Endemic Mycoses in a Cancer Hospital

Torres, Harrys A.; Rivero, Gustavo; Kontoyiannis, Dimitrios P.

doi:10.1097/00005792-200205000-00004

Cited by 25 publications

(4 citation statements)

References 59 publications

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“…Although the magnitude of the finding is unclear, previous authors have observed a decreased serologic response in immunocompromised hosts who contract coccidioidomycosis [ 3 , 7 – 9 , 17 ]. Some of these studies examined 1 or 2 methods performed in reference laboratories.…”

Section: Discussionmentioning

confidence: 91%

“…Some authors have demonstrated lower rates of seropositivity in immunosuppressed persons [ 7 – 9 ], whereas others have reported evidence that the serologic response is maintained in immunocompromised hosts [ 5 , 10 ]; most of these observations were seen in small case series, had no comparison group, or contained no temporal information. In contrast, our report reviews our experience with each of the 3 serologic methods in both immunocompetent and immunosuppressed persons as a function of time since onset of illness.…”

Section: Introductionmentioning

confidence: 99%

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Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts

et al. 2006

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Serologic studies are an important diagnostic tool in the clinical evaluation and follow-up of persons with coccidioidomycosis. Numerous types of serologic tests are available, including immunodiffusion, enzyme immunoassay, and complement fixation. We conducted a retrospective review of the results of 1,797 serologic tests spanning 12 months from the onset of coccidioidomycosis in 298 immunocompetent and 62 immunosuppressed persons with symptomatic infection. Using the onset of symptoms as a reference point, we plotted the positive or negative serologic results over time for both groups. Compared with the immunocompetent group, immunosuppressed persons had lower rates of seropositivity for every type of test during the first year after onset of symptoms for coccidioidomycosis, although many results did not achieve statistical significance. Combining the results of these tests increased the sensitivity of the serologic evaluation in immunocompromised patients. Immunosuppressed persons have the ability to mount a serologic response to coccidioidomycosis, but in some circumstances, multiple methods may be required to improve detection.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts

et al. 2006

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“…Aside from pregnancy, other risk factors for complicated coccidioidomycosis, with chronic pulmonary infection and dissemination, include chronic health conditions that impact T-cell function, such as human immunodeficiency virus (HIV) (particularly if the patient has a CD4 cell count <250 k/mL or an AIDS diagnosis) and cancer (especially Hodgkin disease), and immunosuppressive agents used for transplant recipients [ 1 , 9 ]. Additional risk factors for disseminated disease include the extremes of age, and African American, Hispanic or Filipino race [ 2 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of disseminated coccidioidomycosis in pregnancy through placental pathology: A case report

Lopez¹,

Cheung

Fassett

2022

Case Reports in Women's Health

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“…Geographically restricted endemic mycoses can be imitators of lung cancer [15]. Also, the epidemiologic data suggest that nontuberculous mycobacterial lung infections are occurring with increasing frequency in the United States and, likely, other parts of the world [16].…”

Section: Discussionmentioning

confidence: 99%

Open-lung biopsy in patients with undiagnosed lung lesions referred at a tertiary cancer center is safe and reveals noncancerous, noninfectious entities as the most common diagnoses

Georgiadou

Sampsonas

Rice

et al. 2012

Eur J Clin Microbiol Infect Dis

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We evaluated the diagnostic yield of open-lung biopsies (OLBs) in a large tertiary cancer center to determine the role of infectious diseases as causes of undiagnosed pulmonary lesions. All consecutive adult patients with either single or multiple pulmonary nodules or masses who underwent a diagnostic OLB over a period of 10 years (1998–2007) were retrospectively identified. Their risk factors for malignancy and clinical and radiological characteristics were reviewed, and their postoperative complications were assessed. We evaluated 155 patients with a median age of 57 years (range, 19–83 years). We identified infectious etiologies in 29 patients (19 %). The most common diagnosis in this group was histoplasmosis (12 [41 %]), followed by nontuberculous mycobacterial infection (7 [24 %]) and aspergillosis (4 [14 %]). The majority of the 126 remaining patients had nonmalignant diagnoses, the most prevalent being nonspecific granuloma (26 %), whereas only 17 % had malignant diagnoses. We observed no significant differences among the patients with infectious, malignant, or both noninfectious and nonmalignant final diagnoses regarding their demographic, laboratory, and clinical characteristics. Six percent of the patients had at least one post-OLB complication, and the post-OLB mortality rate was 1 %. OLB is a safe diagnostic procedure which frequently identifies a wide variety of infectious and inflammatory diseases.

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Endemic Mycoses in a Cancer Hospital

Cited by 25 publications

References 59 publications

Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts

Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts

Diagnosis of disseminated coccidioidomycosis in pregnancy through placental pathology: A case report

Open-lung biopsy in patients with undiagnosed lung lesions referred at a tertiary cancer center is safe and reveals noncancerous, noninfectious entities as the most common diagnoses

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