited by 63 publications

(44 citation statements)

References 20 publications

(19 reference statements)

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“…Today, with the introduction of real-time endobronchial ultrasound-guided TBNA (EBUS-TBNA) and transesophageal endoscopic ultrasound-guided fine needle aspiration, a higher number of patients is diagnosed with sarcoidosis [3][4][5]. Currently, endobronchial ultrasound (EBUS) is extensively used for mediastinal sampling; however, conventional bronchoscopic techniques are still the first choice in the diagnostic algorithm of sarcoidosis cases in many centers [1].…”

Section: Introductionmentioning

confidence: 99%

The Role of Endobronchial Biopsy in the Diagnosis of Pulmonary Sarcoidosis

Göktalay

Çeli̇k

Alpaydın

et al. 2016

Turk Toraks Dergisi

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OBJECTIVES:This study aimed to investigate the additional diagnostic value of endobronchial biopsy (EBB) in the diagnosis of pulmonary sarcoidosis. MATERIALS AND METHODS:This retrospective cross-sectional study included 59 patients with a preliminary diagnosis of sarcoidosis who were admitted to the Pulmonary Diseases Outpatient Clinic of a tertiary healthcare center between January 2005 and October 2012. The socio-demographic characteristics of the patients as well as clinical and radiological findings were recorded. All patients, irrespective of the presence of an endobronchial lesion (EBL), underwent fiberoptic bronchoscopy (FOB); two to four specimens were taken using EBB from the carina of the right middle lobe in the patients with EBL. RESULTS:Of the patients, 39 (66.1%) had normal bronchoscopic findings, while 5 had EBL. Diagnosis was based on EBB in 11 patients (18.6%). Six patients (15.3%) with normal bronchial mucosae were pathologically diagnosed by EBB. There was no statistically significant relationship between the diagnostic ratio of EBB and disease stage, extrapulmonary involvement, FOB findings, elevated lymphocyte rate in bronchoalveolar lavage (≥ 13%), a CD4/CD8 ratio of ≥ 3.5, and serum angiotensin-converting enzyme (ACE) level (p> 0.05). CONCLUSION:EBB not only offers the advantage of a high diagnostic ratio in patients with mucosal abnormalities but also contributes to pathological diagnosis in patients with normal mucosa. We recommend using EBB to support diagnosis with a low complication rate for patients undergoing FOB with a preliminary diagnosis of sarcoidosis in healthcare centers, where endobronchial ultrasound (EBUS) is unavailable.

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Section: Introductionmentioning

confidence: 99%

The Role of Endobronchial Biopsy in the Diagnosis of Pulmonary Sarcoidosis

Göktalay

Çeli̇k

Alpaydın

et al. 2016

Turk Toraks Dergisi

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“…[22] Histological confirmation and subtyping of lymphoma remains the standard precondition for chemotherapy. TBNA/EBUS-TBNA cell block samples [23] and EBUS transbronchial needle forceps biopsies [24] may overcome these deficiencies. The only study done in the last 10 years evaluating the diagnostic yield of conventional (blind) TBNA in the diagnosis of lymphoma (using cytology and/or histology needles) was by Fernández-Villar et al [25] in 2010, on 15 patients with lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic yield of transbronchial needle aspiration for lymphoma

et al. 2016

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Background. Transbronchial needle aspiration (TBNA) is a minimally invasive bronchoscopic technique that is cost-effective and safe for diagnosing mediastinal and hilar adenopathy in lung cancer, other malignancies, sarcoidosis and infectious processes such as tuberculosis. Few studies have analysed the sensitivity, specificity and predictive values of TBNA for diagnosing lymphoma. Objective. To evaluate the diagnostic yield of TBNA for diagnosing mediastinal and hilar adenopathy in suspected lymphoma. Methods. We performed a retrospective analysis of collected data of patients with mediastinal and hilar adenopathy adjacent to the tracheobronchial tree detected by thoracic computed tomography, who underwent TBNA at Tygerberg Hospital between July 2010 and June 2013. We included 25 patients with suspected or proven lymphoma. Histology was used as the gold standard. Results. Adequate samples for cytological evaluation were obtained for 22 (88%) patients. Cytological diagnosis was possible for 8 (32%). For 17 (68%) who could not be diagnosed by TBNA alone, histology provided final diagnosis. Rapid on-site examination (ROSE) was performed in 23 (92%). In 17/23 (74%) cases, these had similar results to formal cytology. Only 4 (16%) had flow cytometry requested. Twelve (48%) had lymphoma confirmed on histology. TBNA cytology had 100% specificity and positive predictive value for suspicion of lymphoma. Sensitivity was 33% and negative predictive value 62%. Conclusion. TBNA is an appropriate first-line diagnostic procedure in evaluating mediastinal and hilar lymphadenopathy in suspected lymphoma. Biopsy should be the immediate second-line procedure when ROSE/cytology is suspicious of lymphoma or shows atypical cells. Patients with negative TBNA cytology, but high clinical or radiological suspicion of lymphoma, should be further investigated. Respir J 2016;22(3):67-72. S Afr

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“…A necessidade de material histológico de forma simples e eficaz gera a invenção de novas técnicas e equipamentos, que se encontram em fase de avaliação em alguns estudos científicos. [1][2][3][4] Descreve-se o caso clínico de uma doente com lesão mediastínica sólida em que se realizaram pela primeira vez biópsias transtraqueais com intuito diagnóstico.…”

Section: Introductionunclassified

Biópsias Transtraqueais em Neoplasia do Mediastino: Um Método Diagnóstico Viável

Bugalho¹,

Ribeiro²,

Nunes³

et al. 2017

Gaz Med

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RESUMOO diagnóstico de lesões pulmonares e mediastínicas pode ser realizado através de procedimentos minimamente invasivos dos quais se destaca a broncoscopia flexível e a ecoendoscopia brônquica. Descreve-se o caso de uma doente de 65 anos com lesão sólida no mediastino superior e médio em que o diagnóstico de cancro de pulmão de pequenas células foi alcançado por biópsia transtraqueal, um método não convencional mas viável. PALAVRAS-CHAVE

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Endobronchial ultrasound-guided lymph node biopsy with transbronchial needle forceps: a pilot study

Cited by 63 publications

References 20 publications

The Role of Endobronchial Biopsy in the Diagnosis of Pulmonary Sarcoidosis

The Role of Endobronchial Biopsy in the Diagnosis of Pulmonary Sarcoidosis

Diagnostic yield of transbronchial needle aspiration for lymphoma

Biópsias Transtraqueais em Neoplasia do Mediastino: Um Método Diagnóstico Viável

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