Endemic diphtheria in Ho Chi Minh City; Viet Nam: A matched case–control study to identify risk factors of incidence

Murakami, Hitoshi; Phương, Nguyễn Minh; Thang, Ho Vinh; Chau, Nguyen Vinh; Giao, Pham Ngoc; Tho, Nguyen Dac

doi:10.1016/j.vaccine.2010.09.088

Cited by 16 publications

(9 citation statements)

References 23 publications

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“…The search on the effectiveness and duration of protection yielded a total of 1453 reviews. After screening of titles and abstracts, 8 full-text articles 35,36,37,38,39,40,41,42 were assessed for eligibility of which 1 36 was included in the qualitative synthesis. None of the studies fulfilled the inclusion criteria and provided an effect estimate on the outcome of continued (>10 years) duration of protection conveyed by a specific schedule of diphtheria-containing vaccines, though the results of 1 study was included for descriptive analysis (see Figure 1).…”

Section: Effectiveness Datamentioning

confidence: 99%

Immunogenicity of Diphtheria Booster Vaccination in Adolescents With Inflammatory Bowel Disease

Dembiński

Krzesiek

Klincewicz

et al. 2020

Pediatric Infectious Disease Journal

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The aim of this prospective study was to assess the immunogenicity and safety of booster vaccine against diphtheria in children with inflammatory bowel disease on and without immunosuppression treatment. Immunoprotection was achieved in 93% of the children. No significant differences depending on the treatment used and no serious adverse events or flares of inflammatory bowel disease were observed.

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Section: Effectiveness Datamentioning

confidence: 99%

Immunogenicity of Diphtheria Booster Vaccination in Adolescents With Inflammatory Bowel Disease

Dembiński

Krzesiek

Klincewicz

et al. 2020

Pediatric Infectious Disease Journal

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“…Several studies have shown that low vaccination coverage, crowding and migration, or a combination of host, agent, and environmental factors, can influence the incidence of diphtheria 6, 7 . Other factors include nutritional status and parental behavior, personal hygiene of children 8 , density of house occupancy, humidity in the house, type of floor of the house and the source of transmission (contracting from other people), parents knowledge about diphtheria 9 , parent education level 10, 11 , child age, home lighting, and house ventilation 12 .…”

Section: Introductionmentioning

confidence: 99%

Risk factors for diphtheria outbreak in children aged 1-10 years in East Kalimantan Province, Indonesia

et al. 2018

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Background: Diphtheria remains a health problem, especially in developing countries. In November 2017, the Indonesian Ministry of Health stated that there was a diphtheria outbreak in Indonesia. East Kalimantan is one of the provinces that experienced this disease outbreak. This study analyzes the risk factors for diphtheria outbreak in children aged 1-10 years. Methods: A case-control study was conducted on 37 respondents. Research variables consist of immunization status against diphtheria, pertussis and tetanus (DPT), nutritional status, children mobility, source of transmission, physical home environment (natural lighting, ventilation area, occupancy density, wall and floor type), knowledge of diphtheria and attitudes towards the diphtheria prevention program. Results: We found that the most of the children who had diphtheria had been immunized against DPT. Additionally the nutritional status of children (p=0.049), mobility (p=0.000) and the source of transmission (p=0.020) were significantly associated with diphtheria. Conclusions: Child/parent mobility (OR=8.456) is the main risk factor for diphtheria outbreak. It is recommended to limit the mobility of children to travel to areas that are experiencing increased cases of diphtheria, improve the nutritional status, and further research on the effectiveness of diphtheria vaccine.

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“…6 Several studies have shown that low vaccination coverage, crowding, migration, or a combination of host, agent, and environmental factors, can influence the incidence of diphtheria, 7,8 in addition to nutritional status, parental behavior, and personal hygiene of children. 9 Many outbreaks of diphtheria have been reported in various states of India in recent times. [10][11][12][13][14] A diphtheria outbreak of 593 cases in Indonesia was documented by several provincial health offices between 1 January and 1 November 2017, many occurring in East Kalimantan in children aged 1-10 years.…”

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confidence: 99%

Clinical spectrum and outcomes of pediatric diphtheria

Nawing

Pelupessy

Alimadong

et al. 2019

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Background Although vaccination programs have succeeded in reducing the incidence of diphtheria, it remains a health problem in Asia, including Indonesia. Objective To investigate the clinical spectrum and outcomes of pediatric diphtheria in Wahidin Sudirohusodo Hospital. Methods This study was a retrospective review of childhood diphtheria medical records from January 2011 to December 2017 in Wahidin Sudirohusodo Hospital, Makassar, South Sulawesi. Recorded data consisted of age, gender, nutritional and immunization statuses, signs and symptoms, throat swab culture results, complications, and outcomes. Results Of 28 subjects aged 9 months to 17.10 years, the majority were >5 years (57.1%) and male (60.7%). Subjects’ mean age was 6.15 years and 82.1% of cases were well nourished. Overall, 85.7% had received complete immunizations, while 14.3% were not immunized, having received neither basic nor booster vaccines. The presenting manifestations were fever, pseudomembranes, and sore throat in all subjects, enlarged tonsils (78.57%), dysphagia (67.86%), cough (57.14%), headache (57.14%), hoarseness (67.86%), bull neck (25%), and myocarditis (14.3%). Most subjects had hospital stays of >10 days (67.9%). Mortality was 14.3%, usually in those admitted with a late, deteriorating condition and dying before getting optimal treatment. Poor outcome was significantly associated with the lack of basic or booster immunizations, poor nourishment, bull neck, myocarditis, and hospital stays < 5 days (P<0.05 for all). Conclusion The clinical spectrum and outcomes of pediatric diphtheria in this study are relatively similar to reports from other hospitals. Mortality was mostly in patients who lack basic or booster immunizations, are poorly nourished, or have bull neck, myocarditis, or hospital stays < 5 days.

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Endemic diphtheria in Ho Chi Minh City; Viet Nam: A matched case–control study to identify risk factors of incidence

Cited by 16 publications

References 23 publications

Immunogenicity of Diphtheria Booster Vaccination in Adolescents With Inflammatory Bowel Disease

Immunogenicity of Diphtheria Booster Vaccination in Adolescents With Inflammatory Bowel Disease

Risk factors for diphtheria outbreak in children aged 1-10 years in East Kalimantan Province, Indonesia

Clinical spectrum and outcomes of pediatric diphtheria

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