Encapsulation of the flavonoid quercetin with chitosan-coated nano-liposomes

Hao, Jianpeng; Guo, Bing; Yu, Shaoxuan; Zhang, Wentao; Zhang, Daohong; Wang, Jianlong; Wang, Yanru

doi:10.1016/j.lwt.2017.06.048

Cited by 155 publications

(72 citation statements)

References 30 publications

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“…Meanwhile, the PDI decreased from 0.36 to 0.12 from day 90 to 120, indicating more homogeneous distribution of AEL (Table ). Previous study also indicated that the particles aggregated to form small clusters first, and then come together into large agglomerates, and along with increased time, the liposomes particles might be broken down, resulting in the reduced particle size at last (Hao et al., ).…”

Section: Resultsmentioning

confidence: 95%

“…As shown in Table , there were no significant differences in terms of particle size and PDI for the AEL stored within 15 days, and the mean particle size and PDI varied, from 301.50 to 299.40 nm and from 0.34 to 0.33, respectively. At day 30, the mean particle size and PDI significantly increased ( P < 0.05), especially the PDI increasing to 0.37, which was caused by the agglomeration of the small particles (Hao et al., ). After 60 days, the mean particle size reduced significantly from 428.9 at day 60 to 157.80 nm at day 120 ( P < 0.05), probably due to the degradation of AEL.…”

Section: Resultsmentioning

confidence: 99%

“…In this study, the effective diameter of the blank liposomes and AEL was 189.40 and 301.50 nm, respectively (Figure S1 providing the detail information of AEL particles’ distributions). The PDI value of the blank liposomes and AEL was 0.33 and 0.34, respectively, indicating that the liposomes were polydisperse and in a good homogeneous population (Hao et al., ).…”

Section: Resultsmentioning

confidence: 99%

“…and from 0.34 to 0.33, respectively. At day 30, the mean particle size and PDI significantly increased (P < 0.05), especially the PDI increasing to 0.37, which was caused by the agglomeration of the small particles (Hao et al, 2017). After 60 days, the mean particle size reduced significantly from 428.9 at day 60 to 157.80 nm at day 120 (P < 0.05), probably due to the degradation of AEL.…”

Section: Food Engineering Materials Science and Nanotechnologymentioning

confidence: 92%

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Preparation, Optimization, and Characterization of Natural Apple Essence‐Loaded Liposomes

Sun

Deng

Zhao

2019

Journal of Food Science

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Natural apple essence has been utilized as a flavor enhancer in food and other products, but the aroma components are highly volatile, limiting its applications. In this study, apple essence‐loaded liposomes (AEL) were prepared by an ultrasonic thin‐film evaporation method to enhance the stability of apple essence. Response surface methodology was used to evaluate the effects of cholesterol to lecithin ratio, apple essence concentration, and ultrasonic power on apple essence entrapment quantity in liposomes. The optimum AEL formula was identified as 0.2% of lecithin, 0.1237 of cholesterol to lecithin (w/w) ratio, 8.3% of apple essence, and 77 W of ultrasonic power with resulting essence encapsulation efficiency of 51.5%. The optimized AEL was characterized on particle size, morphology, and stability. The spherical AEL particles had an average diameter of 301.5 nm and displayed stable size distribution at 4 °C within 120 days. This study demonstrated that liposomes had a bright prospect for microencapsulation and stabilization of apple essence, and the stabilized AEL might provide new application opportunities in food and other industries. Practical Application Natural apple essence is widely accepted as a flavor enhancer, but its application is restricted due to high volatility. Liposomes are delivery systems to encapsulate functional ingredients and to enhance their bioactivity and stability. Liposomes using lecithin and cholesterol as wall materials were prepared by ultrasonic thin‐film evaporation method and effectively encapsulated apple essence in the present study. The optimized apple essence‐loaded liposomes (AEL) possessed favorable dispersing property and storability, and might be used as a flavor enhancer or functional component for food and other products for improving organoleptic quality and increasing the value of the product.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Food Engineering Materials Science and Nanotechnologymentioning

confidence: 92%

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Preparation, Optimization, and Characterization of Natural Apple Essence‐Loaded Liposomes

Sun

Deng

Zhao

2019

Journal of Food Science

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“…The encapsulation efficiency (EE) of quercetin was conducted according to the method described in references [33,34]. The encapsulated and non-encapsulated portions of quercetin from the QTC suspensions were separated using a centrifugal device with centrifugation at 10,000 rpm for 30 min.…”

Section: Preparation and Characterization Of Qtcsmentioning

confidence: 99%

Layer-by-Layer Deposition of Hyaluronan and Quercetin-Loaded Chitosan Nanoparticles onto Titanium for Improving Blood Compatibility

Liu

Chen

et al. 2020

Coatings

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Surface modification is an effective way to improve the hemocompatibility of biomaterials. Quercetin has significant anticoagulation and antithrombotic effects, and thus it is a promising candidate agent for the surface modification of blood-contacting materials. In this study, quercetin was successfully encapsulated in tripolyphosphate–chitosan nanoparticles (TCs) based on the ionic gelation of chitosan with tripolyphosphate (TPP) anions. Then, hyaluronan acid (HA)/quercetin-loaded TPP–chitosan nanoparticle (QTCs) films, in addition to HA/TCs films, were prepared separately using an electrostatic layer-by-layer self-assembly technique. The encapsulation of quercetin in the chitosan nanoparticles was confirmed by UV spectra. The quercetin-loaded multilayer coatings were also successfully self-assembled, as confirmed by the UV spectra and contact angle measurements. Platelet adhesion experiments were carried out with platelet-enriched plasma so as to evaluate the blood compatibility of the different samples. There were many platelets on the surfaces of the glass and HA/TC-coated titanium, which were partially activated but not aggregated. Meanwhile, many more platelets were observed on the uncoated titanium surfaces, most of which developed pseudopodia. By contrast, the platelet adhesion and activation were reduced remarkably on the surface of the HA/QTC-coated titanium. These results showed that the multilayer coatings containing quercetin could act as potential biomaterials to improve the anticoagulation performance of blood-contacting materials.

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