Encapsulation of Oregano (Origanum onites L.) Essential Oil in β-Cyclodextrin (β-CD): Synthesis and Characterization of the Inclusion Complexes

Kotronia, Margarita; Kavetsou, Eleni; Loupassaki, Sofia; Kikionis, Stefanos; Vouyiouka, Stamatina; Detsi, Anastasia

doi:10.3390/bioengineering4030074

Cited by 71 publications

(51 citation statements)

References 44 publications

(99 reference statements)

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“…However, there are important limitations on the use of these essential oils in agriculture, resulting in reduced contact with pathogens, and they are susceptible to degradation upon exposure to ultraviolet radiation, high temperatures and oxidation by atmospheric oxygen . The encapsulation of essential oils could be an efficient way to overcome these problems . The present work showed the efficacy of a solid CD/1,8‐cineole inclusion complex against E. ceratoniae larvae and adults.…”

Section: Discussionmentioning

confidence: 99%

Post‐harvest management control of Ectomyelois ceratoniae (Zeller) (Lepidoptera: Pyralidae): new insights through essential oil encapsulation in cyclodextrin

Abada

Haouel-Hamdi

Gharib

et al. 2019

Pest Management Science

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BACKGROUND: Essential oils are reported to be bio-insecticides. However, problems related to their volatility, oxidation and poor water solubility need to be solved before they can be considered as replacement pest control methods. Thus, an appropriate formulation is needed for commercial use. In this work, a new control method based on the use of a powdered cyclodextrin (CD)/1,8-cineole inclusion complex was assessed against larvae and adults of Ectomyelois ceratoniae (Zeller) in comparison with two Rosmarinus officinalis (L.) essential oils, free 1,8-cineole (oils major compound) and a mixture of 50% CD/1,8-cineole inclusion complex and 50% free 1,8-cineole. −1 air, the respective mortalities were 94.12%, 35.29% and 19.61% for solid CD/1,8-cineole complex, Thala and Cap Zbib oils after 37 days of exposure. Moreover, the solid CD/1,8-cineole complex achieved 5% adult emergence versus 68.33% for Cap Zbib and 55% for Thala oils. The half-life of solid CD/1,8-cineole inclusion complex (10.98 days) was considerably longer than that of the mixture (7.53 days) or free 1,8-cineole (3.43 days). CONCLUSION: This work highlights the utility of essential oil encapsulation in CD to overcome restrictions when used to control the date moth E. ceratoniae during storage. RESULTS: Solid CD/1,8-cineole complex was more toxic against E. ceratoniae larvae than the two crude essential oils. At a concentration of 15 L liter

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Section: Discussionmentioning

confidence: 99%

Post‐harvest management control of Ectomyelois ceratoniae (Zeller) (Lepidoptera: Pyralidae): new insights through essential oil encapsulation in cyclodextrin

Abada

Haouel-Hamdi

Gharib

et al. 2019

Pest Management Science

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“…Thus, CD possesses a cage-like supramolecular structure with a hydrophobic cavity and hydrophilic external; it is able to form inclusion complexes with a wide variety of hydrophobic guest molecules and consequently improves their solubility. The inclusion compound—CDs outside and the guest molecules inside—is similar to a molecular capsule and may have a slow-release effect [ 17 , 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of β-CD-Ellagic Acid Microspheres and Their Effects on HepG2 Cell Proliferation

et al. 2017

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Objective: In this study, β-cyclodextrin (β-CD) was chosen as the coating for ellagic acid to prepare ellagic acid microspheres, and the effect of microspheres on the growth of HepG2 cells was observed. Methods: Scanning electron microscopy, infrared spectroscopy, and release rate analysis were used to identify the formation of ellagic acid microspheres. Methyl thiazolyl tetrazolium (MTT) assay was used to detect the effect of different concentrations of ellagic acid microspheres on tumor cell proliferation at 6, 12, 24 and 36 h, and cell morphology and quantity were observed using hematoxylin-eosin (HE) staining. Single-cell gel electrophoresis was used to observe the effect of ellagic acid microspheres on the DNA damage of HepG2 cells, and the Olive tail moment and the mRNA expression of tumor suppressor protein gene p53 was measured. Results: β-CD could be used as wrapping material of ellagic acid to prepare ellagic acid microspheres. HepG2 cell proliferation could be inhibited by 0.1, 0.3 and 0.5 g/L of ellagic acid microspheres in a dose- and time-dependent manner, and the mechanism of proliferation inhibition was related to DNA damage and cell apoptosis. Conclusion: Preparing ellagic acid microspheres with β-CD is feasible, and ellagic acid microspheres have potential therapeutic value (anticancer).

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“…The TGA thermogram showed two degradation steps that belonged to thermolysis of the ester group with the subsequent evaporation of the carvacrol moiety and oxidation of the aminoacidic portion, respectively (Table 2). These events were detected in DSC (Figure 4c) in the form of large endothermic peaks at 224 • C with ∆H of −397.26 Jg −1 , 248 • C with ∆H of −433.06 Jg −1 , and 241 • C with ∆H = −465.11 Jg −1 for WSCP1, WSCP2, and WSCP3, respectively [47][48][49][50].…”

Section: Tga and Dscmentioning

confidence: 97%

Carvacrol Prodrugs with Antimicrobial Activity Loaded on Clay Nanocomposites

et al. 2020

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Background: Carvacrol, an essential oil with antimicrobial activity against a wide range of pathogens, and its water soluble carvacrol prodrugs (WSCP1-3) were intercalated into montmorillonite (VHS) interlayers to improve their stability in physiological media and promote their absorption in the intestine. Methods: Intercalation of prodrugs by cation exchange with montmorillonite interlayer counterions was verified by X-ray powder diffraction and confirmed by Fourier transform infrared spectroscopy and thermal analysis. Results: In vitro release studies demonstrated that montmorillonite successfully controlled the release of the adsorbed prodrugs and promoted their bioactivation only in the intestinal tract where carvacrol could develop its maximum antimicrobial activity. The amount of WSCP1, WSCP2, and WSCP3 released from VHS were 38%, 54%, and 45% at acid pH in 120 min, and 65%, 78%, and 44% at pH 6.8 in 240 min, respectively. Conclusions: The resultant hybrids successfully controlled conversion of the prodrugs to carvacrol, avoiding premature degradation of the drug.

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Encapsulation of Oregano (Origanum onites L.) Essential Oil in β-Cyclodextrin (β-CD): Synthesis and Characterization of the Inclusion Complexes

Cited by 71 publications

References 44 publications

Post‐harvest management control of Ectomyelois ceratoniae (Zeller) (Lepidoptera: Pyralidae): new insights through essential oil encapsulation in cyclodextrin

Post‐harvest management control of Ectomyelois ceratoniae (Zeller) (Lepidoptera: Pyralidae): new insights through essential oil encapsulation in cyclodextrin

Preparation of β-CD-Ellagic Acid Microspheres and Their Effects on HepG2 Cell Proliferation

Carvacrol Prodrugs with Antimicrobial Activity Loaded on Clay Nanocomposites

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