Encapsulation of water-soluble drugs in Poly (vinyl alcohol) (PVA)- microparticles via membrane emulsification: Influence of process and formulation parameters on structural and functional properties

Piacentini, Emma; Bazzarelli, Fabio; Poerio, Teresa; Albisa, Airama; Irusta, Silvia; Mendoza, Gracia; Sebastián, Víctor; Giorno, Lidietta

doi:10.1016/j.mtcomm.2020.100967

Cited by 18 publications

(11 citation statements)

References 37 publications

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“…Compared with commercial microspheres, these nanoparticles showed better controlled-release properties, UV resistance, storage stability, leaf surface coverage, and bacteriostatic effect. Piacentini et al 124 studied the influence of membrane emulsification (membrane and homogenizing approaches), phase composition, poly(vinyl alcohol) concentration, drug concentration, physicochemical properties of the drug, and cross-linking reaction conditions (cross-linking reagent concentration and acidic media) on the structural and functional properties. They prepared poly(vinyl alcohol) microparticles by membrane emulsification and chemical crosslinking.…”

Section: Nanotechnology In the Preparation Of Controlled-release Form...mentioning

confidence: 99%

Advances in Controlled-Release Pesticide Formulations with Improved Efficacy and Targetability

Sun

Jiang

et al. 2021

J. Agric. Food Chem.

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Pesticides are commonly used in modern agriculture and are important for global food security. However, postapplication losses due to degradation, photolysis, evaporation, leaching, surface runoff, and other processes may substantially reduce their efficacy. Controlled-release formulations can achieve the permeation-regulated transfer of an active ingredient from a reservoir to a target surface. Thus, they can maintain an active ingredient at a predetermined concentration for a specified period. This can reduce degradation and dissipation and other losses and has the potential to improve efficacy. Recent developments in controlled-release technology have adapted the concepts of intelligence and precision from the pharmaceutical industry. In this review, we present recent advances in the development of controlled-release formulations and discuss details of the preparation methods, material improvements, and application technologies.

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Section: Nanotechnology In the Preparation Of Controlled-release Form...mentioning

confidence: 99%

Advances in Controlled-Release Pesticide Formulations with Improved Efficacy and Targetability

Sun

Jiang

et al. 2021

J. Agric. Food Chem.

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“…Additionally, CC-α-T particles maintained a spherical shape and a smooth surface after the solidification step during solvent diffusion/evaporation ( Figure 6 A,B). Solidified CH+α-T particles were successfully produced by combining membrane emulsification and the cross-linking reaction as demonstrated in previous work ( Figure 6 C) [ 21 , 22 , 23 , 24 , 25 ].…”

Section: Resultsmentioning

confidence: 88%

Production of α-Tocopherol–Chitosan Nanoparticles by Membrane Emulsification

et al. 2022

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α-tocopherol (α-T) has the highest biological activity with respect to the other components of vitamin E; however, conventional formulations of tocopherol often fail to provide satisfactory bioavailability due to its hydrophobic characteristics. In this work, α-tocopherol-loaded nanoparticles based on chitosan were produced by membrane emulsification (ME). A new derivative was obtained by the cross-linking reaction between α-T and chitosan (CH) to preserve its biological activity. ME was selected as a method for nanoparticle production because it is recognized as an innovative and sustainable technology for its uniform-particle production with tuned sizes and high encapsulation efficiency (EE%), and its ability to preserve the functional properties of bioactive ingredients operating in mild conditions. The reaction intermediates and the final product were characterized by 1HNMR, Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC), while the morphological and dimensional properties of the nanoparticles were analyzed using electronic scanning microscopy (SEM) and dynamic light scattering (DLS). The results demonstrated that ME has high potential for the development of α-tocopherol-loaded nanoparticles with a high degree of uniformity (PDI lower than 0.2), an EE of almost 100% and good mechanical strength, resulting in good candidates for the production of functional nanostructured materials for drug delivery. In addition, the chemical bonding between chitosan and α-tocopherol allowed the preservation of the antioxidant properties of the bioactive molecule, as demonstrated by an enhanced antioxidant property and evaluated through in vitro tests, with respect to the starting materials.

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“…Polyvinyl alcohol (PVA) is one of the most easily electrospinable polymers that offers unique characteristics such as excellent gel-forming properties and good film-matrix forming ability. Thus, PVA had been widely exploited for drug delivery and enzyme encapsulation [30][31][32][33][34]. Additionally, PVA is also known for its high biocompatibility and hydrophilicity, ease of processing, non-toxic, and biodegradable nature, confirming its ability to work as a matrix in immobilizing and stabilizing enzymes [35,36].…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous Membrane with Encapsulated Glucose Oxidase for Self-Sustained Antimicrobial Applications

Leonarta

Lee

2021

Membranes

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Polyvinyl alcohol (PVA) nanofibrous membrane, consisting of separately encapsulated glucose oxidase (GOx) and glucose (Glu) nanofibers, was prepared via simultaneously electrospinning PVA/GOx and PVA/Glu dopes. The as-prepared pristine membrane could self-sustainably generate hydrogen peroxide (H2O2) only in contact with an aqueous solution. The H2O2 production level was well maintained even after storing the dry membrane at room temperature for 7 days. Cross-linking the membrane via reaction with glutaraldehyde (GA) vapor could not only prevent the nanofibrous membrane from dissolving in water but also prolonged the release of H2O2. The sustained release of H2O2 from the membrane achieved antimicrobial capability equivalent to that of 1% H2O2 against both Escherichia coli and Staphylococcus aureus. Gram(+) S. aureus cells were more susceptible to H2O2 than Gram(−) E. coli and >99% of S. aureus were killed after 1 h incubation with the membrane. Pristine and GA-crosslinked nanofibrous membrane with in situ production of H2O2 were self-sterilized in which no microorganism contamination on the membrane could be detected after 2 weeks incubation on an agar plate. The GOx/Glu membrane may find potential application as versatile antimicrobial materials in the field of biomedicine, in the food and health industries, and especially challenges related to wound healing in diabetic patients.

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Encapsulation of water-soluble drugs in Poly (vinyl alcohol) (PVA)- microparticles via membrane emulsification: Influence of process and formulation parameters on structural and functional properties

Cited by 18 publications

References 37 publications

Advances in Controlled-Release Pesticide Formulations with Improved Efficacy and Targetability

Advances in Controlled-Release Pesticide Formulations with Improved Efficacy and Targetability

Production of α-Tocopherol–Chitosan Nanoparticles by Membrane Emulsification

Nanofibrous Membrane with Encapsulated Glucose Oxidase for Self-Sustained Antimicrobial Applications

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