Endobronchial metastases secondary to solid tumors: report of eight cases and review of the literature

Katsimbri, Pelagia; Bamias, Aristotle; Froudarakis, Marios; Peponis, Ioannis A.; Constantopoulos, Stavros H.; Pavlidis, Nicholas

doi:10.1016/s0169-5002(99)00134-8

Cited by 97 publications

(108 citation statements)

References 21 publications

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“…9 The average interval of EBM to occur after the diagnosis of primary uterine cervical cancer is 5.4 years. 10,11,12 In two cases reported by Yonsei et al, the interval was 3 and 2.2 years, respectively. 6 In our case, the EBM was detected after an interval of 1.5 years, probably reflecting a more aggressive nature of the disease.…”

Section: Discussionmentioning

confidence: 93%

“…Infrequently they may present with nonspecific pulmonary infiltrates and multiple pulmonary nodules. 7,11,12,13 Fibreoptic bronchoscopy is the most important and simplest diagnostic tool and is essential for the diagnosis of endobronchial lesions, with a very high diagnostic accuracy for centrally located lesions. Also, in a known case of another non-pulmonary malignancy, the presence of persistent pulmonary symptoms warrants a FoB even with normal chest radiographic finding.…”

Section: P16 ×200mentioning

confidence: 99%

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Metachronous endobronchial metastasis from uterine cervical adenocarcinoma

Darling

2018

S. Afr. j. oncol.

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Malignant involvement of the lung can be primary or metastatic. Although primary lung cancer may be endobronchial, parenchymal or both, metastases to the lung are generally parenchymal. However, less commonly, they may be endobronchial. The lungs are the most common site of metastases among all the malignancies. Common extrapulmonary malignancies causing endobronchial metastases (EBMs) are breast, colorectal and kidney. EBMs from uterine cervical cancer are very rare. Although there are a few case reports in the medical literature describing EBM from cervical cancer, none are from adenocarcinoma histology. In this study, we report a case of EBM which on histopathological examination and immunohistochemistry were found to be from a prior adenocarcinoma cervix. Differentiating EBM from bronchogenic carcinoma and other more common extrapulmonary solid organ malignancies may present a clinico-pathological and radiological challenge.

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Section: Discussionmentioning

confidence: 93%

Section: P16 ×200mentioning

confidence: 99%

Metachronous endobronchial metastasis from uterine cervical adenocarcinoma

Darling

2018

S. Afr. j. oncol.

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“…The tumor makes early local metastases, and distant metastases originate generally from the lymph nodes, bone, ovaries, pleura, pericardium, or meninges, but rarely from the lungs. [5][6][7] Pulmonary metastasis is seen in 20% of transitional-cell carcinoma of the bladder. Forty-six percent of these metastases are reported as multiple nodules, 25% as solitary nodules, 17% as infiltrates, 7% as pulmonary edema, 3% as Pancoast tumor.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 The occurence of both transitionalcell and primary signet-ring cell carcinoma together, recognized via respiratory symptoms, and consistent with endobronchial metastasis, is very rare in the literature, so its incidence is not clear. [3][4][5][6] The pulmonary involvement may be parenchymal or lymph node metastasis. Metastatic involvement of the main bronchi cannot be discriminated from bronchogenic carcinoma with central localization by clinical and radiological findings.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, metastases from other sites must be ruled out before a primary signet-ring cell carcinoma of the bladder is diagnosed. [4][5][6] Endobronchial metastasis generally appears as a late finding of a primary tumor, and it is rare to identify an endobronchial metastasis before diagnosing the primary tumor. [1][2][3] The first report related to endobronchial metastatic disease was published in 1890.…”

Section: Introductionmentioning

confidence: 99%

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Endobronchial Metastasis of a Primary Transitional-Cell and Signet-Ring Cell Carcinoma of the Urinary Bladder

Çekmen¹,

Açiksöz²,

Serdaroğlu³

et al. 2011

Respir Care

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Endobronchial metastasis is generally a late finding of primary tumor or may be determined before the diagnosis of primary tumor. We present a rare case of primary transitional and signet-ring cell carcinoma of the urinary bladder that occurred with malignant pleural effusion and endobronchial metastasis. A 71-year-old man complained of dyspnea and hematuria. He was admitted to the intensive care unit (ICU) with a prediagnosis of acute respiratory failure. He had decreased respiratory sounds and fine rales bilaterally at the lung bases. Respiratory failure worsened, and he was placed on mechanical ventilation. Radiograph and computed tomogram revealed bilateral effusion and metastatic nodules in the lung parenchyma. Subsequent abdominal computed tomogram revealed a mass in the urinary bladder, and transurethral biopsy indicated transitional epithelial carcinoma (modified Bergvist grade IIIB, and World Health Organization/International Society of Urological Pathology higher-grade urothelial papillary carcinoma) and signet-ring cell carcinoma, with lymphovascular invasion, consistent with the pathology findings. Our treatment plan was radical cysto-prostatectomy, followed by chemotherapy and radiotherapy, but because of his very poor medical status, the operation was not performed. On the 5th ICU day he died from severe respiratory failure, despite intensive supportive therapy. This case highlights the need to rule out malignancies in other organs in patients admitted with severe respiratory symptoms.

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