Encapsulation of drug microparticles with self‐assembled Fe₃O₄/alginate hybrid multilayers for targeted controlled release

Abstract

The magnetic-targeted drug-delivery system was developed with the Fe(3)O(4) nanoparticles as the self-assembling material to form the hybrid multilayer shells. Layer-by-Layer stepwise self-assembly of the natural polyelectrolytes sodium alginate and the Fe(3)O(4) nanoparticles was used to create the magnetic hybrid multilayers around drug microparticles (~400 nm in diameter) for the purpose of targeted controlled release. The obtained drug microparticles encapsulated with hybrid multilayers were characterized with dynamic light scattering, transmission electron microscope, and vibrating sample magnetometer. UV-vis spectroscopy was employed to monitor the drug releasing behaviors in pH 1.8 and 7.4 buffer solutions. It was found that the release of drug molecules from the pH-sensitive magnetic-targeted drug-delivery system was mainly dependent on the following factors: the permeability of the hybrid multilayer shells and the solubility of the drug molecules in the bulk solutions. The results revealed that it could achieve the quick and continuous controlled release via the magnetically-guide to the target tissue of organism.

Synthesis and Controlled Release Behavior of Biodegradable Polymers with Pendant Ibuprofen Group

“…In recent years, many developments in the drug delivery system have been focusing on the target release [6], controlled release [7], extended time of drug action [8], and so on. For ibuprofen, several methods for the preparation of drug carriers have been reported to solve the issues appearing in the direct use of drug.…”

Layer-by-layer nanoencapsulation of camptothecin with improved activity

“…LbL assembly provides an opportunity to form a nano-thick coating in a controllable manner on the surfaces of variable curvature and size from interacting oppositely charges polyelectrolyte components (Shutava et al, 2012; Lvov, 2000; Sukhorukov, 2002; De Geest et al, 2009; Schneider and Decher, 2004; Chodanowski and Stoll, 2001; Li et al, 1994; Kong et al, 1998; Vertegel et al, 2004; Mu et al, 2012; Lu and Liu, 2012). Anchored to the core surface, the thin shell of hydrophilic polyelectrolytes allow exchange of excipients used on the core preparation.…”

Layer‐by‐Layer Coating of Solid Drug Cores: A Versatile Method to Improve Stability, Control Release and Tune Surface Properties

“…Additional beneficial properties of the coating may be gained by including nanoparticles in the multilayer shell . For example, inclusion of paramagnetic particles could potentially enable magnetic‐driven delivery of the drug cores to the target disease area.…”

“…For example, inclusion of paramagnetic particles could potentially enable magnetic‐driven delivery of the drug cores to the target disease area. For example, preliminary experiments demonstrated that applying a magnet to a vessel containing dipyridamole particles coated with shell incorporating superparamagnetic iron (II, III) oxide nanoparticles resulted in their clustering, which suggest their potential for magnetic guidance in vivo …”