Encapsulation of curcumin in cyclodextrin-metal organic frameworks: Dissociation of loaded CD-MOFs enhances stability of curcumin

Moussa, Zeinab; Hmadeh, Mohamad; Abiad, Mohamad G.; Dib, Omar Hussein; Patra, Digambara

doi:10.1016/j.foodchem.2016.06.013

Cited by 168 publications

(84 citation statements)

References 39 publications

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“…The seven MOF used in this study were previously synthesized in our laboratory (Yilmaz et al, ) at around 100 g for each following the techniques given in the literature. These MOF were the titaniumbutoxide‐terephthalate MOF (Ti‐MOF) synthesized following the method of Vlasova et al (); the gamma‐cyclodextrine‐potassium hydroxide MOF (γ‐CD‐MOF) synthesized according to Moussa et al (); the chrome nitrate‐terephthalate MOF (Cr‐MOF) synthesized by the method of Li et al (); the aluminum‐MOF (Al‐MOF) synthesized according to Ma et al () with some modifications; the zinc nitrate‐2,5‐furandicarboxylic acid‐MOF (Zn‐MOF) synthesized following the solvothermal reaction given in Bu et al (); the magnesium‐MOF (Mg‐MOF) synthesized by following the technique of Spanopoulos et al () with some modifications; and the zinc‐2‐methylimidazole zeolytic type MOF (ZIF‐8‐MOF) synthesized according to Park et al (). After synthesis, these MOF were placed into colored glasses and stored at ambient temperature during the study.…”

Section: Methodsmentioning

confidence: 99%

Regeneration of Used Frying Oils by Selected Metal–Organic Frameworks as Adsorbents

Yılmaz

Güner

2018

J Americ Oil Chem Soc

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The aim of this study was to utilize seven synthesized metal-organic frameworks (MOF) and three natural clays as adsorbents in regenerating used frying oil. First, surface and pore properties, and morphologies of the adsorbents were determined, and used frying oil was treated at 0.1% addition (w/w) level. Then, physicochemical properties, mineral, and fatty-acid compositions of oil were analyzed. Finally, a recycling study was performed over five cycles with three selected adsorbents. Although there were only small improvements in oil color values, oil turbidity was significantly reduced with the adsorbents. Free fatty acidity values were reduced by 50.6% and 42.2% with Ti-MOF and zeolitic-MOF (ZIF-8-MOF) adsorbent treatments. Likewise, peroxide value reductions ranged from 43.6% with the Ti-MOF to 18.1% with natural zeolite. Reductions in the total polar materials (TPM) were the highest (42.5%) with aluminum-MOF (Al-MOF) followed by the ZIF-8-MOF (40.4%). Contents of aluminum, zinc, phosphorous, chromium, magnesium, and potassium were measured in the control and adsorbent-treated oil samples, and it was found that there was no leakage of minerals from the MOF into the oil, but rather some reductions due to adsorption. Furthermore, recycling studies with Ti-MOF, Cr-MOF, and sepiolite showed that the MOF can be used up to five times with only small activity losses compared with sepiolite. Overall, this study demonstrated the great potential of the MOF as adsorbents for frying oil regeneration, and pointed out that more research needed to design and synthesize new MOF structures for applying in the edible oil industry.

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Section: Methodsmentioning

confidence: 99%

Regeneration of Used Frying Oils by Selected Metal–Organic Frameworks as Adsorbents

Yılmaz

Güner

2018

J Americ Oil Chem Soc

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“…Cur was firstly dissolved in ethanol and then added into the Ly NPs solution with different final concentrations (5, 8, 10, 13 mg/ mL) for encapsulation according to previous reports as described in Figure 1 (Naksuriya et al, 2015). Cur concentration was determined using a UV-vis spectrophotometer (UV-1100, MAPADA) at 428 nm (Moussa, Hmadeh, Abiad, Dib, & Patra, 2016;Nazari-Vanani, Moezi, & Heli, 2017). Free Cur (the supernatant solution) solution was obtained after centrifugation at 1888 g for 30 min at 4°C, and the content of Cur was estimated from a standard X-Y plot of Cur (dissolved in ethanol) versus concentration.…”

