Encapsulation and surface charge manipulation of organic and inorganic colloidal substrates by multilayered polyelectrolyte films

Mendoza-Dorantes, T.; Pal, U.; Vega-Acosta, J. Roger; Márquez‐Beltrán, César

doi:10.1016/j.colsurfa.2013.05.027

Cited by 7 publications

(7 citation statements)

References 43 publications

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“…MNPs can be modified or assembled with liposomes, cyclic oligosaccharides, peptides or polymers. These increase the stability and biocompatibility of the MNPs in a biological environment and can serve as a support for drug loading 9,10 …”

Section: Introductionmentioning

confidence: 99%

“…These increase the stability and biocompatibility of the MNPs in a biological environment and can serve as a support for drug loading. 9,10 MNPs have been coated with biocompatible and stimuli-responsive polymers using the layer-by-layer (LbL) deposition technique. 10 This technique allows the alternating adsorption of polycations and polyanions, leading to a thin polymeric film, a polyelectrolyte multilayer, on the surface of MNPs.…”

mentioning

confidence: 99%

“…9,10 MNPs have been coated with biocompatible and stimuli-responsive polymers using the layer-by-layer (LbL) deposition technique. 10 This technique allows the alternating adsorption of polycations and polyanions, leading to a thin polymeric film, a polyelectrolyte multilayer, on the surface of MNPs. 11 Drugs can be encapsulated in the multilayers through interaction with the functional groups of the polymers or immobilized within the pores of the multilayer.…”

mentioning

confidence: 99%

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Remotely triggered curcumin release from stimuli‐responsive magneto‐polymericlayer‐by‐layerengineered nanoplatforms

Jardim

Palomec-Garfias

Araújo

et al. 2022

J of Applied Polymer Sci

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Curcumin is a promising natural drug in cancer therapy. However, its therapeutic applicability is limited by its low solubility, short half‐life, and low bioavailability. In this work curcumin is encapsulated in stimuli‐responsive magneto‐polymeric nanoplatforms aiming at improving its bioavailability and efficiency for delivery in biological media. MnFe2O4 magnetic nanoparticles (MNPs) were synthesized via thermal decomposition, coated with sodium citrate and then functionalized with multilayers of chitosan and sodium alginate, by means of the layer‐by‐layer deposition technique. A mesoporous polymeric‐magnetic nanoplatform was produced capable of a controlled and sustained release of curcumin under temperature, pH and alternating magnetic field (magnetic hyperthermia) stimuli. As the temperature and pH of the medium increased, an increase in the rate of curcumin release was observed in a two‐stage process, following the Gallagher‐Corrigan mathematical model. The use of magnetic hyperthermia resulted in a faster diffusion‐based release of curcumin. Increasing the number of polymer layers assembled on top of MNPs hinders the release of the curcumin molecules from innermost regions of the multilayers. These results show that magnetic hyperthermia provides a means for the controlled heat‐induced release of curcumin, which can lead to an enhanced therapeutic action for curcumin.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Remotely triggered curcumin release from stimuli‐responsive magneto‐polymericlayer‐by‐layerengineered nanoplatforms

Jardim

Palomec-Garfias

Araújo

et al. 2022

J of Applied Polymer Sci

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“…Previous studies have reported the use of dye‐doped silica particles for tracking cells, with minimum damage, but these particles showed poor stability and low‐optical response, mainly due to photobleaching that occurs within a few seconds under standard conditions of illumination . In this context, doped rare‐earth oxysulfides (RE 2 O 2 S) are emerging NPs as potential candidates to solve this problem, mainly due to their (1) high photoluminescence, (2) high photostability, (3) blinking absence, (4) extremely narrow emission lines, (5) large stokes shifts, and (6) long lifetimes …”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] Previous studies have reported the use of dye-doped silica particles for tracking cells, with minimum damage, 10 but these particles showed poor stability and low-optical response, mainly due to photobleaching that occurs within a few seconds under standard conditions of illumination. 7,11 In this context, doped rare-earth oxysulfides (RE 2 O 2 S) are emerging NPs as potential candidates to solve this problem, mainly due to their (1) high photoluminescence, (2) high photostability, (3) blinking absence, (4) extremely narrow emission lines, (5) large stokes shifts, and (6) long lifetimes. 12,13 One of the most interesting RE 2 O 2 S is the terbium-doped gadolinium oxysulfide NPs-Gd 2 O 2 S:Tb 31 (GOSNPs), which is a photoluminescent phosphor used as an optical device in solid-state lasers, screens for X-ray detection, optical amplifiers, and color displays.…”

Section: Introductionmentioning

confidence: 99%

Toxicity evaluation of high-fluorescent rare-earth metal nanoparticles for bioimaging applications

Hernández‐Adame

Cortez-Espinosa

Portales-Pérez

et al. 2015

J. Biomed. Mater. Res.

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Research on nanometer-sized luminescent semiconductors and their biological applications in detectors and contrasting agents is an emergent field in nanotechnology. When new nanosize technologies are developed for human health applications, their interaction with biological systems should be studied in depth. Rare-earth elements are used in medical and industrial applications, but their toxic effects are not known. In this work, the biological interaction between terbium-doped gadolinium oxysulfide nanoparticles (GOSNPs) with human peripheral blood mononuclear cells (PBMC), human-derived macrophages (THP-1), and human cervical carcinoma cell (HeLa) were evaluated. The GOSNPs were synthetized using a hydrothermal method to obtain monodisperse nanoparticles with an average size of 91 ± 9 nm. Characterization techniques showed the hexagonal phase of the Gd O S:Tb free of impurities, and a strong green emission at λ = 544 nm produced by Tb was observed. Toxic effects of GOSNPs were evaluated using cell viability, apoptosis, cell-cycle progression, and immunological response techniques. In addition, an Artemia model was used to assess the toxicity in vivo. Results indicated cell apoptosis in both types of cells with less sensitivity for PBMC cells compared to HeLa cells. In addition, no toxic effects were observed in the in vivo model of Artemia. Moreover, GOSNPs significantly reduced the activation and cell-cycle progression of PBMC and HeLa cells, respectively. Interestingly, an increase in proinflammatory cytokines was not observed. Our data suggest that fluorescence applications of GOSNPs for biolabeling are not toxic in primary immune cells and they may have an immunomodulatory effect. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 605-615, 2017.

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Surface-modified iron oxide nanoparticles for adsorption, photodegradation, and selective removal applications

Obaid,

Halbus

2023

Monatsh Chem

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Encapsulation and surface charge manipulation of organic and inorganic colloidal substrates by multilayered polyelectrolyte films

Cited by 7 publications

References 43 publications

Remotely triggered curcumin release from stimuli‐responsive magneto‐polymericlayer‐by‐layerengineered nanoplatforms

Remotely triggered curcumin release from stimuli‐responsive magneto‐polymericlayer‐by‐layerengineered nanoplatforms

Toxicity evaluation of high-fluorescent rare-earth metal nanoparticles for bioimaging applications

Surface-modified iron oxide nanoparticles for adsorption, photodegradation, and selective removal applications

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