Encapsulation of NSAIDs for inflammation management: Overview, progress, challenges and prospects

Badri, Waisudin; Miladi, Karim; Nazari, Qand Agha; Greige‐Gerges, Hélène; Fessi, Hatem; Elaı̈ssari, Abdelhamid

doi:10.1016/j.ijpharm.2016.11.002

Cited by 96 publications

(45 citation statements)

References 125 publications

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“…Therefore, the development of selective COX-2 inhibitors was a strategy in the pipeline for new anti-inflammatory compounds. These selective inhibitors, called coxibs, improved the efficacy of NSAIDs and diminished their damage to the gastrointestinal tract; however, they increased the risk of cardiotoxicity and hepatotoxicity [ 13 ]. For this reason, several drugs already approved by the Food and Drug Administration (FDA) were removed from the market.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

Coutinho

Pacheco

Frozza

et al. 2018

IJMS

206

118

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Inflammation is the principal response invoked by the body to address injuries. Despite inflammation constituting a crucial component of tissue repair, it is well known that unchecked or chronic inflammation becomes deleterious, leading to progressive tissue damage. Studies over the past years focused on foods rich in polyphenols with anti-inflammatory and immunomodulatory properties, since inflammation was recognized to play a central role in several diseases. In this review, we discuss the beneficial effects of resveratrol, the most widely investigated polyphenol, on cancer and neurodegenerative, respiratory, metabolic, and cardiovascular diseases. We highlight how resveratrol, despite its unfavorable pharmacokinetics, can modulate the inflammatory pathways underlying those diseases, and we identify future opportunities for the evaluation of its clinical feasibility.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

Coutinho

Pacheco

Frozza

et al. 2018

IJMS

206

118

View full text Add to dashboard Cite

show abstract

“…The blocking of COX-1 enzymes, and the loss of these desirable regulatory functions, causes the unsavory side-effects associated with NSAID usage: stomach ulcers and excessive bleeding. 1 NSAIDs that selectively target only COX-2 have been developed. The active site of COX-2 is slightly larger than that of COX-1, allowing selectivity to be achieved through the use of drugs which are too bulky to access the polar arginine in COX-1.…”

Section: Impact Statementmentioning

confidence: 99%

“…However, the majority of the NSAIDs used across the globe are prescribed in primary healthcare. 1 When tissue experiences injury, due to things like infection or trauma, the body responds by initiating inflammation. In most cases, this inflammation is a good thing, and causes eventual resolution of injury, including clearance of the injurious stimuli and replacement of normal function.…”

Section: Introductionmentioning

confidence: 99%

Localized and targeted delivery of NSAIDs for treatment of inflammation: A review

Haley

Recum

2018

Exp Biol Med (Maywood)

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Inflammatory processes are increasingly being identified at the core of many different disease states (e.g. heart disease, cancer, diabetes). As such, anti-inflammatory strategies available through drug delivery have undergone renewed interest. Due to the systemic side effects of steroidal drugs, non-steroidal anti-inflammatory drugs are often preferred for long-term treatment of inflammation in a variety of applications. While non-steroidal anti-inflammatory drugs are generally safe, there are some serious side effects that can be associated with their usage, particularly when given systemically or orally. Due to the high number of patients taking non-steroidal anti-inflammatory drugs, the reduction or elimination of these side effects, such as is possible through local drug delivery, could have a very powerful effect on patient quality of life. This review comments on a sampling of existing methods for localized or targeted delivery of non-steroidal anti-inflammatory drugs, with the goal of helping future research groups to focus on bettering methods shown to be effective and filling the gaps of knowledge in this field. Additionally, commentary is made on the field as a whole, and the standardization issues that arise from its expansiveness and diversity. Impact statement This work provides an overview of research currently being done exploring potential drug delivery device strategies for NSAIDs as an alternative to systemic delivery. Commentary on this field is made in an attempt to aid future experimental design, enabling researchers to determine the drugs and delivery vehicles which are most advantageous for them to pursue, as well as suggestions to standardize the reporting of such future research.

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“…On the other hand, liposomes are already being used as carriers of NSAIDs, nonspecific inhibitors of the cycloxygenase pathway thus suppressing the generation of inflammation mediators such as prostaglandins. Encapsulation plays a pivotal role in improving the efficacy, safety and tolerability of these active molecules [35]. For example, the significantly greater antinociceptive response exhibited by diclofenac loaded liposomes with respect to the nonencapsulated form, has been attributed to an enhanced drug solubility and more effective delivery of the loaded diclofenac to the targeted area [36].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Current progress and challenges of nanoparticle-based therapeutics in pain management

Andreu

Arruebo

2018

Journal of Controlled Release

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Pain is a widespread and growing health problem worldwide that exerts a considerable social and economic impact on both patients and healthcare systems and, therefore, on society in general. Although current treatment modalities include a wide variety of pharmacological and non-pharmacological approaches, due to the complexity of pain and individual differences in clinical response these options are not always effective in mitigating and relieving pain. In addition, some pain drugs such as non-steroidal anti-inflammatory drugs (NSAIDs), local anesthetics and opioids show several unfavorable side effects. Therefore, current research advances in this medical field are based on the development of potential treatments to address many of the unmet needs and to overcome the existing limitations in pain management. Nanoparticle drug delivery systems present an exciting opportunity as alternative platforms to improve efficacy and safety of medications currently in use. Herein, we review a broad range of nanoparticle formulations (organic nanostructures and inorganic nanoparticles), which have been developed to encapsulate an array of painkillers, paying special attention to the key advantages that these systems offer, (compared to the use of the free drug), as well as to the more relevant results of preclinical studies in animal models. Additionally, we will briefly discuss the impact of some of these nanoformulations in clinical trials.

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Encapsulation of NSAIDs for inflammation management: Overview, progress, challenges and prospects

Cited by 96 publications

References 125 publications

Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights

Localized and targeted delivery of NSAIDs for treatment of inflammation: A review

Current progress and challenges of nanoparticle-based therapeutics in pain management

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