Endemic Mycoses and Cryptococcus in Solid Organ Transplant Recipients

Beaird, Omer E.; Nanayakkara, Deepa; Gaynor, P.J.; Schaenman, Joanna

doi:10.21926/obm.transplant.1903075

Cited by 3 publications

(2 citation statements)

References 74 publications

(201 reference statements)

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“…Risk factors include allograft rejection, positive serology at the time of transplant, African American race, and a history of Coccidioides infection [ 42 ]. In general populations, most patients experience asymptomatic seroconversion; the incidence of asymptomatic seroconversion in SOT recipients is not known [ 131 ]. Proper identification of coccidioidomycosis infection is important in LTR as immunosuppressed patients are at an increased risk of disseminated disease.…”

Section: Coccidiodiomycosesmentioning

confidence: 99%

Diagnosis and Treatment of Fungal Infections in Lung Transplant Recipients

2023

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Fungal infections are a significant source of morbidity in the lung transplant population via direct allograft damage and predisposing patients to the development of chronic lung allograft dysfunction. Prompt diagnosis and treatment are imperative to limit allograft damage. This review article discusses incidence, risk factors, and symptoms with a specific focus on diagnostic and treatment strategies in the lung transplant population for fungal infections caused by Aspergillus, Candida, Coccidioides, Histoplasma, Blastomyces, Scedosporium/Lomentospora, Fusarium, and Pneumocystis jirovecii. Evidence for the use of newer triazole and inhaled antifungals to treat isolated pulmonary fungal infections in lung transplant recipients is also discussed.

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Section: Coccidiodiomycosesmentioning

confidence: 99%

Diagnosis and Treatment of Fungal Infections in Lung Transplant Recipients

2023

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“…Cryptococcus is a fungus in the soil, bird droppings (especially pigeons), and decaying wood most often located geographically in the Northwestern United States and Vancouver Island in Canada [ 1 ]. The two species associated with infection via the inhalation of spores through the respiratory tract in humans are Cryptococcus neoformans and Cryptococcus gattii [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Cryptococcosis: A Diagnostic and Management Challenge Case Report

Cardoso,

Carroll

2024

Cureus

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Cryptococcosis is a fungal infection that may arise in immunocompromised or immunocompetent individuals. This case report seeks to demonstrate the difficulty in diagnosing and treating cryptococcosis based on clinical presentation and radiographic features as together, they mimic other pathological conditions. A 56-year-old female with cirrhosis presented with persistent abdominal pain, dyspnea, vomiting, and diarrhea and was diagnosed with pulmonary cryptococcosis after an initial diagnosis of bacterial pneumonia. With no improvement following antibiotic therapy for suspected bacterial pneumonia, additional imaging was performed with a confirmatory lung biopsy for pulmonary cryptococcosis. The patient initiated antifungal therapy with the anticipation of completing approximately 12 months with follow-up imaging to evaluate improvement. After the patient experienced adverse effects of antifungal therapy and did not achieve significant improvement or recovery in her condition, it was apparent that cryptococcal pneumonia presents both diagnostic and management challenges that must be further explored.

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Gender-inclusive language in public-facing labor and delivery webpages in the New York City tristate area: An observational study (Preprint)

Isaac,

Dawes,

Howell

et al. 2023

Preprint

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BACKGROUND Transgender and nonbinary individuals are increasingly becoming gestational parents, and hospital websites should reflect these trends. For prospective transgender parents, a hospital website is the only way patients can assess their safety from discrimination while receiving perinatal care. Cisnormativity enforced by communication gaps between medical institutions and transgender patients can and has caused delays in receiving urgent care during their pregnancy. OBJECTIVE The aim of this study was to evaluate the current prevalence of gender-inclusive terminology among labor and delivery services in the New York City tristate area. METHODS The labor and delivery webpages of 189 hospitals from New York, New Jersey, and Connecticut were examined for gender-inclusive language. “Fully inclusive” websites explicitly acknowledged Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, Asexual plus other gender and sexual oriented (LGBTQIA+) patients, “inclusive” websites did not use gendered terminology for patients, and “non-inclusive” websites used gendered terms at least once in the text reviewed. The hospitals’ webpages were further stratified by Healthcare Equality Index (HEI) scores and population classifications defined by the 2013 National Center for Health Statistics (NCHS) Urban-Rural classification given to the county that each hospital was located in. RESULTS Of the 300 hospital websites reviewed and only 189 websites met criteria for inclusion. Overall, only 6.3% (n = 12) of labor and delivery webpages were “inclusive” or “fully inclusive”. No geographic areas (P = .61) or HEI score (P = .81) were associated with inclusive or fully inclusive language. CONCLUSIONS Hospitals need to utilize inclusive language to help gender-nonconforming people identify hospitals where their existence and needs are acknowledged and thus feel more comfortable in their transition to parenthood.

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Endemic Mycoses and Cryptococcus in Solid Organ Transplant Recipients

Abstract: The endemic mycoses are an important cause of morbidity and mortality in transplant recipients. These fungal infections are notable for their dimorphic life cycle, specific geographic distributions,

Cited by 3 publications

References 74 publications

Diagnosis and Treatment of Fungal Infections in Lung Transplant Recipients

Diagnosis and Treatment of Fungal Infections in Lung Transplant Recipients

Pulmonary Cryptococcosis: A Diagnostic and Management Challenge Case Report

Gender-inclusive language in public-facing labor and delivery webpages in the New York City tristate area: An observational study (Preprint)

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