Encapsulated papillary carcinoma of the breast: A clinicopathological study of 49 cases

Encapsulated papillary carcinoma with and without frank invasion: Comparison of clinicopathologic features and role of axillary staging

“…EPCs primarily affect postmenopausal women, are low to intermediate grade, ER‐positive, and range from 1.0 to 4.0 cm in size 2,7,8,10,11,23 . The associated invasive tumors are typically small (pT1), low to intermediate grade, ER‐positive, HER2‐negative and are most frequently invasive ductal carcinoma‐NST 2,7,8,10,11,23 . Invasive disease was present in 60% of cases in our study, comparable to recent studies where the frequency of frank invasion ranged from 38%‐53% 2,8,11,12 .…”

“…EPCs without an invasive component are generally indolent tumors 6,14,15 . Metastases are reportedly more common in EPCs with an invasive component as individual studies have reported lymph node metastatic rates of approximately 10% in these patients 10,23 . In the present study, no lymph node metastases were discovered in the 17 patients who underwent axillary staging.…”

“…The clinicopathologic features in our patient cohort were in keeping with EPCs reported in recent literature. EPCs primarily affect postmenopausal women, are low to intermediate grade, ER‐positive, and range from 1.0 to 4.0 cm in size 2,7,8,10,11,23 . The associated invasive tumors are typically small (pT1), low to intermediate grade, ER‐positive, HER2‐negative and are most frequently invasive ductal carcinoma‐NST 2,7,8,10,11,23 .…”

<p>Magnetic Resonance Imaging (MRI) Phenotypes May Provide Additional Information for Risk Stratification for Encapsulated Papillary Carcinoma of the Breast</p>

“…Several studies have demonstrated that the classification has clear prognostic significance, suggesting that the prognosis of EPC is excellent compared with that of EPC with invasion. [5][6][7] Moreover, the clinical management of these two types is also different. Local excision with negative surgical margins seems to be sufficient for pure EPC; however, EPC with invasion are staged and managed according to characteristics of the invasive component.…”

The significance of accurate diagnosis of encapsulated papillary carcinoma of the breast by core needle biopsy

“…The spectrum of diagnostic challenges associated with papillary lesions of the breast includes differentiation between intraductal papilloma with florid hyperplasia and atypical papilloma, and distinction between atypical papilloma versus low grade ductal carcinoma in situ arising within an intraductal papilloma versus papillary ductal carcinoma in situ. Another diagnostic issue is the recognition of different variants of papillary carcinoma 4,5 …”