Encapsulation of Gold Nanorods with Porphyrins for the Potential Treatment of Cancer and Bacterial Diseases: A Critical Review

Hlapisi, Nthabeleng; Motaung, T.E.; Linganiso, Linda Z.; Oluwafemi, Oluwatobi S.; Songca, Sandile P.

doi:10.1155/2019/7147128

Cited by 25 publications

(19 citation statements)

References 289 publications

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“…In their study examining the cytotoxicity and genotoxicity of Ag acteristics (Hlapisi, Motaung, Linganiso, Oluwafemi, & Songca, 2019;Zarska et al, 2016). Since they are widely used in biomedicine as contrast agents, drug delivery systems, or as agents in phototherapeutic approaches like PTT (Alkilany, Thompson, Boulos, Sisco, & Murphy, 2012), biosafety of these novel agents must be carefully investigated in great detail.…”

Section: Perez Et Al (2016)mentioning

confidence: 99%

“…Au NRs, with their exceptional optical and physical properties, offer a vast array of applications in biomedical technologies, optoelectronic devices, and plasmon‐enhanced spectroscopy. Au NRs are preferred in the diagnosis and treatment of cancer on account of their excellent optical characteristics (Hlapisi, Motaung, Linganiso, Oluwafemi, & Songca, 2019; Zarska et al, 2016). Since they are widely used in biomedicine as contrast agents, drug delivery systems, or as agents in phototherapeutic approaches like PTT (Alkilany, Thompson, Boulos, Sisco, & Murphy, 2012), biosafety of these novel agents must be carefully investigated in great detail.…”

Section: Non‐magnetic Metallic Nanomaterialsmentioning

confidence: 99%

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A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials

Demir

2020

J of Applied Toxicology

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Nanomaterials (NMs) generally display fascinating physical and chemical properties that are not always present in bulk materials; therefore, any modification to their size, shape, or coating tends to cause significant changes in their chemical/physical and biological characteristics. The dramatic increase in efforts to use NMs renders the risk assessment of their toxicity highly crucial due to the possible health perils of this relatively uncharted territory. The different sizes and shapes of the nanoparticles are known to have an impact on organisms and an important place in clinical applications. The shape of nanoparticles, namely, whether they are rods, wires, or spheres, is a particularly critical parameter to affect cell uptake and site-specific drug delivery, representing a significant factor in determining the potency and magnitude of the effect. This review, therefore, intends to offer a picture of research into the toxicity of different shapes (nanorods, nanowires, and nanospheres) of NMs to in vitro and in vivo models, presenting an in-depth analysis of health risks associated with exposure to such nanostructures and benefits achieved by using certain model organisms in genotoxicity testing. Nanotoxicity experiments use various models and tests, such as cell cultures, cores, shells, and coating materials. This review article also attempts to raise awareness about practical applications of NMs in different shapes in biology, to evaluate their potential genotoxicity, and to suggest approaches to explain underlying mechanisms of their toxicity and genotoxicity depending on nanoparticle shape.

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Section: Perez Et Al (2016)mentioning

confidence: 99%

Section: Non‐magnetic Metallic Nanomaterialsmentioning

confidence: 99%

A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials

Demir

2020

J of Applied Toxicology

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“…All of these characteristics along with the fact that the biological transparency window (~600-1000 nm) coincides with the longitudinal plasmon band of GNRs, ref. [33] make gold nanorods suitable agents to aid in the clinical diagnosis and treatment of cancer with high accuracy and sensitivity, such as through CT-guided photothermal therapy [34,35], photodynamic therapy [36], and cancer radiotherapy [37].…”

Section: Introductionmentioning

confidence: 99%

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization

Terracciano

Zhang

Simeral

et al. 2021

JNT

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Due to their well-defined plasmonic properties, gold nanorods (GNRs) can be fabricated with optimal light absorption in the near-infrared region of the electromagnetic spectrum, which make them suitable for cancer-related theranostic applications. However, their controversial safety profile, as a result of surfactant stabilization during synthesis, limits their clinical translation. We report a facile method to improve GNR biocompatibility through the presence of sodium dodecyl sulfate (SDS). GNRs (120 × 40 nm) were synthesized through a seed-mediated approach, using cetyltrimethylammonium bromide (CTAB) as a cationic surfactant to direct the growth of nanorods and stabilize the particles. Post-synthesis, SDS was used as an exchange ligand to modify the net surface charge of the particles from positive to negative while maintaining rod stability in an aqueous environment. GNR cytotoxic effects, as well as the mechanisms of their cellular uptake, were examined in two different cancer cell lines, Lewis lung carcinoma (LLC) and HeLa cells. We not only found a significant dose-dependent effect of GNR treatment on cell viability but also a time-dependent effect of GNR surfactant charge on cytotoxicity over the two cell lines. Our results promote a better understanding of how we can mediate the undesired consequences of GNR synthesis byproducts when exposed to a living organism, which so far has limited GNR use in cancer theranostics.

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“…CTAB is used as a soft template in the seed-mediated method. However, studies have shown that it is one major cause of AuNRs toxicity [6][7][8][9]. Therefore, it is essential to find biocompatible, non-toxic, and stable surface modifying agents to passivate Au-NRs and reduce their toxicity whilst maintaining their optical properties [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of NIR-II Absorbing Gelatin Stabilized Gold Nanorods and Its Photothermal Therapy Application against Fibroblast Histiocytoma Cells

et al. 2021

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The excellent photothermal properties of gold nanorods (Au-NRs) make them one of the most researched plasmonic photothermal nanomaterials. However, their biological applications have been hampered greatly due to surfactant-induced cytotoxicity. We herein report a simple synthesis of highly biocompatible gelatin stabilized Au-NRs (gelatin@Au-NRs) to address this issue. The optical and structural properties of the as-synthesized gelatin@Au-NRs were investigated by Zetasizer, Ultraviolet-Visible-Near Infrared (UV-Vis-NIR) spectroscopy, high-resolution transmission electron microscopy (HR-TEM), and Fourier transform infrared spectroscopy (FTIR). The as-synthesized gelatin@Au-NRs were highly crystalline and rod-like in shape with an average length and diameter of 66.2 ± 2.3 nm and 10 ± 1.6 nm, respectively. The as-synthesized gelatin@Au-NRs showed high stability in common biological media (phosphate buffer saline and Dulbecco’s Modified Eagle’s Medium) compared to CTAB capped Au-NRs. Similarly, the gelatin@Au-NRs showed an improved heat production and outstanding cell viability against two different cancer cell lines; KM-Luc/GFP (mouse fibroblast histiocytoma cell line) and FM3A-Luc (breast carcinoma cell line) compared to CTAB capped Au-NRs and PEG@Au-NRs. An in vitro photothermal therapy study against KM-Luc/GFP showed that gelatin@Au-NRs effectively destroys the cancer cells.

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Encapsulation of Gold Nanorods with Porphyrins for the Potential Treatment of Cancer and Bacterial Diseases: A Critical Review

Cited by 25 publications

References 289 publications

A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials

A review on nanotoxicity and nanogenotoxicity of different shapes of nanomaterials

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization

Synthesis of NIR-II Absorbing Gelatin Stabilized Gold Nanorods and Its Photothermal Therapy Application against Fibroblast Histiocytoma Cells

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