Encapsulation and Release of Moxifloxacin Hydrochloride in Chitosan–Dextran Sulphate Microcapsules

Devi, M. Geetha; Dutta, Susmita; Hinai, Ashraf Talib Al; Shaik, Feroz

doi:10.1080/00194506.2013.851874

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…The pH‐dependent drug release of the antibiotic moxifloxacin from polysacccharide based hydrogels has also been observed in other research reports. [ 39,40 ]…”

Section: Resultsmentioning

confidence: 99%

“…The pH-dependent drug release of the antibiotic moxifloxacin from polysacccharide based hydrogels has also been observed in other research reports. [39,40] The release of the antibiotic drug was slow due to the presence of various polymer-drug interactions. The sustained release has maintained the drug content for longer period in the wound site and it can reduce the infection for better wound care.…”

Section: Drug Release Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Design of moxifloxacin encapsulated network hydrogel wound dressings: Evaluation of polymer‐drug, polymer‐blood, and polymer‐bio membrane interactions

Singh

Sharma

Ram

2022

Polymer Engineering & Sci

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It is an exploration of the inherent wound-healing tendency of Azadirachta indica gum (AIG) or neem gum polysaccharides to develop the hydrogel wound dressings with enhanced potential during wound management. Herein this research work, antibiotic moxifloxacin encapsulated AIG network copolymeric hydrogels were developed by functionalizing with carbapol and poly(acrylamide) [poly(AAm)] for better wound healing. The polymer-drug, polymer-blood, and polymer-bio membrane interactions were evaluated in biomedical properties. The copolymeric network structure was confirmed by scanning electron micrographs (SEMs), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), and 13 C solid-state nuclear magnetic resonance (NMR) spectroscopy. The results confirmed sustained release of the moxifloxacin with diffusion by non-Fickian process and Korsmeyer-Peppas kinetic model in the phosphate buffer saline (PBS). These interactions inferred the blood-compatible (hemolytic index 3.41 ± 0.70%) and mucoadhesive nature (polymer-biomembrane detachment force 0.09 ± 0.01 mN) of hydrogel dressing. The per gram of hydrogel dressings absorbed 10.22 ± 0.23 g of simulated wound fluid which is very useful to maintain moist wound environment for better wound healing. All these interactions and properties indicated the suitability of the hydrogel material for wound dressing applications for better wound care.

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“…The pH‐dependent drug release of the antibiotic moxifloxacin from polysacccharide based hydrogels has also been observed in other research reports. [ 39,40 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Drug Release Studiesmentioning

confidence: 99%

Design of moxifloxacin encapsulated network hydrogel wound dressings: Evaluation of polymer‐drug, polymer‐blood, and polymer‐bio membrane interactions

Singh

Sharma

Ram

2022

Polymer Engineering & Sci

View full text Add to dashboard Cite

show abstract

“…Among them, chitosan is a very promising candidate for wound healing due to its strong antibacterial properties against broad spectrum of gram negative and gram positive bacteria as well. Moreover, it is biodegradable, non-toxic, biocompatible, and hemocompatible that are essential to accelerate wound healing process [1][2][3][4][5][6][7]. The N-acetyl glucosamine units present in chitosan and chitin also play a significant role not only in enhancing the reepithelization process but also in repairing wound tissues [8].…”

Section: Introductionmentioning

confidence: 99%

Applications of Chitosan-Sulfathiazole as Antimicrobial Agent

Zvezdova¹

2018

KIJ

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Chitosan, a hydrophilic biopolymer industrially obtained by N-deacetylation of chitin, can be applied as an antimicrobial agent. It highlights the applications of chitosan as an antimicrobial agent against fungi, bacteria, and viruses and as an elicitor of plant defense mechanisms. A series of novel chitosan-sulfathiazole nanocomposite (CSFZ) films were prepared by using solvent casting method for wound healing application. Fourier transform infrared spectroscopy (FTIR) was employed to ascertain the interaction between negatively charged sulfathiazole and positively charged chitosan. Moreover, the antibacterial activity of the films was investigated against gram positive and gram negative microorganisms. It was found that all CSFZ films showed good inhibitory activity against all the tested bacteria as compared to control. The above analysis suggested that the CSFZ films could be used as potential candidates for wound healing application.

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Encapsulation and Release of Moxifloxacin Hydrochloride in Chitosan–Dextran Sulphate Microcapsules

Cited by 2 publications

References 28 publications

Design of moxifloxacin encapsulated network hydrogel wound dressings: Evaluation of polymer‐drug, polymer‐blood, and polymer‐bio membrane interactions

Design of moxifloxacin encapsulated network hydrogel wound dressings: Evaluation of polymer‐drug, polymer‐blood, and polymer‐bio membrane interactions

Applications of Chitosan-Sulfathiazole as Antimicrobial Agent

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