Encapsulation and release behavior of curcumin based on nanoemulsions-filled alginate hydrogel beads

Xu, Wei; Huang, Lu; Jin, Weiping; Ge, Peipei; Shah, Bakht Ramin; Zhu, Dandan; Jing, Junxiang

doi:10.1016/j.ijbiomac.2019.04.200

Cited by 65 publications

(19 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This observation was very similar to our previous study on the oxidized dextran crosslinked chitosan/NaCas complex nanoparticles [17]. This kinetic release profile was significantly slower than most of other colloidal systems, including solid lipid nanoparticles [3,33], polysaccharide/protein complex nanoparticles [34,35], and nano-in-hydrogel beads [36,37]. It will be interesting to investigate how these complex nanoparticles can be absorbed through small intestinal mucosal and carry curcumin into the circulation.…”

Section: Resultssupporting

confidence: 89%

Oxidized Dextran as a Macromolecular Crosslinker Stabilizes the Zein/Caseinate Nanocomplex for the Potential Oral Delivery of Curcumin

Rodriguez

Luo

2019

Molecules

View full text Add to dashboard Cite

In this study, we prepared complex nanoparticles from a combination of two proteins and one polysaccharide for the encapsulation and delivery of lipophilic bioactive compounds. Two proteins, zein and sodium caseinate (NaCas), provided a hydrophobic core for the encapsulation of a lipophilic compound (curcumin), while a polysaccharide dialdehyde, oxidized dextran, served as the coating material and macromolecular crosslinker to create covalent linkage with two proteins for stabilization purposes. The heating time and crosslinker concentration were optimized to achieve the desirable colloidal stability in simulated gastric and intestinal fluids. Our results suggested that heating time played a more important role than the concentration of oxidized dextran. The optimized complex nanoparticles had a particle size of around 150 nm with a PDI < 0.1 and negative surface charge. Morphological observation by transmission electron microscopy revealed a spherical shape and uniform size distribution. Fourier transform infrared and fluorescence spectroscopies evidenced the formation of Schiff base complex, confirming the validity of covalent crosslinking. Furthermore, the complex nanoparticles demonstrated superior encapsulation properties for curcumin, showing an efficiency of >90% at 10% loading. A rather slow kinetic release profile of curcumin from complex nanoparticles was observed under simulated gastrointestinal conditions. The complex nanoparticles prepared from zein, NaCas, and oxidized dextran hold promising potential for the oral delivery of lipophilic bioactive compounds.

show abstract

Section: Resultssupporting

confidence: 89%

Oxidized Dextran as a Macromolecular Crosslinker Stabilizes the Zein/Caseinate Nanocomplex for the Potential Oral Delivery of Curcumin

Rodriguez

Luo

2019

Molecules

View full text Add to dashboard Cite

show abstract

“…Free Cur (the supernatant solution) solution was obtained after centrifugation at 1888 g for 30 min at 4°C, and the content of Cur was estimated from a standard X‐Y plot of Cur (dissolved in ethanol) versus concentration. Encapsulation efficiency (EE) and loading capacity (LC) were defined as the drug content encapsulated into Ly NPs and calculated as follows (Xu et al, ):

EE false(% false) = \frac{Total Cur - Free Cur}{Total Cur} \times 100

LC false(μ g false/ g false) = \frac{Total Cur - Free Cur}{Weight of Ly NPs} \times 100

…”

Section: Methodsmentioning

confidence: 99%

Curcumin encapsulation and protection based on lysozyme nanoparticles

Cui

Zhou

Huang

et al. 2019

Food Science & Nutrition

Self Cite

View full text Add to dashboard Cite

Curcumin possesses antioxidant, anti‐inflammatory, and other properties. However, this compound exhibits low bioavailability because of its poor solubility and stability. In this paper, lysozyme nanoparticles were fabricated through solvent evaporation, and then, the solubilization and protection capability of curcumin were investigated. Lysozyme nanoparticles were characterized by dynamic light scattering technique, atomic force microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy. The load capacity and stability in thermal environment were further explored. Results showed that the lysozyme nanoparticle displayed a spherical structure (127.9 ± 2.12 nm) with favorable distribution. The solubility of curcumin can increase to 22 μg/mL. After encapsulation by lysozyme nanoparticles, the retentive curcumin can reach up to 67.9% and 30.25% at 25°C and 50°C, respectively, significantly higher than that of free curcumin. Meanwhile, experiments on DPPH free radicals indicated the curcumin loaded by lysozyme nanoparticle possessed higher free radical scavenging activity than that of free curcumin with same treatments. The results confirmed that lysozyme nanoparticles exhibit potential applications in solubilizing and protecting the environment‐sensitive hydrophobic functional components.

show abstract

“…Thus, incorporation of the curcumin into nanoemulsion‐based hydrogels can decrease its release rate considerably. Previous studies have concluded that the release of lipophilic bioactive compound from alginate hydrogels were controlled by both swelling of the hydrogels and diffusion of active compounds (Xu et al, 2019), however, due to the obtained first‐order kinetics in current research it can be concluded that the release of curcumin from synthesized hydrogels is diffusion controlled due to non‐degradability of hydrogels during the release process.…”

Section: Resultsmentioning

confidence: 58%

Preparation of Nano‐Emulsion‐Based Hydrogels Conjugated Curcumin as Model Functional Lipid Bioactive Compound

Heidarifard

Taghavi

Anarjan

2021

J Americ Oil Chem Soc

View full text Add to dashboard Cite

The preparation of nanoemulsion‐based alginate hydrogels, containing curcumin was the aim of current study. The nanoemulsions of coconut oil were prepared using solvent‐displacement technique and then the obtained nanoemulsions were converted to hydrogels using the ion‐gelling process. The effects of formulation parameters, namely, sodium alginate concentration (1–2 g L−1), the weight ratio of calcium chloride to sodium alginate (2–4), and curcumin to sodium alginate (1–3), were also evaluated on swelling percentage, gel fraction, curcumin load, curcumin release, and antibacterial inhibitory zone of hydrogels. All studied characteristics were successfully correlated to the selected independent variables by second‐order polynomial equations as models, with relatively high coefficients of determinations (R2 > 86). According to multiple numerical optimization analysis, the most desired hydrogels can be obtained using 1.9 g L−1 sodium alginate, curcumin/sodium alginate of 2.5 g g−1, and calcium chloride/sodium alginate of 2.2 g g−1, with the maximum swelling ratio (216%), gel fraction (29.9%), curcumin load (59.12%), antibacterial activity (clear‐zone diameter of 5.27 cm), and the least curcumin release after 12 hours (87.75%). It was also resulted that the curcumin release from prepared optimum hydrogel obeys the first order kinetics. No significant differences between the measured and predicted data confirmed the suitability of suggested models.

show abstract

Encapsulation and release behavior of curcumin based on nanoemulsions-filled alginate hydrogel beads

Cited by 65 publications

References 37 publications

Oxidized Dextran as a Macromolecular Crosslinker Stabilizes the Zein/Caseinate Nanocomplex for the Potential Oral Delivery of Curcumin

Oxidized Dextran as a Macromolecular Crosslinker Stabilizes the Zein/Caseinate Nanocomplex for the Potential Oral Delivery of Curcumin

Curcumin encapsulation and protection based on lysozyme nanoparticles

Preparation of Nano‐Emulsion‐Based Hydrogels Conjugated Curcumin as Model Functional Lipid Bioactive Compound

Contact Info

Product

Resources

About