Micro- and Mesoporous Structures as Drug Delivery Carriers for Salicylic Acid

Abstract

The potential of salicylic acid (SA) encapsulated in porous materials as drug delivery carriers for cancer treatment was studied. Different porous structures, the microporous zeolite NaY and the mesoporous SBA-15 and MCM-41 were used as hosts for the anti-inflammatory drug. Characterization with different techniques (FTIR, UV/vis, TGA, 1 H NMR and 13 C CPMAS NMR) demonstrated the successful loading of SA into the porous hosts. The mesoporous structures showed to be very efficient to encapsulate the SA molecule. The obtained drug delivery systems (DDS) accommodated 0.74 mmol (341 mg/g ZEO ) in NaY and 1.07 mmol (493 mg/g ZEO ) to 1.23 mmol (566 mg/g ZEO ) for SBA-15 and MCM-41, respectively. Interactions between SA molecules and pore structures were identified. A fast and unrestricted liberation of SA at 10 min of the dissolution assay was achieved with 29.3, 46.6 and 50.1 µg/mL of SA from NaY, SBA-15 and MCM-41, respectively, in the in vitro drug release studies (PBS buffer pH 7.4, 37 ºC). Kinetic modeling was used to determine the release patterns of the DDS. The porous structures and DDS were evaluated on Hs578T and MDA-MB-468 breast cancer cell lines viability. The porous structures are non-toxic to cancer cells. Cell viability reduction was only observed after the release of SA from MCM-41 followed by SBA-15 in both breast cancer cell lines.

Exploring the Use of Amine Modified Mesoporous Magnesium Carbonate for the Delivery of Salicylic Acid in Topical Formulations: In Vitro Cytotoxicity and Drug Release Studies

“…Different carrier materials have been used for both topological and systemic administration of SA, for example, it has been loaded into the polymer backbone in biodegradable polymers (e.g., cross-linked polyester based on xylitol and adipic acid) for a sustained release of SA [10]. SA has also been loaded into different porous matrices, in MCM-41 and SBA-15 [11] and also in halloysite nanotubes functionalized with dendrimers [12].…”

Mono and bimetallic NaY catalysts with high performance in nitrate reduction in water

“…These crystalline aluminosilicate porous materials with very large surface areas were applied in different areas such as cation-exchangers, adsorbents, heterogeneous catalysts, biosorption supports, drug delivery carriers and also attract interest in materials science for the development of functional materials and in nanotechnology [17,18]. Recently, the use of the natural zeolite in biological reactors including the up flow anaerobic sludge blanket (UASB) [19] and as a support for zero valent metals have been reported for nitrate removal with a natural zeolite [20].…”

Understanding the Incorporation and Release of Salicylic Acid in Metal‐Organic Frameworks for Topical Administration

“…After 24 h, the total amount of released drug is 66.8 % (or 103.3 mg of SA per g of UiO‐66, Supporting information, Figure S5). The release profile and the time to reach the plateau in play here is similar when further compared to previously delivery studies of SA in water ( e. g ., 60 % in 10 h from halloysite nanotubes; [53] 50 % in 15 min from the microporous zeolite NaY, and the mesoporous SBA‐15 and MCM‐41) [54] …”

“…The release profile and the time to reach the plateau in play here is similar when further compared to previously delivery studies of SA in water (e. g., 60 % in 10 h from halloysite nanotubes; [53] 50 % in 15 min from the microporous zeolite NaY, and the mesoporous SBA-15 and MCM-41). [54] The desorption data can be satisfactorily fitted to a first order kinetic model according to Equation (1):…”