Endobiogeny: A Global Approach to Systems Biology (Part 2 of 2)

Abstract

Endobiogeny and the biology of functions are based on four scientific concepts that are known and generally accepted: (1) human physiology is complex and multifactorial and exhibits the properties of a system; (2) the endocrine system manages metabolism, which is the basis of the continuity of life; (3) the metabolic activity managed by the endocrine system results in the output of biomarkers that reflect the functional achievement of specific aspects of metabolism; and (4) when biomarkers are related to each other in ratios, it contextualizes one type of function relative to another to which is it linked anatomically, sequentially, chronologically, biochemically, etc.

A novel approach to modeling tissue-level activity of cortisol levels according to the theory of Endobiogeny, applied to chronic heart failure

“…Stricto senso, it only evaluates metabolic output from the adrenal cortex. Thus, it is suggestive of potential tissue activity but not its actual achieved effects, [10] which depend on a myriad of genetic and epigenetic factors [5,15,16]. Fasting plasma cortisol may not be a reliable indicator of tissue-level cortisol activity [5].…”

“…Because it models net global functional activity, it is not dependent on circadian rhythms and can be drawn at any time. It can be repeatedly performed even within hours of prior samples to evaluate the evolution of cortisol activity in acute and chronic settings [16,17].…”

“…It is claimed by proponents of the theory Endobiogeny that the functional activity of cortisol can be modeled without measuring cortisol in any body fluid [16]. An index has been developed called the Cortisol index (CI).…”

“…It diminishes circulating levels of lymphocytes and eosinophils through sequestration and apoptosis. We have evaluated these studies in detail elsewhere [16]. The cortisol index formula then incorporates the bone marrow products that are increased in the numerator, and those that are diminished by cortisol in the denominator.…”

“…From the theory of endobiogeny a physiologic modeling system has been derived called the biology of functions (BoF). Biomarkers are viewed as downstream products of cellular metabolism and thus indirect markers of upstream regulation of cell and tissue metabolism [16]. The applicability of this global systems approach in CHF patients was recently demonstrated with respect to the neutrophil-to-lymphocyte ratio, referred to as the Genito-thyroid index in Endobiogenic terminology [17].…”