Encapsulation of (─)-epigallocatechin-3-gallate (EGCG) in solid lipid nanoparticles for food applications

Shtay, Rasha; Keppler, Julia K.; Schrader, Katrin; Schwarz, Karin

doi:10.1016/j.jfoodeng.2018.09.008

Cited by 66 publications

(30 citation statements)

References 43 publications

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“…HPH is one of the most used methods in SLN/NLC preparation for the encapsulation of phenolic compounds. Shtay et al prepared SLNs loaded with EGCG using a hot high-pressure homogenization method with slight modifications [ 72 ]. For this, the authors used cocoa butter, mono- and diglycerides (MDG), and sodium stearoyl-2-lactylate (SSL).…”

Section: Preparation Methods and Functionalization Approachesmentioning

confidence: 99%

“…The final solution was then homogenized using a high-pressure homogenizer and then cooled. In vitro release studies were carried out using simulated gastric fluid (SGF, pH 1.2) and intestinal fluid (SIF, pH 6.8) and a more prolonged release was observed in both conditions, which will possibly lead to an improved bioavailability of EGCG [ 72 ]. Similarly, Trombino et al prepared SLNs loaded with trans-ferulic acid using a high pressure homogenization method [ 73 ].…”

Section: Preparation Methods and Functionalization Approachesmentioning

confidence: 99%

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Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds

et al. 2020

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Phenolic compounds are one of the most widespread classes of compounds in nature, with several beneficial biological effects being associated with their anti-oxidant and anti-carcinogenic activities. Their application in the prevention or treatment of numerous chronic diseases have been studied, but a major drawback is still the low bioavailability of these compounds, as well as their instability towards pH, temperature, and light in some cases. Nanotechnology has emerged as an alternative to overcome these limitations, and the use of lipidic encapsulation systems is a promising technique to achieve an efficient drug delivery, protecting molecules from external factors and improving their bioavailability. In this review, solid lipid nanoparticles and nanostructured lipid carriers are highlighted as an important tool for the improvement of the bioavailability and stability of natural phenolic compounds, including their preparation methods and functionalization approaches and the discussion of several applications for putative use in cosmetic and pharmacologic products.

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Section: Preparation Methods and Functionalization Approachesmentioning

confidence: 99%

Section: Preparation Methods and Functionalization Approachesmentioning

confidence: 99%

Solid Lipid Nanoparticles as Carriers of Natural Phenolic Compounds

et al. 2020

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“…Furthermore, the poor permeability and the highly affinity to intestinal P-glycoprotein efflux mechanism. All of the introduced drawbacks leading to great low oral bioavailability of EGCG despite its high water solubility (Shtay et al, 2019). Hence, the previously studies reported to overcome these drawbacks and enhancing the oral bioavailability of EGCG through incorporation of EGCG in nanodelivery systems as liposomes (Zou et al, 2014).…”

Section: Intoductionmentioning

confidence: 99%

Preparation and Characterization of (−)-Epigallocatechin Gallate Lipid Based Nanoparticles for Enhancing Availability and Physical Properties

Eltawela

2021

Al-Azhar Journal of Pharmaceutical Sciences

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(−)-Epigallocatechin gallate (EGCG) is the most abundant and biologically active polyphenol found in green tea. (−)-Epigallocatechin gallate (EGCG) is highly potent antioxidant therefore, it has great therapeutic effect against cancer disease. Furthermore, it has antibacterial and anti-inflammatory effect. but it has some limitations, such as the poor permeability, the highly affinity to intestinal P-glycoprotein efflux mechanism and short half-life. Therefore, it has very low oral bioavailability. In current study, Precirol ® ATO 5 (P), glyceryl monostearate (GMS) and Compritol ® 888 ATO (C) were selected as solid lipids and miglyol (M) and sesame oil (SO) as liquid lipids, to develop EGCG-NLC (nanostructured lipid carrier) and EGCG-SLN (solid lipid nanoparticles). EGCG was successfully encapsulated into lipid nanoparticles to improve its bioavailability. EGCG-NLC and EGCG-SLN were formulated using a hot homogenization-ultrasonication technique, and the physicochemical properties were characterized. The developed EGCG-NLCs and EGCG-SLNs showed small and homogeneous particle size approximately (308 and 379 nm) with entrapment efficiency around (76 and 49%), respectively. Also, the resulted formulation EGCG-NLC3 appeared under transmission electron microscope in almost spherical shape.

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“…One example of the sensitive herbals is Epigallocatechin-3-gallate (EGCG) being vulnerable to pH, temperature, and oxygen, thus restricting its applications. Incorporation of EGCG into solid lipid nanoparticles (SLNs) was found to enhance its stability under both gastric and intestinal conditions with a prolonged release of about 21.8% of the drug at the end of the incubation in SIF (pH = 6.8, containing pancreatin) at 37°C [16]. In addition to lipid nanocarriers, the efficient mucoadhesive nature of chitosan nanoparticles encouraged its use for entrapment of EGCG to facilitate its adsorption to the intestinal wall, and hence increase its absorption and bioavailability.…”

Section: Increased Stabilitymentioning

confidence: 99%