Functional Characteristics and Physical Properties of Spray Dried Starch Inclusion Complexes with Drugs

Abstract

Starch systems containing bioactive compounds (ibuprofen, acetylsalicylic acid, paracetamol, myristic acid) are produced in a pilot plant scale spray dryer. The obtained powders are characterized in terms of their physical properties namely moisture, solubility, bulk and tapped density, suspensibility, hygroscopicity, cohesiveness, flowability, and particle size. The effect of spray drying processing parameters and storage relative humidity on the physical properties of powders is investigated. Light microscopy and Confocal Laser Scanning Microscopy (CLSM) are used to characterize the morphology of the powders and assess possible interaction of amylose with the bioactive compounds. A multiple response optimization is performed to determine the optimal physical properties for achieving the ideal powder formulation that jointly satisfy the spray drying operating conditions. Results revealed that the physical properties of powders are mainly affected by the different operating conditions employed during spray drying. All samples displayed significant differences in their physical properties. Microscopic examination showed the presence of disrupted and intact starch granules, albeit swollen. The optimal processing parameters for the production of spray dried powders with more satisfactory physical properties are obtained at high inlet temperatures. Principal component analysis (PCA) and cluster analysis (CA) showed that there are strong positive correlations among the physical properties of the powders.

Biodegradable Films from Spray Dried Starch Inclusion Complexes with Bioactive Compounds—The Effect of Glycerol and pH

“…[ 35,64 ] Considering that corn starch and pregelatinized corn starch have the same content of amylose, the observed differences are presumably related to the absence of starch granules, in the pregel starch, which when present hinder the interaction of guest molecules with amylose trapped inside the granules. This could be further verified from the results obtained from our previous studies [ 36–39 ] and optical microscopic analysis (Section 3.5). Similar observations on TS at high glycerol content were also reported by Tang et al., [ 65,66 ] Mansour et al., [ 41,42 ] and Tarique et al.…”

“…The preparation and physical characterization of the spray dried starch inclusion complexes with drugs and bioactive compounds and the operating conditions employed during the drying process, were described in detail in the previous work. [ 39 ]…”

“…The thermoplastic films were impregnated with a Nile red solution (1 g L −1 in methanol) and allowed to be diffused by the stain at 4 °C for 12 h. Concomitantly, the films were centrifuged to remove the surplus stain solution (at 4200 × g for 30 min) and allowed to dry at 25 °C under a continuous laminar air current. [ 39 ]…”

“…In earlier work by our group, the production of starch molecular inclusion complexes containing fatty acids (myristic acid, palmitic acid) and drugs (ibuprofen, acetylsalicylic acid, paracetamol) has been studied using a pilot plant scale spray dryer. [ 36–39 ] Results revealed that the spray drying technique contributes to the formation of starch inclusion complexes with excellent properties. [ 36–39 ] These systems have potential industrial application in food, cosmetics, and pharmaceuticals.…”

“…[ 36–39 ] Results revealed that the spray drying technique contributes to the formation of starch inclusion complexes with excellent properties. [ 36–39 ] These systems have potential industrial application in food, cosmetics, and pharmaceuticals. To the best of our knowledge as for the time being there are no studies investigating the preparation and characterization of biodegradable films using as primary material spray‐dried starch molecular inclusion complexes.…”