Encapsulation of the natural antioxidant aureusidin in biodegradable PLA nanoparticles

Roussaki, Marina; Gaitanarou, A.; Diamanti, P.Ch.; Vouyiouka, Stamatina; Papaspyrides, Constantine; Kefalas, Panagiotis; Detsi, Anastasia

doi:10.1016/j.polymdegradstab.2014.08.004

Cited by 44 publications

(26 citation statements)

References 34 publications

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“…Furthermore, in all cases the PDI values obtained were low enough to be considered satisfactory, being even lower than those obtained by other authors in the preparation of similar PLA nanoparticles (Roussaki et al, 2014;Wrona et al, 2017). As regards Figure 1B, the thymol recovered from the nanoparticles followed a similar trend to the average size, in that increasing the concentration of PLA and thymol led to an increase in the amount of thymol recovered.…”

Section: Size Polydispersity Index Thymol Recovered and Encapsulaticontrasting

confidence: 50%

Production and characterisation of biodegradable PLA nanoparticles loaded with thymol to improve its antimicrobial effect

Marcet

Weng

Sáez‐Orviz

et al. 2018

Journal of Food Engineering

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Section: Size Polydispersity Index Thymol Recovered and Encapsulaticontrasting

confidence: 50%

Production and characterisation of biodegradable PLA nanoparticles loaded with thymol to improve its antimicrobial effect

Marcet

Weng

Sáez‐Orviz

et al. 2018

Journal of Food Engineering

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“…The PDI is a measure of the uniformity of the ICs’ sizes, constituting a significant indicator concerning the uniformity of the attributes that the ICs present (i.e., ICs of uniform sizes bring similarly loads of the bioactive agent, which leads to a uniform release of it.). As far as the ζ-potential is concerned, it constitutes an indicator of the ICs’ stability in suspension [ 30 ]. As the absolute value of the ζ-potential increases, the greater the repulsive forces between them, reducing their tendency to aggregate; therefore, the more stable the ICs become.…”

Section: Resultsmentioning

confidence: 99%

Encapsulation of Oregano (Origanum onites L.) Essential Oil in β-Cyclodextrin (β-CD): Synthesis and Characterization of the Inclusion Complexes

et al. 2017

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The aim of the present work was to study the encapsulation of Origanum onites L. essential oil (oregano EO) in β-cyclodextrin (β-CD) inclusion complexes (ICs), using the co-precipitation method. The formed β-CD–oregano EO ICs were characterized by diverse methods, such as Dynamic Light Scattering (DLS), FT-IR spectroscopy, Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Nuclear Magnetic Resonance (NMR) spectroscopy and Scanning Electron Microscopy (SEM). UV-Vis spectroscopy was used for the determination of the inclusion efficacy and the study of the encapsulated oregano EO release profile. The interactions between host (β-CD) and guest (oregano EO) in the formed ICs were proven by the FT-IR, DSC, TG and NMR analyses. The ICs, which derived from different batches, presented nanoscale size (531.8 ± 7.7 nm and 450.3 ± 11.5 nm, respectively), good size dispersion (0.308 ± 0.062 and 0.484 ± 0.029, respectively) and satisfactory stability in suspension (ζ-potential = −21.5 ± 1.2 mV and −30.7 ± 1.8 mV). Inclusion efficiency reached up to 26%, whereas the oregano EO release from the ICs followed a continuous delivery profile for up to 11 days, based on in vitro experiments. The formed ICs can find diverse applications, such as in the preparation of films for active packaging of food products, in personal care products for the improvement of their properties (e.g., antioxidant, antimicrobial, etc.), as well as in insect repellent products.

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“…Roussaki et al [80] investigated the nanoencapsulation of a naturally-occurring antioxidant, aureusidin, in PLA NPs. The NPs were prepared by an emulsification-solvent evaporation technique in the presence of various amounts of aureusidin (20% and 60%) and particles of between 231-376 nm in size were obtained.…”

Section: Poly-dl-lactide-based Nanoparticlesmentioning

confidence: 99%

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

et al. 2019

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Antioxidants interact with free radicals, terminating the adverse chain reactions and converting them to harmless products. Antioxidants thus minimize the oxidative stress and play a crucial role in the treatment of free radicals-induced diseases. However, the effectiveness of natural and/or synthetic antioxidants is limited due to their poor absorption, difficulties to cross the cell membranes, and degradation during delivery, hence contributing to their limited bioavailability. To address these issues, antioxidants covalently linked with nanoparticles, entrapped in nanogel, hollow particles, or encapsulated into nanoparticles of diverse origin have been used to provide better stability, gradual and sustained release, biocompatibility, and targeted delivery of the antioxidants with superior antioxidant profiles. This review aims to critically evaluate the recent scientific evaluations of nanoparticles as the antioxidant delivery vehicles, as well as their contribution in efficient and enhanced antioxidant activities.

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Encapsulation of the natural antioxidant aureusidin in biodegradable PLA nanoparticles

Cited by 44 publications

References 34 publications

Production and characterisation of biodegradable PLA nanoparticles loaded with thymol to improve its antimicrobial effect

Production and characterisation of biodegradable PLA nanoparticles loaded with thymol to improve its antimicrobial effect

Encapsulation of Oregano (Origanum onites L.) Essential Oil in β-Cyclodextrin (β-CD): Synthesis and Characterization of the Inclusion Complexes

Nanoantioxidants: Recent Trends in Antioxidant Delivery Applications

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