Enantioseparation by simultaneous biphasic recognition using mobile phase additive and chiral stationary phase in capillary electrochromatography

Tang, Weiyang; Row, Kyung Ho

doi:10.1016/j.chroma.2022.462856

Cited by 10 publications

(2 citation statements)

References 32 publications

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“…Usually, one-step chiral in-situ polymerization is employed to prepare chiral MCCs. The commonly used chiral stationary phases in MCCs are various derivatives of β-cyclodextrin [25][26][27][28], and others include cellulose [29][30][31], pepsin [32,33], polymyxin-B [34] and (S)-(-)−1-(2-naphthyl)ethylamine [35]. It is worth mentioning that metal-organic frameworks [29,32], COFs [30], and gold nanoparticles [36] can improve the enantioseparation ability of chiral MCCs.…”

Section: Introductionmentioning

confidence: 99%

Chiral covalent organic framework incorporated organic polymer monolithic capillary column for enantioseparations

Song

Chen

et al. 2023

J of Separation Science

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A chiral covalent organic framework was synthesized, characterized, and incorporated into organic polymer monolithic capillary columns to provide chiral stationary phases for enantioseparations. The prepared monolithic capillary columns were characterized by scanning electron microscopy and elemental analysis. To obtain better enantioseparations, the columns’ preparation conditions, and enantioseparation conditions were optimized. Baseline resolutions of several chiral compounds were obtained with good reproducibility and stability. Furthermore, the mechanism of chiral recognition was investigated using molecular docking with AutoDock. Docking results showed that the enantioselectivity factor rather than resolution is correlated with the binding free energy difference between enantiomers with the chiral covalent organic framework. And abundant acetoxy and nitrile groups as well as benzene rings in the chiral covalent organic framework are responsible for the enantioseparation ability of the chiral monolithic capillary columns.

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Section: Introductionmentioning

confidence: 99%

Chiral covalent organic framework incorporated organic polymer monolithic capillary column for enantioseparations

Song

Chen

et al. 2023

J of Separation Science

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“…Capillary electrochromatography (CEC) is a hybrid micro-column separation technique that combines the high separation efficiency of capillary electrophoresis with the high selectivity of liquid chromatography [8][9][10]. It is worth emphasising that the small injection volume (i.e., nanolitre amounts) used in CEC is attractive for precious biological samples [11].…”

Section: Introductionmentioning

confidence: 99%

Preparation of a zeolite imidazole skeleton–silica hybrid monolithic column for amino acid analysis via capillary electrochromatography

et al. 2022

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We developed a novel, convenient and low-cost one-pot strategy for preparing a zeolitic imidazolate framework-8 (ZIF-8)-silica hybrid monolithic column by adding ZIF-8 directly to a polymer solution of the silica matrix. The simulated stationary phase and monolithic column prepared under optimal conditions were characterized using X-ray diffraction, scanning electron microscopy, Fourier-transform infrared spectroscopy, thermogravimetric analysis nitrogen physisorption and zeta potential. The results obtained confirmed the successful introduction of ZIF-8 into the silica monolithic column, and the prepared monolithic column exhibited good permeability and physicochemical stability. A capillary electrochromatography method was developed based on a ZIF-8-silica hybrid monolithic column through which 15 mixed amino acids, 4 neutral compounds, 4 nipagin esters and 2 chlorinated fungicides were separated in 14, 5, 7 and 6 min, respectively, under optimal conditions. The relative standard deviations retention times and column efficiencies in run-to-run, day-to-day and column-to-column varied in the ranges of 1.90%-2.21%, 2.13%-2.51% and 3.08%-6.65%, respectively, which demonstrated that ZIF-8-silica hybrid monolithic column exhibited satisfactory reproducibility and stability. The incorporation of ZIF-8 into a silica monolithic column is a promising method for preparing novel monolithic columns composed of a metal-organic framework.

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Lipase-based MIL-100(Fe) biocomposites as chiral stationary phase for high-efficiency capillary electrochromatographic enantioseparation

Choi

Baeck

et al. 2023

Microchim Acta

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Enantioseparation by simultaneous biphasic recognition using mobile phase additive and chiral stationary phase in capillary electrochromatography

Cited by 10 publications

References 32 publications

Chiral covalent organic framework incorporated organic polymer monolithic capillary column for enantioseparations

Chiral covalent organic framework incorporated organic polymer monolithic capillary column for enantioseparations

Preparation of a zeolite imidazole skeleton–silica hybrid monolithic column for amino acid analysis via capillary electrochromatography

Lipase-based MIL-100(Fe) biocomposites as chiral stationary phase for high-efficiency capillary electrochromatographic enantioseparation

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