Curcumin encapsulation and protection based on lysozyme nanoparticles

Abstract

Curcumin possesses antioxidant, anti‐inflammatory, and other properties. However, this compound exhibits low bioavailability because of its poor solubility and stability. In this paper, lysozyme nanoparticles were fabricated through solvent evaporation, and then, the solubilization and protection capability of curcumin were investigated. Lysozyme nanoparticles were characterized by dynamic light scattering technique, atomic force microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy. The load capacity and stability in thermal environment were further explored. Results showed that the lysozyme nanoparticle displayed a spherical structure (127.9 ± 2.12 nm) with favorable distribution. The solubility of curcumin can increase to 22 μg/mL. After encapsulation by lysozyme nanoparticles, the retentive curcumin can reach up to 67.9% and 30.25% at 25°C and 50°C, respectively, significantly higher than that of free curcumin. Meanwhile, experiments on DPPH free radicals indicated the curcumin loaded by lysozyme nanoparticle possessed higher free radical scavenging activity than that of free curcumin with same treatments. The results confirmed that lysozyme nanoparticles exhibit potential applications in solubilizing and protecting the environment‐sensitive hydrophobic functional components.

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

“…Electrostatic complexation between fibrinogen (Fbg) and HA were stabilized by thermal treatment taking advantage of the thermally-induced intermolecular associations between Fbg molecules [ 71 ]. The nanoparticles formed had NG properties and could encapsulate curcumin a well-known nutraceutical [ 108 ] also promising for bioimaging applications [ 109 ]. In another work, the thermal treatment of BSA within complexes with CS [ 76 ] or xanthan [ 92 ] resulted in stimuli responsive NG-like nanoparticles that could encapsulate the nutraceutical β-carotene or curcumin respectively.…”

Amphiphilic AxBy mikto‐arm star copolymers with PLMA and POEGMA arms: Self‐assembly and drug encapsulation

“…Formulating CUR in nano-structures, that is, nanoparticles has been shown to increase its bioavailability. 27 CUR is an important nutraceutical compound, 28 but its hydrophobic character makes it insoluble in water. In addition, CUR exhibits fluorescent properties and has been recently proposed as a bioimaging agent.…”

Highly Enhanced Curcumin Delivery Applying Association Type Nanostructures of Block Copolymers, Cyclodextrins and Polycyclodextrins

“…The hydrolysis of curcumin (degradation) was controlled by encapsulating it in phospholipid based nanoemulsion [ 6 ]. Lysozyme nanoparticles (d = 130 nm) also proved to be suitable carrier to solubilize curcumin giving a concentration of 10 −2 g/L and providing a protection of the environment sensitive compound [ 7 ]. Drug content in the similar range was achieved using a mixed micellar system of poloxamer and D-α-tocopheryl polyethylene glycol 1000 succinate presenting increased therapeutic efficacy of curcumin [ 8 , 9 ].…”