Encapsulation of ultrasmall nanophosphors into liposomes by thin-film hydration

Chang, Qing; Fan, Jiahui; Cheng, Li; Liu, Chenghao; Shu, Qingfeng; Deng, Xiaoyong; Su, Qianqian

doi:10.1140/epjs/s11734-021-00385-6

Cited by 2 publications

(1 citation statement)

References 37 publications

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“…Based on the standard MRPs solution curve, the initial concentration of MRPs in the MRPL was calculated after adding 10% (v/v) Triton X-100 to break the membrane [19]. After different treatments, the solutions were centrifugated at 45,000 rpm for 30 min at 4 • C using a Sorvall MTX 150 ultracentrifuge (Thermo Fisher Scientific Inc., Waltham, MA, USA) to collected MRPL precipitate [16].…”

Section: Degradation Ratementioning

confidence: 99%

Monascus Red Pigment Liposomes: Microstructural Characteristics, Stability, and Anticancer Activity

Peng

Zhu

Lai

et al. 2023

Foods

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Monascus red pigments (MRPs), which are a kind of natural colorant produced by Monascus spp., are widely used in the food and health supplements industry but are not very stable during processing and storage. Thus, MRPs were embedded into liposome membranes using a thin-film ultrasonic method to improve stability in this study. Monascus red pigments liposomes (MRPL) exhibited spherical unilamellar vesicles (UV) with particle size, polydispersity indexes (PDI), and zeta potential of 20–200 nm, 0.362 ± 0.023, and −42.37 ± 0.21 mV, respectively. pH, thermal, light, metal ion, storage, and in vitro simulated gastrointestinal digestion stability revealed that, compared with free MRPs, liposomes embedding significantly enhanced the stability of MRPs when exposed to adverse environmental conditions. Furthermore, anticancer assay suggested that MRPL exhibited a stronger inhibitory effect on MKN-28 cells by damaging the integrity of cells, with the IC50 value at 0.57 mg/mL. Overall, MRPLs possess stronger stability in external environment and in vitro simulated digestion with greater anticancer activity, indicating that MRPLs have the potential for promising application in the functional foods and pharmaceutical industries.

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Section: Degradation Ratementioning

confidence: 99%