Abstract:The concept of end-to-side nerve repair was recently introduced; however, most authors have reported conflicting results with this technique. This study was conducted to assess the effectiveness of end-to-side nerve repair in both fresh and predegenerated specimens by histological evaluation in an animal study in rabbits. Thirty male rabbits were divided into three groups. In group 1 (n = 14), the peroneal nerve was divided and sutured end-to-side to the tibial nerve via an epineurial window. In group 2 (n = 1… Show more
“…Electrophysiological investigations and functional tests indicated successful reinnervation of the forearm flexors and recovery of the flexor function. Despite these exciting results, Jaberi et al 11 showed that the average nerve fiber count in implanted peroneal nerves was 6 per cross-section, far less than the average of 532 per cross-section in normal peroneal nerves. Our results from both electrophysiology and nerve tissue analysis showed that the distal musculocutaneous nerve contained significantly more regenerated axons after end-to-side coaptation than in the transected nerve 5 months after repair.…”
“…Electrophysiological investigations and functional tests indicated successful reinnervation of the forearm flexors and recovery of the flexor function. Despite these exciting results, Jaberi et al 11 showed that the average nerve fiber count in implanted peroneal nerves was 6 per cross-section, far less than the average of 532 per cross-section in normal peroneal nerves. Our results from both electrophysiology and nerve tissue analysis showed that the distal musculocutaneous nerve contained significantly more regenerated axons after end-to-side coaptation than in the transected nerve 5 months after repair.…”
“…Recently, many authors have reported conflicting results with this end‐to‐side technique. Jaberi et al 6 assessed the effectiveness of end‐to‐side nerve repair in both fresh and predegenerated specimens by histologic evaluation in an animal study in rabbits. Their results suggested that collateral sprouting of donor nerves is possible after end‐to‐side neurorrhaphy through an epineurial window, but the number of nerve fibers in recipient nerves is too low to result in any functional recovery in the target organ.…”
“…However, there have been many experimental and clinical studies with conflicting results. Some authors suggested end-to-side coaptation as an alternative method in nerve repair, whereas others reported limited motor and sensory recovery [5][6][7][8].…”
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