Enantioseparation of fourteen amino alcohols by nonaqueous capillary electrophoresis using lactobionic acid/<scp>d</scp>-(+)-xylose–boric acid complexes as chiral selectors

An, Ning; Wang, Lijuan; Zhao, Jingjing; Lv, Lili; Wang, Ning; Guo, Hongwei

doi:10.1039/c5ay02686e

Cited by 20 publications

(9 citation statements)

References 29 publications

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“…In nonaqueous CE, clarithromycin as a chiral selector was used for the enantioseparation of clenbuterol [143]. Two new chiral selectors, lactobionic acid-boric acid complex and D-(+)-xylose-boric acid complex, were synthesized in situ in nonaqueous background electrolytes containing methanol and triethylamine and were found to be applicable for the enantioseparation of several β 2 -agonists [144].…”

Section: Stereoselective Ce Methods For Determination Of β 2 -Agonistsmentioning

confidence: 99%

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

2020

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Abstractβ2-Agonists (β2-adrenergic agonists, bronchodilatants, and sympathomimetic drugs) are a group of drugs that are mainly used in asthma and obstructive pulmonary diseases. In practice, the substances used to contain one or more stereogenic centers in their structure and their enantiomers exhibit different pharmacological properties. In terms of bronchodilatory activity, (R)-enantiomers showed higher activity. The investigation of stereoselectivity in action and disposition of chiral drugs together with the preparation of pure enantiomer drugs calls for efficient stereoselective analytical methods. The overview focuses on the stereoselectivity in pharmacodynamics and pharmacokinetics of β2-agonists and summarizes the stereoselective analytical methods for the enantioseparation of racemic beta-agonists (HPLC, LC-MS, GC, TLC, CE). Some methods of the stereoselective synthesis for β2-agonists preparation are also presented.

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Section: Stereoselective Ce Methods For Determination Of β 2 -Agonistsmentioning

confidence: 99%

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

2020

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“…In addition to the use of aqueous solvents for chiral separation in CZE, non-aqueous capillary electrophoresis (NACE) has also been successfully applied to chiral material analysis. For example, An et al [ 101 ] used lactobionic acid/ d -(+)-xylose–boric acid complexes as CSs in chiral NACE. A buffer solution of methanol and triethylamine was used as the background electrolyte and achieved good resolution of fourteen amino alcohol chiral compounds.…”

Section: Chromatographic Separationmentioning

confidence: 99%

Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects

et al. 2021

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With the rapid development of global industry and increasingly frequent product circulation, the separation and detection of chiral drugs/pesticides are becoming increasingly important. The chiral nature of substances can result in harm to the human body, and the selective endocrine-disrupting effect of drug enantiomers is caused by differential enantiospecific binding to receptors. This review is devoted to the specific recognition and resolution of chiral molecules by chromatography and membrane-based enantioseparation techniques. Chromatographic enantiomer separations with chiral stationary phase (CSP)-based columns and membrane-based enantiomer filtration are detailed. In addition, the unique properties of these chiral resolution methods have been summarized for practical applications in the chemistry, environment, biology, medicine, and food industries. We further discussed the recognition mechanism in analytical enantioseparations and analyzed recent developments and future prospects of chromatographic and membrane-based enantioseparations.

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“…CE in all of its variants is well-established in analysis of small drug analysis. Recent work focused on sensitivity improvement by including sample-stacking approaches , and probing drug chirality. , …”

Section: Applicationsmentioning

confidence: 99%

“…Recent work focused on sensitivity improvement by including sample-stacking approaches 183,184 and probing drug chirality. 185,186 A fast CZE method for the simultaneous analysis of glibenclamide and its impurities (I A and I B ) in pharmaceutical dosage forms was fully developed within a quality by design framework. 187 Critical quality attributes were represented by I A peak efficiency, critical resolution between glibenclamide and I B , and analysis time.…”

Section: T H Imentioning

confidence: 99%

Capillary Electrophoresis: Trends and Recent Advances

et al. 2018

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Enantioseparation of fourteen amino alcohols by nonaqueous capillary electrophoresis using lactobionic acid/d-(+)-xylose–boric acid complexes as chiral selectors

Abstract: An interesting study on chiral nonaqueous capillary electrophoresis (NACE) was developed in this paper.

Cited by 20 publications

References 29 publications

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

Chirality of β2-agonists. An overview of pharmacological activity, stereoselective analysis, and synthesis

Chiral Recognition for Chromatography and Membrane-Based Separations: Recent Developments and Future Prospects

Capillary Electrophoresis: Trends and Recent Advances

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