Encapsulation of α-cyano-4-hydroxycinnamic acid into a NaY zeolite

Vilaça, Natália; Amorim, Ricardo; Martinho, Olga; Reis, Rui Manuel; Baltazar, Fátima; Fonseca, A.; Neves, Isabel C.

doi:10.1007/s10853-011-5722-2

Cited by 35 publications

(28 citation statements)

References 22 publications

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“…Due to the well-defined pore structure and pore topology, zeolites are widely used for adsorption, catalysis and separations [10]. The use of zeolites in drug delivery [7,8,[11][12][13][14][15][16], adsorption of pharmaceuticals [17] and imaging [18][19][20][21][22][23] has been explored in the literature. Specifically, the loading and release of drugs, such as sulfonamide antibiotics [11,24], ibuprofen [14], doxorubicin [13], and mitoxantrone [16] in zeolites have been investigated.…”

Section: Introductionmentioning

confidence: 99%

Loading and release of 5-fluorouracil from HY zeolites with varying SiO2/Al2O3 ratios

Datt

Burns

Dhuna

et al. 2013

Microporous and Mesoporous Materials

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Section: Introductionmentioning

confidence: 99%

Loading and release of 5-fluorouracil from HY zeolites with varying SiO2/Al2O3 ratios

Datt

Burns

Dhuna

et al. 2013

Microporous and Mesoporous Materials

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“…Special attention must be given to the properties of the nanoparticle-doped photopolymer in order to ensure that a spatial redistribution of the nanodopant takes place as result of the recording process. The redistribution of zeolite nanoparticles has been previously confirmed by Raman spectroscopy [59][60][61]. When illuminated at the appropriate angle by one beam the hologram produces a second diffracted beam.…”

Section: Holographic Sensor Based On Transmission Holographic Gratingmentioning

confidence: 75%

“…Moreover, based on the results obtained in various tumor cells and in tumor bearing animals, the zeolites have shown that they can be successfully applied as adjuvants in anticancer therapy. Anticancer drugs have been loaded into the pores of zeolite and have shown a noticeable cytotoxic effect when applied to cancer cells [61,62]. In these works, zeolite Y (FAU), zeolite A (LTA) [61] and zeolite Beta (BEA) [62] were used as hosts for releasing the anticancer drug.…”

Section: Zeolite For Antimicrobial and Medical Applicationsmentioning

confidence: 99%

“…Anticancer drugs have been loaded into the pores of zeolite and have shown a noticeable cytotoxic effect when applied to cancer cells [61,62]. In these works, zeolite Y (FAU), zeolite A (LTA) [61] and zeolite Beta (BEA) [62] were used as hosts for releasing the anticancer drug. Results showed that zeolites alone reveal no toxicity to cancer cells, while, importantly, anticancer drug-zeolite led to an inhibition of cell viability up to 585-fold when compared to the non-encapsulated drug.…”

Section: Zeolite For Antimicrobial and Medical Applicationsmentioning

confidence: 99%

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Progress in zeolite synthesis promotes advanced applications

Zaarour

Dong

Naydenova³

et al. 2014

Microporous and Mesoporous Materials

156

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a b s t r a c tThis article outlines the importance of zeolite synthesis and their unique physicochemical characteristics promoting advanced applications. The main strategies for preparation of zeolites including organic-template assisted, organic-template free and alternative procedures are considered for synthesis of crystallites offering control and fine-tuning of their properties. Besides, rational design of zeolites with pre-determined structure, porosity, size, morphology, and composition are more viable by studying carefully the chemical and physical parameters controlling the zeolite synthesis and understanding the crystallization mechanism. Finally, a particular attention to the preparation of zeolites with nanosized dimensions and their utilization in innovative applications including photovoltaic, medicine and holographic sensors are presented.

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“…[13][14][15] In our group we have already lead a 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 efficacy against colorectal carcinoma cells. [16][17][18] In the present study, SA was loaded by diffusion in liquid phase in the void space of three different porous structures: one micro (NaY) and two mesoporous (MCM-41 and SBA-15) structures. Zeolite Y has a Faujasite (FAU)-type structure and is a crystalline microporous aluminosilicate based on sodalite cages joined by O bridges between the hexagonal faces which are arranged in a three dimensional network.…”

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confidence: 97%

Micro- and Mesoporous Structures as Drug Delivery Carriers for Salicylic Acid

et al. 2015

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The potential of salicylic acid (SA) encapsulated in porous materials as drug delivery carriers for cancer treatment was studied. Different porous structures, the microporous zeolite NaY and the mesoporous SBA-15 and MCM-41 were used as hosts for the anti-inflammatory drug. Characterization with different techniques (FTIR, UV/vis, TGA, 1 H NMR and 13 C CPMAS NMR) demonstrated the successful loading of SA into the porous hosts. The mesoporous structures showed to be very efficient to encapsulate the SA molecule. The obtained drug delivery systems (DDS) accommodated 0.74 mmol (341 mg/g ZEO ) in NaY and 1.07 mmol (493 mg/g ZEO ) to 1.23 mmol (566 mg/g ZEO ) for SBA-15 and MCM-41, respectively. Interactions between SA molecules and pore structures were identified. A fast and unrestricted liberation of SA at 10 min of the dissolution assay was achieved with 29.3, 46.6 and 50.1 µg/mL of SA from NaY, SBA-15 and MCM-41, respectively, in the in vitro drug release studies (PBS buffer pH 7.4, 37 ºC). Kinetic modeling was used to determine the release patterns of the DDS. The porous structures and DDS were evaluated on Hs578T and MDA-MB-468 breast cancer cell lines viability. The porous structures are non-toxic to cancer cells. Cell viability reduction was only observed after the release of SA from MCM-41 followed by SBA-15 in both breast cancer cell lines.

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Encapsulation of α-cyano-4-hydroxycinnamic acid into a NaY zeolite

Cited by 35 publications

References 22 publications

Loading and release of 5-fluorouracil from HY zeolites with varying SiO2/Al2O3 ratios

Loading and release of 5-fluorouracil from HY zeolites with varying SiO2/Al2O3 ratios

Progress in zeolite synthesis promotes advanced applications

Micro- and Mesoporous Structures as Drug Delivery Carriers for Salicylic Acid

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