Endobronchial Metastasis from Extrapulmonary Neoplasms: Analysis of Clinicopathologic Features and Cytological Evaluation by Bronchial Brushing

Ikemura, Kenji; Lin, Diana Murro; Martyn, Colin; Park, Ji-Weon; Seder, Christopher W.; Gattuso, Paolo

doi:10.1007/s00408-017-0017-2

Cited by 11 publications

(13 citation statements)

References 19 publications

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“…Breast, colon, and renal carcinomas are reported as being most often associated with EBM (25). Although EBM represents an advanced stage of malignancy, it does not necessarily indicate a poorer prognosis than that for malignant tumors without EBM.…”

Section: Discussionmentioning

confidence: 99%

Endobronchial Metastasis of Renal Carcinoma: A Case Report and Review of Previous Literature

Zhang

Chen

et al. 2021

Front. Surg.

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The definition of endobronchial metastasis (EBM) lacks clarity because it is currently based on the judgments of surgeons; it is rare in patients with nonpulmonary malignancies. Although EBM represents an advanced stage of malignancy, it does not necessarily indicate a poorer prognosis than that for its primary tumors. The present study defines EBM as bronchoscopy-visible lesions with histologically confirmed primary extrapulmonary tumors, excluding those primary lung tumors with involvement of the bronchial lumen. A bronchoscopy and biopsy provide strong proof for diagnosis. Complete surgical resection is the best choice for patients with EBM. This study analyzed the case of a 69-year-old male patient who had undergone a radical left nephrectomy several years previously after the identification of a bronchoscopy-visible lesion in the left main bronchus. The lesion was initially diagnosed as an angiogenic tumor but was eventually confirmed by surgical biopsy as EBM from the left kidney. After diagnosis, the patient underwent a left pneumonectomy. The analysis of this case focused on diagnosis, symptoms, radiographic findings, treatment, and prognosis. A review of the previous literature relating to EBM was also conducted.

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Section: Discussionmentioning

confidence: 99%

Endobronchial Metastasis of Renal Carcinoma: A Case Report and Review of Previous Literature

Zhang

Chen

et al. 2021

Front. Surg.

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“…Primary lung cancer is the most common cause of endobronchial tumours. Likewise, many kinds of extrapulmonary primary tumours have been associated with EBM, primarily breast, colon, and renal carcinomas [2–4]. EBMs from testicular seminomas are also extremely rare.…”

Section: Discussionmentioning

confidence: 99%

“…Lung metastases from extrapulmonary malignancies are observed frequently in clinical practice; by contrast, endobronchial metastases (EBMs) from extrapulmonary malignancies are rare and may have distinct histopathological etiologies [1–3]. Primary lung cancer is the most common cause of endobronchial tumours.…”

Section: Introductionmentioning

confidence: 99%

“…Primary lung cancer is the most common cause of endobronchial tumours. Extrapulmonary malignancies that are frequently associated with metastases to the central airways include tumours of breast, colorectal, renal, or thyroid origin [2–5]. Although mediastinal lymphadenopathy is frequently observed in association with testicular seminoma, EBMs from embryonal carcinomas are extremely rare [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Endobronchial metastases from a primary embryonal carcinoma

Teng

Cheng

Chen

et al. 2020

Respirology Case Reports

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We report the case of a 24‐year‐old man who presented with chief complaints of shortness of breath and haemoptysis; chest radiography revealed complete collapse of the left lung. Bronchoscopy revealed an endobronchial tumour with complete obstruction of the left main bronchus. Cryosurgical excision was performed; tissue pathology confirmed the diagnosis of metastatic embryonal carcinoma. The patient underwent a right orchiectomy followed by a bleomycin + etoposide + cisplatin (BEP) chemotherapy regimen.

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“…По мере его накопления выявлены значительные возможности бронхоскопии в диагностике метастатических опухолей бронхов, что касается их эндоскопической семиотики и морфологической верификации. По данным различных авторов [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] частота метастазов злокачественных опухолей в бронхи варьирует от 2 до 28%. Злокачественные опухоли внелегочной ло-кализации метастазируют в бронхи гематогенным или лимфогенным путем, а также подрастают к бронху из прилежащей паренхимы легкого.Чаще всего в бронхиальное дерево метастазируют опухоли молочной железы, почки и толстой кишки.…”

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Endoscopic semiotics of metastatic bronchial tumors

et al. 2021

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Aim. To study the possibilities of bronchoscopy in the detection and evaluation of metastatic lung tumors. Materials and methods. From 2017 to September 2020, 3719 bronchoscopies, including 1081 biopsies during bronchoscopy were performed at the Blokhin National Medical Research Center of Oncology. According to the results of the morphological verification, 40 patients had been diagnosed with lung metastasis. Results. Endobronchial metastatic tumors from extrapulmonary malignancies are quite rare. After had studying 40 cases of metastatic bronchial tumors, we found that the most commonly primary malignancies associated with endobronchial metastases were breast cancer (12 patients), colorectal cancer (6 patients) and thyroid cancer (4 patients). All patients who had been diagnosed with the pathology during the bronchoscopy had been required to make a biopsy for the purpose of morphological verification. Conclusion. The value of bronchoscopy lies in the possibility not only of the detailed visual studying and detecting the tumor pathology of the bronchial tree, but also of obtaining material for morphological analysis. In this regard, the role of biopsy during bronchoscopy is extremely important. In the visual signs of tumor lesion, it is necessary to take multiple biopsies from different parts of the tumor.

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Endobronchial Metastasis from Extrapulmonary Neoplasms: Analysis of Clinicopathologic Features and Cytological Evaluation by Bronchial Brushing

Abstract: Bronchial brushing is a sensitive technique for diagnosing non-hematologic extrapulmonic endobronchial metastases.

Cited by 11 publications

References 19 publications

Endobronchial Metastasis of Renal Carcinoma: A Case Report and Review of Previous Literature

Endobronchial Metastasis of Renal Carcinoma: A Case Report and Review of Previous Literature

Endobronchial metastases from a primary embryonal carcinoma

Endoscopic semiotics of metastatic bronchial tumors

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