Encapsulation of liquid cores by layer-by-layer adsorption of polyelectrolytes

Szczepanowicz, Krzysztof; Dronka-Góra, Dorota; Para, Grażyna; Warszyński, Piotr

doi:10.1080/02652040903052069

Cited by 11 publications

(9 citation statements)

References 26 publications

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“…Later on, the method was used to create a polyelectrolyte multilayer shell on a liquid nanocore. In the study, nanocapsules were synthesized according to the method described by , 22 i.e., the direct encapsulation of emulsion drops in polyelectrolyte multilayer shells. Briefly, the oil phase was prepared by dissolution of 340 g/dm 3 AOT in chloroform.…”

Section: Methodsmentioning

confidence: 99%

Biocompatible Polymeric Nanoparticles as Promising Candidates for Drug Delivery

et al. 2015

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The use of polymeric nanoparticles (NPs) in pharmacology provides many benefits because this approach can increase the efficacy and selectivity of active compounds. However, development of new nanocarriers requires better understanding of the interactions between NPs and the immune system, allowing for the optimization of NP properties for effective drug delivery. Therefore, in the present study, we focused on the investigation of the interactions between biocompatible polymeric NPs and a murine macrophage cell line (RAW 264.7) and a human monocytic leukemia cell line (THP-1). NPs based on a liquid core with polyelectrolyte shells were prepared by sequential adsorption of polyelectrolytes (LbL) using AOT (docusate sodium salt) as the emulsifier and the biocompatible polyelectrolytes polyanion PGA (poly-l-glutamic acid sodium salt) and polycation PLL (poly l-lysine). The average size of the obtained NPs was 80 nm. Pegylated external layers were prepared using PGA-g-PEG (PGA grafted by PEG poly(ethylene glycol)). The influence of the physicochemical properties of the NPs (charge, size, surface modification) on viability, phagocytosis potential, and endocytosis was studied. Internalization of NPs was determined by flow cytometry and confocal microscopy. Moreover, we evaluated whether addition of PEG chains downregulates particle uptake by phagocytic cells. The presented results confirm that the obtained PEG-grafted NPs are promising candidates for drug delivery.

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Section: Methodsmentioning

confidence: 99%

Biocompatible Polymeric Nanoparticles as Promising Candidates for Drug Delivery

et al. 2015

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“…Nanocapsules were synthesized using the method described by Szczepanowicz et al [31] and repeatedly cited in further papers [11,16,[32][33][34][35][36]. Briefly, nanocapsules' synthesis was based on direct encapsulation of emulsion cores in (bio)polyelectrolyte multilayer shells.…”

Section: Nanocapsules' Synthesismentioning

confidence: 99%

Polyelectrolyte-coated nanocapsules containing undecylenic acid: Synthesis, biocompatibility and neuroprotective properties

Piotrowski

Jantas

Szczepanowicz

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…However, commodity polymers and bio-based materials often have limited thermal stability. The formation of nanocapsules is often based on phase separation in mini-emulsion polymerization [20], micellar assembly of block copolymers [21], layer-by-layer adsorption of polyelectrolytes [22], polymer brush grafting [23], or dendrimer synthesis [24]. Vegetable oils have been used as core materials in cationic polymeric nanocapsules [25], but the use of appropriate surfactants remains generally required.…”

Section: Introductionmentioning

confidence: 99%