Encapsulation of polyphenols in pH-responsive micelles self-assembled from octenyl-succinylated curdlan oligosaccharide and its effect on the gut microbiota

Grafting chlorogenic acid enhanced the antioxidant activity of curdlan oligosaccharides and modulated gut microbiota

“…The concentrations of SCFAs of each fermented group at the fermentation time of 24 h were determined as described in a previous study ( Li et al, 2022d ).…”

Structured soft particulate matters for delivery of bioactive compounds in foods and functioning in the colon

“…106 Curdlan was hydrolysed to form oligosaccharides that were further modified with hydrophobic octenyl succinic anhydride, and the formed amphiphilic molecule formed micelles with a diameter of 230 nm. 107 Micelles were used to dissolve curcumin, quercetin, or both, forming particles smaller than 150 nm according to dynamic light scattering and smaller than 50 nm according to transmission electron microscopy. The release of encapsulated polyphenols was limited during the SGD but was gradual during the SID.…”

“…During the simulated human faecal fermentation, the micelles alone facilitated the production of SCFAs, and the co-encapsulated polyphenols promoted the growth of Bifidobacterium and inhibited the growth of E. coli and Shigella spp. 107 The loading capacity of LBCs in micelles is dependent on the molecular characteristics of amphiphilic molecules. Shellac has distinct polar and non-polar regimes in its molecular structure, and the small dimension of shellac micelles (14 nm) leads to a loading capacity of less than 8%.…”

“…During the simulated human faecal fermentation, the micelles alone facilitated the production of SCFAs, and the co-encapsulated polyphenols promoted the growth of Bifidobacterium and inhibited the growth of E. coli and Shigella spp. 107…”

“…105 Whereas, addition of octenyl succinate on curdlan oligosaccharides provides numerous binding sites leading to a loading capacity of over 20% when co-encapsulating curcumin and quercetin. 107 With the relative small dimensions, surfactant micelles are suitable for delivering LBCs in transparent beverages.…”