Encapsulation of active ingredients in polysaccharide–protein complex coacervates

Devi, Nirmala; Sarmah, Mandip; Khatun, Bably; Maji, Tarun K.

doi:10.1016/j.cis.2016.05.009

Cited by 252 publications

(106 citation statements)

References 123 publications

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“…Other coating approaches include complex coacervation and Pickering stabilization. In complex coacervation, colloidal particles are coated by a relatively thick layer of a coacervate phase, which is usually comprised of protein and polysaccharide molecules held together by electrostatic attraction (Devi and others ). In the Pickering method, larger colloidal particles are coated by a layer of smaller colloidal particles that are able to adsorb to their surfaces (Xiao and others ).…”

Section: Overview Of Colloidal Delivery Systemsmentioning

confidence: 99%

Delivery by Design (DbD): A Standardized Approach to the Development of Efficacious Nanoparticle‐ and Microparticle‐Based Delivery Systems

McClements

2017

Comp Rev Food Sci Food Safe

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The design and development of nanoparticle‐ and microparticle‐based delivery systems for the encapsulation, protection, and controlled release of active agents has grown considerably in the agrochemical, cosmetic, food, personal care, and pharmaceutical industries. These colloidal delivery systems can be utilized to overcome problems such as poor solubility, low activity, and chemical instability of active agents, as well as to create novel functional attributes such as controlled or targeted delivery. The purpose of this article is to develop a systematic approach, referred to as “delivery‐by‐design” (DbD), to make the design and fabrication process more efficient and effective. Initially, a brief review of some of the challenges associated with incorporating active agents into commercial products is given, and then an overview of different kinds of simple and complex colloidal delivery systems is given. The DbD approach is then presented as a series of stages: (1) definition of the molecular and physicochemical properties of the active agent; (2) definition of the required physicochemical, sensory, and functional attributes of the end‐product; (3) specification of the required attributes of the colloidal delivery system; (4) specification of particle properties and delivery system selection; (5) optimization of delivery system manufacturing process; (6) establishment and implementation of delivery system testing protocol; and (7) optimization of delivery system performance. Utilization of the DbD approach may lead to more rapid design of efficacious and economically viable colloidal delivery systems for commercial applications.

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Section: Overview Of Colloidal Delivery Systemsmentioning

confidence: 99%

Delivery by Design (DbD): A Standardized Approach to the Development of Efficacious Nanoparticle‐ and Microparticle‐Based Delivery Systems

McClements

2017

Comp Rev Food Sci Food Safe

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“…Microencapsulation of active ingredients is an appropriate approach to prevent their direct contact with environmental stressors including oxygen, heat, moisture and light (Devi et al, 2017;Timilsena et al, 2017). Currently, complex coacervation is regarded as one of the simplest, low-cost methods of microencapsulation of hydrophobic substances with its high loading, controlled release and especially its anti-oxidation capacities (Kaushik et al, 2015;Yuan et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of shiitake (Lentinula edodes) essential oil by complex coacervation: formation, rheological property, oxidative stability and odour attenuation effect

Yuan

Chen

et al. 2018

Int J of Food Sci Tech

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Summary Complex coacervation of gelatin (GE) with carboxymethylcellulose (CMC) and the microencapsulation of shiitake essential oil (SEO) using the GE‐CMC coacervate were investigated. The ζ‐potential and coacervate yield data showed that the optimal complexation pH and CMC/GE ratio were 4.0 and 0.15 g g−1, respectively. At this condition, the coacervate yield was 85.35 ± 4.89% and ζ‐potential was almost zero. The SEO contained microcapsules fabricated by the GE‐CMC coacervate were also electrostatic inducted formation, and the highest encapsulation efficiency was shown to be 85.75 ± 2.89%. The rheological measurement indicated that the GE‐CMC coacervated microcapsules had a viscoelastic solid behaviour (G’ > G”) which was resulted mainly from the interactions between GE molecules and CMC chains. The improved oxidative stability and odour attenuation effect of the GE‐CMC coacervated microcapsules were believed to be attributed to the increased protection against oxidation and flavour release by providing a physical barrier after complex coacervation.

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“…Over the past few decades, the protein–polysaccharide complex has attracted a lot of attention among the colloidal structures due to its potential applications in pharmaceutical, cosmetics, foods, electronics, molecular diagnostic, and agriculture (Devi, Sarmah, Khatun, & Maji, ; Il'ina et al, ). Modification of texture, stabilization of food emulsions and suspensions, production of specific hydrocolloid gels and encapsulation and protection of bioactive ingredients are some of protein–polysaccharide complex applications in various industries.…”

Section: Introductionmentioning

confidence: 99%

“…Modification of texture, stabilization of food emulsions and suspensions, production of specific hydrocolloid gels and encapsulation and protection of bioactive ingredients are some of protein–polysaccharide complex applications in various industries. The encapsulation of bioactive compounds may exert different benefits, for example, protection from several damaging environmental factors, such as light, oxygen, moisture, heat, mechanical stresses, or other destructive agents (Arroyo‐Maya & McClements, ; Devi et al, ), controlling the release of bioactives within foods during storage and also in human gastrointestinal tract, increase in solubility in aqueous foods and covering unfavorable flavor and odor of bioactive ingredients.…”

Section: Introductionmentioning

confidence: 99%

Design, fabrication and characterization of pectin-coated gelatin nanoparticles as potential nano-carrier system

et al. 2018

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The main purpose of this study was to fabricate potential nano‐delivery systems based on protein–polysaccharide complex for use in beverages. In this regard, optimum gelatin–pectin complex (GPC) nano‐carrier with hydrodynamic diameter of ≈200 nm was designed and fabricated using low‐bloom gelatin (BG) and high‐methoxyl pectin (CP) at BG/CP weight ratio of 1:1 (0.025%(w/v) CP on 0.025%(w/v) BG) and pH 4.5. The suspension containing GPC nano‐carrier had very good transparency (14.1NTU). Scanning electron microscopy (SEM) images illustrated that the GPC particles were spherical with fairly smooth surface. Particle size analysis showed that the complex particles had a narrow size distribution (polydispersity index (PDI)≈0.254). Fourier transform infrared (FTIR) confirmed the formation of amide bonds between carboxyl groups in CP and amino groups in BG, and differential scanning calorimetry (DSC) analysis showed the amorphous nature of the GPC nano‐carrier. Finally, the storage stability test indicated that the GPC particles didn't significantly grow after 20 days of storage at 4°C. Practical application The encapsulation of bioactive compounds have different benefits, for example, protection from several damaging environmental factors such as light, oxygen, moisture, heat, mechanical stresses, or other destructive agents, controlling the release of bioactives within foods during storage and also in human gastrointestinal tract, increase in solubility in aqueous foods and covering unfavorable flavor and odor of bioactive ingredients. So that, development of this technic can develops new functional, healthy foods, and foods with new tastes.

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Encapsulation of active ingredients in polysaccharide–protein complex coacervates

Cited by 252 publications

References 123 publications

Delivery by Design (DbD): A Standardized Approach to the Development of Efficacious Nanoparticle‐ and Microparticle‐Based Delivery Systems

Delivery by Design (DbD): A Standardized Approach to the Development of Efficacious Nanoparticle‐ and Microparticle‐Based Delivery Systems

Microencapsulation of shiitake (Lentinula edodes) essential oil by complex coacervation: formation, rheological property, oxidative stability and odour attenuation effect

Design, fabrication and characterization of pectin-coated gelatin nanoparticles as potential nano-carrier system

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