Encapsulation of thiabendazole in hydroxypropyl‐β‐cyclodextrin nanofibers via polymer‐free electrospinning and its characterization

Abstract

BACKGROUNDThiabendazole (TBZ) is a poorly water‐soluble benzimidazole fungicide. However, the water solubility of TBZ can be significantly enhanced by inclusion complexation with cyclodextrins. In this study, a thiabendazole/hydroxypropyl‐β‐cyclodextrin (TBZ/HPβCD) complex was synthesized and electrospinning was performed to produce a TBZ/HPβCD nanofibrous (TBZ/HPβCD‐NF) complex that improved water solubility and antifungal activity.RESULTSThe formation of TBZ/HPβCD‐NF was characterized by Fourier transform infrared spectroscopy, X‐ray diffraction and nuclear magnetic resonance. The morphology of TBZ/HPβCD‐NF was studied by scanning electron microscopy. A phase solubility experiment showed that HPβCD exerted a great solubilization effect on TBZ, and TBZ/HPβCD‐NF had better antifungal activity compared to that of TBZ alone.CONCLUSIONSIn summary, the solid fungicidal nanodispersion prepared in the present study is a new type of formulation that can enhance the water solubility of TBZ. This formulation, which demonstrated potential as a new fast dissolving formulation type with increased efficacy, is expected to be conducive to the sustainable development of agriculture. © 2020 Society of Chemical Industry

Fragments recombination, design, synthesis, safener activity and CoMFA model of novel substituted dichloroacetylphenyl sulfonamide derivatives

“…The crystal structure of Zea mays HPPD was downloaded from the Protein Data Bank (PDB ID: 1SP8) 48,49 . Docking modeling used the CDOCKER method in Discovery Studio 3.5 (BIOVIA, San Diego, CA, USA) 50,51 . Water and some other co‐crystallized small molecules were eliminated at first.…”

“…48,49 Docking modeling used the CDOCKER method in Discovery Studio 3.5 (BIOVIA, San Diego, CA, USA). 50,51 Water and some other co-crystallized small molecules were eliminated at first. The CHARMM force (general-purpose all-atom force fields with a wide coverage for proteins, nucleic acids and general organic molecules) field was used to obtain the protein structure.…”

Protective efficacy of phenoxyacetyl oxazolidine derivatives as safeners against nicosulfuron toxicity in maize

“…6,7 However, as it is heavily applied and potentially toxigenic, it may be phytotoxic to sensitive crops. [8][9][10] After 7-14 days nicosulfuron treatment, sensitive maize seedling varieties were severely damaged. 11 Nicosulfuron markedly altered lipids and the ascorbate-glutathione cycle and induced symptoms ranging from severe plant growth retardation to the death of the entire plant.…”

“…Nicosulfuron is a systemic SU that controls numerous annual and perennial grasses in maize fields 6,7 . However, as it is heavily applied and potentially toxigenic, it may be phytotoxic to sensitive crops 8–10 . After 7–14 days nicosulfuron treatment, sensitive maize seedling varieties were severely damaged 11 .…”

Herbicidal activity and molecular docking study of novel PPO inhibitors

“…Moreover, substructure splicing is a widely used method in the discovery of new drugs. In the development of pesticides, many potential lead compounds are designed based on this method (Gao et al 2020;Ye et al 2019aYe et al , 2019bZhang et al 2020a). These findings have inspired us to introduce tetrahydrophthalimide structures into diphenyl ether herbicides, which could lead to the discovery of new herbicides with high activity, enhanced safety, and low residue levels ( Figure 3).…”