Encapsulation of folic acid in food hydrocolloids through nanospray drying and electrospraying for nutraceutical applications

Abstract

In this work, two different technologies (electrospraying and nanospray drying) were evaluated for encapsulation of folic acid using a whey protein concentrate (WPC) matrix and a commercial resistant starch. The morphology of the capsules, molecular organization of the matrices, encapsulation efficiency, and stability of folic acid within the capsules under different storage conditions and upon thermal exposure were studied. Results showed that spherical submicro-and microcapsules were obtained through both techniques, although electrospraying led to smaller capsule sizes and to an enhanced control over their size distribution. Greater encapsulation efficiency was observed using WPC as encapsulating matrix, probably related to interactions between the protein and folic acid which favoured the incorporation of the bioactive. The best results in terms of bioactive stabilization in the different conditions assayed were also obtained for the WPC capsules, although both materials and encapsulation techniques led to improved folic acid stability, especially under dry conditions. Highlights Folic acid was encapsulated through nanospray drying and electrospraying  A whey protein and a resistant starch were used as encapsulating matrices  Spherical nano-, submicro-and microcapsules were obtained through both techniques  Greater encapsulation efficiency was observed for the protein-based capsules  Both materials and encapsulation techniques led to improved folic acid stability

Zein nanoparticles for oral folic acid delivery

“…Under these experimental conditions, folic acid-loaded zein nanoparticles displayed a mean size after reconstitution of about 200 nm with a negative zeta potential of À24 mV and a low polydispersity index ( Table 1). The folic acid content was close to 54 mg/mg nanoparticles, which is approximately 3-times higher than the payload reported by Perez-Masi a and collaborators who used nano-and microcapsules from either whey protein or starch [34].…”

Emerging trends in nutraceutical applications of whey protein and its derivatives

“…The encapsulation was traced down to the favourable interactions between the protein and folic facilitating incorporation of the vitamin. Empirical results showed that whey protein concentrate serve better than the commercial resistant starch for folic acid stability (Pérez-Masiá et al 2015). This study assessed the oxygen-scavenging potential of an edible whey protein isolate film impregnated with ascorbic acid.…”

Optimized conditions to produce water-in-oil-in-water nanoemulsion and spray-dried nanocapsule of red ginseng extract

“…The shape and type of capsule formed are influenced by procedure of emulsification with core and coating materials and drying process (Rosenberg et al, 1990). Recently, Pérez-Masiá et al (2015) reported that spray drying is very efficient for the production of nanocapsule of folic acid in food hydrocolloids.…”