Encapsulation of plumbagin using cyclodextrins to enhance plumbagin stability: computational simulation, preparation, characterization, and application

Sinlikhitkul, Nathasak; Toochinda, Pisanu; Lawtrakul, Luckhana; Kuropakornpong, Pranporn; Itharat, Arunporn

doi:10.1007/s10847-018-0870-5

Cited by 11 publications

(8 citation statements)

References 40 publications

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“…To ensure the effective protection of bioactive ingredients against damaging conditions, many encapsulation techniques such as spray drying, coacervation, liposomes, and cyclodextrin inclusion complexes, have been employed in the fields of food, pharmaceutical and cosmetics industries. [1][2][3][4][5][6][7] Spray drying, although a widely available, continuous, and rapid process of drying and encapsulation, [8] exhibits also some serious disadvantages such as high energy consumption [9] and undesirable physicochemical reactions that may occur causing thermo-oxidative degradation of the processed material. [10] Amylose molecular inclusion complexation is an alternative and promising method that can favorably compete with the other encapsulating techniques and enhance the stability of the product during storage and application.…”

Section: Introductionmentioning

confidence: 99%

Functional Characteristics and Physical Properties of Spray Dried Starch Inclusion Complexes with Drugs

et al. 2021

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Starch systems containing bioactive compounds (ibuprofen, acetylsalicylic acid, paracetamol, myristic acid) are produced in a pilot plant scale spray dryer. The obtained powders are characterized in terms of their physical properties namely moisture, solubility, bulk and tapped density, suspensibility, hygroscopicity, cohesiveness, flowability, and particle size. The effect of spray drying processing parameters and storage relative humidity on the physical properties of powders is investigated. Light microscopy and Confocal Laser Scanning Microscopy (CLSM) are used to characterize the morphology of the powders and assess possible interaction of amylose with the bioactive compounds. A multiple response optimization is performed to determine the optimal physical properties for achieving the ideal powder formulation that jointly satisfy the spray drying operating conditions. Results revealed that the physical properties of powders are mainly affected by the different operating conditions employed during spray drying. All samples displayed significant differences in their physical properties. Microscopic examination showed the presence of disrupted and intact starch granules, albeit swollen. The optimal processing parameters for the production of spray dried powders with more satisfactory physical properties are obtained at high inlet temperatures. Principal component analysis (PCA) and cluster analysis (CA) showed that there are strong positive correlations among the physical properties of the powders.

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Section: Introductionmentioning

confidence: 99%

Functional Characteristics and Physical Properties of Spray Dried Starch Inclusion Complexes with Drugs

et al. 2021

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“…Ethanol is generally used as a cosolvent for the inclusion complex preparation process to improve the encapsulation efficiency [21]. Hence, the effect of various concentrations of ethanol on the encapsulation efficiency of CDs was investigated.…”

Section: Solvent Effect On the Encapsulation Efficiency Of Nicotine/cds Inclusion Complexmentioning

confidence: 99%

Stability Enhancement and Skin Permeation Application of Nicotine by Forming Inclusion Complex with β-Cyclodextrin and Methyl-β-Cyclodextrin

et al. 2021

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Nicotine is widely used in pharmaceutical industries, especially for smoking cessation in the form of transdermal patches. Nicotine gel in the patches has limitations from nicotine instability and high volatility. Thus, a nicotine preservation technique is needed. In this study, a nicotine encapsulation process using methyl-β-cyclodextrin (MβCD) is investigated and compared with β-cyclodextrin (βCD) to evaluate the preservation and skin permeation of nicotine. The M06-2X/6-31G(d,p) density functional theory calculations indicate a 1:1 host–guest molar ratio for the inclusion complex of nicotine with βCD and MβCD, which have been validated by experimental studies. The encapsulation efficiencies of βCD and MβCD to encapsulate nicotine are 59.96% and 63.76%, respectively. The preservation study of the inclusion complexes compared to pure nicotine shows a stability improvement of nicotine after being encapsulated. After 21 days, the percentages of the nicotine/βCD and nicotine/MβCD inclusion complexes that remain are 89.32% and 76.22%, while only 65.56% of pure nicotine remains. Besides the one-hour skin permeation tests, the amounts of nicotine permeated through pig skin from the nicotine/βCD and nicotine/MβCD inclusion complex gels are 14 and 10 times as much as the pure nicotine gel, respectively. Therefore, the encapsulation of nicotine with βCD and MβCD can be used to enhance the stability and skin permeation application of nicotine-containing products.

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“…Ethanol is generally used as a co-solvent to improve encapsulation efficiency for various host and guest molecules [25]. In order to obtain the highest encapsulation efficiency, the effect of ethanol concentration on the amount of encapsulated linalool was evaluated.…”

Section: Linalool/cd Inclusion Complex Formationmentioning

confidence: 99%

The Preservation and Enantiomeric Selection of Linalool by Nanoencapsulation Using Cyclodextrins

et al. 2021

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Linalool, a volatile terpene alcohol, is responsible for a characteristic aroma in food, beverages, and cosmetics. However, linalool’s low aqueous solubility and high volatility limit the applications and shelf life of linalool-containing products. Nanoencapsulation using beta-cyclodextrin (BCD), methyl-beta-cyclodextrin (MBCD) and hydroxypropyl-beta-cyclodextrin (HPBCD) was studied to improve the aqueous solubility and stability of linalool. Linalool has two enantiomers with distinct flavors and odors which affect product quality. The enantiomeric selectivity of the cyclodextrins (CDs) toward racemic linalool standard was evaluated. A computational simulation was performed to predict the conformations and interactions of the inclusion complexes. The 1:1 host-guest ratio from the computer simulation was implemented in the experimental study. Phase solubility study shows an improvement in linalool aqueous solubility after being encapsulated by CDs. The encapsulation efficiencies of linalool/BCD, linalool/MBCD, and linalool/HPBCD inclusion complexes are 66.30%, 51.38% and 32.31%, respectively. Nanoencapsulation by CDs can preserve linalool in the form of inclusion complexes compared to its free form. The amount of remaining linalool in linalool/BCD, linalool/MBCD, and linalool/HPBCD inclusion complexes are 89.57%, 87.07%, and 74.86%, respectively which are considerably larger than that of pure linalool (42.30%). CDs also show the enantiomeric selectivity toward (R)-linalool as evident from (R)-linalool percentage of 54.53% in the inclusion complex.

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Encapsulation of plumbagin using cyclodextrins to enhance plumbagin stability: computational simulation, preparation, characterization, and application

Cited by 11 publications

References 40 publications

Functional Characteristics and Physical Properties of Spray Dried Starch Inclusion Complexes with Drugs

Functional Characteristics and Physical Properties of Spray Dried Starch Inclusion Complexes with Drugs

Stability Enhancement and Skin Permeation Application of Nicotine by Forming Inclusion Complex with β-Cyclodextrin and Methyl-β-Cyclodextrin

The Preservation and Enantiomeric Selection of Linalool by Nanoencapsulation Using Cyclodextrins

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