Section: Cur Encapsulation Based On Ly Npsmentioning

confidence: 99%

Curcumin encapsulation and protection based on lysozyme nanoparticles

Cui

Zhou

Huang

et al. 2019

Food Science & Nutrition

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Curcumin possesses antioxidant, anti‐inflammatory, and other properties. However, this compound exhibits low bioavailability because of its poor solubility and stability. In this paper, lysozyme nanoparticles were fabricated through solvent evaporation, and then, the solubilization and protection capability of curcumin were investigated. Lysozyme nanoparticles were characterized by dynamic light scattering technique, atomic force microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy. The load capacity and stability in thermal environment were further explored. Results showed that the lysozyme nanoparticle displayed a spherical structure (127.9 ± 2.12 nm) with favorable distribution. The solubility of curcumin can increase to 22 μg/mL. After encapsulation by lysozyme nanoparticles, the retentive curcumin can reach up to 67.9% and 30.25% at 25°C and 50°C, respectively, significantly higher than that of free curcumin. Meanwhile, experiments on DPPH free radicals indicated the curcumin loaded by lysozyme nanoparticle possessed higher free radical scavenging activity than that of free curcumin with same treatments. The results confirmed that lysozyme nanoparticles exhibit potential applications in solubilizing and protecting the environment‐sensitive hydrophobic functional components.

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“…The MOFs used in this study were selected based on their safety knowledge for food applications, and synthesized in our laboratory at grams level with the given methods in the literature. The titanium butoxide-terephthalate MOF (Ti-MOF) was synthesized following the method of Vlasova et al 4 ; gamma-cyclodextrine-potassium hydroxide MOF (γ-CD-MOF) was synthesized according to Moussa et al 11 ; chrome nitrate-terephthalate MOF (Cr-MOF) was synthesized by the method of Li et al 12 ; aluminum-MOF (Al-MOF) was synthesized according to Ma et al 8 with some modifications; zinc nitrate-2,5-furandicarboxylic acid-MOF (Zn-MOF) was synthesized following the solvothermal reaction given in Bu et al 13 ; magnesium-MOF (Mg-MOF) was synthesized by following technique of Spanopoulos et al 9 ; and zinc-2-methylimidazole zeolytic type MOF (ZIF-8-MOF) was synthesized according to Park et al 14 The details of the syntheses could be reached in the given literature and in Yilmaz et al 15 Throughout the texts, tables and figures, the abbreviated MOF names given in the above brackets will be used. After enough amounts of synthesis, the MOFs were placed into colored glasses and stored at ambient temperature during the study.…”

Section: Methodsmentioning

confidence: 99%

Off‐Odor Removal from Fish Oil by Adsorbent Treatment with Selected Metal‐Organic Frameworks

Güner

Yılmaz

Yüceer

2019

Flavour & Fragrance J

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The limiting factor for consumption of liquid fish oil is its fishy off‐odor. The objectives of this study were to remove the off‐odors from liquid fish oil by adsorbent treatment with selected metal‐organic frameworks (MOFs), compare their activity with some natural clays, and also observe other changes developed in the oil after the treatments. Seven synthesized MOFs and three natural clays were added at 0.5% (w/w) into fish oil and mixed for 1.5 h at room temperature prior to filtration. The collected oil samples were analyzed for physico‐chemical properties, fatty acid, mineral and volatiles compositions, and sensory descriptions. Results indicated that for all the adsorbents tested, oil physico‐chemical properties improved, while no remarkable change was observed in fatty acid and mineral composition. Volatile composition analysis revealed that 68.8%, 46.2% and 44.5% reductions over total volatile concentrations were achieved using γ‐CD‐MOF, sepiolite and Ti‐MOF adsorbents, respectively. The panel described the oil with fishy, algae‐iodine, green and rancid terms. Some significant decreases in the measured sensory attributes were observed after the adsorbent treatments. Overall, although some significant reductions in volatiles were achieved, some off‐odor characteristics still remained at perceivable level. Hence, further studies focusing on designing specific MOFs are suggested.

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Encapsulation of curcumin in cyclodextrin-metal organic frameworks: Dissociation of loaded CD-MOFs enhances stability of curcumin

Cited by 168 publications

References 39 publications

Regeneration of Used Frying Oils by Selected Metal–Organic Frameworks as Adsorbents

Regeneration of Used Frying Oils by Selected Metal–Organic Frameworks as Adsorbents

Curcumin encapsulation and protection based on lysozyme nanoparticles

Off‐Odor Removal from Fish Oil by Adsorbent Treatment with Selected Metal‐Organic Frameworks

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